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Analysis of the inflammatory response and microRNAs expression of smoker patients after orange juice and orange juice with anthocyanins intake

Grant number: 16/20646-0
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): October 01, 2017
Effective date (End): September 30, 2020
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Marcos Ferreira Minicucci
Grantee:Mariana de Souza Dorna
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


Smoking habit, specially cigarette is one of the main causes of inflammatory and lung diseases. Approximately 1 billion people worldwide consume tobacco derived products, representing an important public health problem. On the other hand, consumption of food sources of bioactive compounds (BAC) as flavonoids, are associated with lower risk of chronic diseases. The orange juice has great consumption in the world, andinBrazil it is the main source of BAC for the population. Several studies have reported that BAC have antioxidant and anti-inflammatory activity. Previous studies have shown that consumption of compounds present in orange juice can reduce inflammation. However, the molecular mechanisms responsible for this beneficial effect have not been clarified. This work aims to study the inflammatory response and changes in protein expression and microRNA (miRNA) by the consumption of two types of orange juice in smokers individuals. Patients consume orange juice, orange juice with anthocyanin or isocaloric control (water with maltodextrin and vitamin C), followed by blood collections at 0, 1, 3 and 5 hours. The inflammatory response and the expression of miRNAs will be evaluated in the blood. Accordingly, from the present study, changes in inflammatory and epigenetic markers resulting from the intake of two types of orange juice in smokers patients can be identified, as well some molecular mechanisms involved in this signaling. Keywords:citrus, inflammation, cigarette smoke, microRNA (AU)

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