Influence of the absence of maternal melatonin during pregnancy and lactation on neurogenesis and on somatic and sensorimotor development of the offspring.

• Grant number: 14/22313-3
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: March 01, 2016
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Principal Investigator: José Cipolla Neto
• Grantee: Lívia Clemente Motta Teixeira
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 14/50457-0 - Melatonin and the control of energy metabolism: basic, clinical and epidemiological research, AP.TEM
• Associated scholarship(s): 16/18941-4 - Effects of maternal melatonin deprivation during pregnancy and lactation on the offspring neuroimmune system, BE.EP.DR

Abstract

Shift  work is a widespread practice in our society, which is detrimental to the health of workers. These impairments may be associated with changes in melatonin synthesis, which plays a role in the regulation of energy metabolism and neurogenesis functions. It is known that melatonin is a hormone that has been shown to be essential in intrauterine programming and immediate post-natal as well as being of fundamental importance in the expression of neural plastic processes. Thus it is possible that neurogenic changes occurs in response to the absence of maternal melatonin during pregnancy and / or lactation leading, knowingly, to metabolic disorders in the offspring and the possible neurogenic changes, whether induced directly, are mediated by metabolic disorders.In this proposal we aim to to evaluate whether hippocampal and hypothalamic neurogenesis is disturbed by the absence of melatonin during pregnancy and lactation and / or the metabolic dysfunction cause.In adition, evaluate possible changes the somatic and neurological development of the offspring.

Scientific publications

(9)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

KUMAR, AMRITA JHA; TAKADA, SILVIA HONDA; MOTTA-TEIXEIR, LIVIA CLEMENTE; LEE, VITOR YONAMINE; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES. Sex differences in somatic and sensory motor development after neonatal anoxia in Wistar rats. Behavioural Brain Research, v. 333, p. 242-250, AUG 30 2017. (14/22313-3, 15/18415-8)

KUMAR, AMRITA JHA; MARTINS, DANIEL OLIVEIRA; ARRUDA, BRUNA PETRUCELLI; LEE, VITOR YONAMINE; CHACUR, MARUCIA; NOGUEIRA, MARIA INES. Impairment of nociceptive responses after neonatal anoxia correlates with somatosensory thalamic damage: A study in rats. Behavioural Brain Research, v. 390, JUL 15 2020. (15/18415-8, 14/22313-3)

HELOU, AMMIR YACOUB; MARTINS, DANIEL OLIVEIRA; ARRUDA, BRUNA PETRUCELLI; DE SOUZA, MATHEUS CERUSSI; CRUZ-OCHOA, NATALIA ANDREA; NOGUEIRA, MARIA INES; CHACUR, MARUCIA. Neonatal anoxia increases nociceptive response in rats: Sex differences and lumbar spinal cord and insula alterations. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 81, n. 8, AUG 2021. (15/18415-8, 14/22313-3, 17/05218-5, 15/24256-0)

KUMAR, AMRITA JHA; MOTTA-TEIXEIRA, LIVIA CLEMENTE; TAKADA, SILVIA HONDA; YONAMINE-LEE, VITOR; MACHADO-NILS, ALINE VILAR; XAVIER, GILBERTO FERNANDO; NOGUEIRA, MARIA INES. Behavioral, cognitive and histological changes following neonatal anoxia: Male and female rats' differences at adolescent age. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, v. 73, p. 50-58, APR 2019. (14/22313-3, 16/18941-4, 15/18415-8)

MOTTA-TEIXEIRA, LIVIA CLEMENTE; MACHADO-NILS, ALINE VILAR; BATTAGELLO, DANIELLA SABINO; DINIZ, GIOVANNE BARONI; ANDRADE-SILVA, JESSICA; SILVA JR, SINESIO; MATOS, RAPHAEL AFONSO; DO AMARAL, FERNANDA GASPAR; XAVIER, GILBERTO FERNANDO; BITTENCOURT, JACKSON CIONI; et al. The absence of maternal pineal melatonin rhythm during pregnancy and lactation impairs offspring physical growth, neurodevelopment, and behavior. Hormones and Behavior, v. 105, p. 146-156, SEP 2018. (12/04554-8, 16/02224-1, 16/02748-0, 10/52068-0, 14/22313-3, 14/50457-0, 16/18941-4)

DINIZ, GIOVANNE B.; BATTAGELLO, DANIELLA S.; CHERUBINI, PEDRO M.; REYES-MENDOZA, JULIO D.; LUNA-ILLADES, CESAR; KLEIN, MARIANNE O.; MOTTA-TEIXEIRA, LIVIA C.; SITA, LUCIANE V.; MIRANDA-ANAYA, MANUEL; MORALES, TERESA; et al. Melanin-concentrating hormone peptidergic system: Comparative morphology between muroid species. JOURNAL OF COMPARATIVE NEUROLOGY, v. 527, n. 18, p. 2973-3001, DEC 15 2019. (16/02224-1, 16/02748-0, 14/22313-3, 17/17998-5, 16/18941-4, 17/16293-8)

COSTA, HELDER C.; DA-SILVA, JOELCIMAR M.; DINIZ, GIOVANNE B.; MOTTA-TEIXEIRA, LIVIA C.; DA-SILVA, RENATA J.; BATTAGELLO, DANIELLA S.; SITA, V, LUCIANE; MACHADO, CARLA DE-MORAES; HORTA-JUNIOR, JOSE A. C.; BITTENCOURT, JACKSON C.. Characterisation and origins of melanin-concentrating hormone immunoreactive fibres of the posterior lobe of the pituitary and median eminence during lactation in the Long-Evans rat. Journal of Neuroendocrinology, v. 31, n. 9, SI, SEP 2019. (16/02224-1, 16/02748-0, 13/08618-3, 14/22313-3, 08/02771-6, 16/18941-4, 09/06769-9)

DINIZ, GIOVANNE B.; BATTAGELLO, DANIELLA S.; KLEIN, MARIANNE O.; BONO, BIANCA S. M.; FERREIRA, JOZELIA G. P.; MOTTA-TEIXEIRA, LIVIA C.; DUARTE, JESSICA C. G.; PRESSE, FRANCOISE; NAHON, JEAN-LOUIS; ADAMANTIDIS, ANTOINE; et al. Ciliary melanin-concentrating hormone receptor 1 (MCHR1) is widely distributed in the murine CNS in a sex-independent manner. Journal of Neuroscience Research, v. 98, n. 10, JUN 2020. (15/05990-4, 16/02748-0, 17/16293-8, 17/17998-5, 16/18941-4, 16/19845-9, 16/02224-1, 14/22313-3)

KUMAR, AMRITA JHA; HELOU, AMMIR YACOUB; PETRUCELLI, BRUNA ARRUDA; XAVIER, GILBERTO FERNANDO; MARTINS, DANIEL OLIVEIRA; CHACUR, MARUCIA; NOGUEIRA, MARIA INES. Sensorimotor development of male and female rats subjected to neonatal anoxia. DEVELOPMENTAL PSYCHOBIOLOGY, v. 64, n. 7, p. 10-pg., 2022-11-01. (14/22313-3, 15/18415-8)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

TEIXEIRA, Lívia Clemente Motta. Effects of the absence of maternal pineal melatonin during pregnancy and lactation offspring neurogenesis, physical growth, neurodevelopment, and behavior.. 2019. Doctoral Thesis - Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB/SDI) São Paulo.