| Grant number: | 15/02866-0 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | March 01, 2016 |
| End date: | July 07, 2019 |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Giuseppe Palmisano |
| Grantee: | Rebeca Kawahara Sakuma |
| Host Institution: | Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 14/06863-3 - Post-translational modifications in cancer and parasite infection diagnosis: methodological approaches and biological implications, AP.JP |
| Associated scholarship(s): | 17/03010-8 - Site-specific characterization of N- and O-linked glycosylation in prostate cancer tissues as molecular signature for disease progression, BE.EP.PD |
Abstract Prostate cancer (PCa) is the second most frequently diagnosed cancer in Brazil. Serum prostate specific antigen (PSA) is currently used for early detection of prostate cancer, however it lacks in specificity especially in Benign Prostatic Hyperplasia (BPH). Besides, it has limited accuracy to determine poor prognosis or drug resistance conditions. A growing body of evidence supports crucial roles for glycoproteins at various pathophysiological steps of tumor progression, including proliferation, invasion, metastasis, angiogenesis and drug resistance. It has been demonstrated that not only the levels of glycoproteins are altered in malignant conditions but also the glycosylation patterns. Therefore, the quantification of different glycoforms can improve the biomarker potential of these glycoproteins. This project aims to identify a panel of intact glycopeptides differentially expressed in urines from control and prostate cancer patients. For that, mass spectrometry-based proteomics approaches will be used for both discovery as well as verification of the candidate glycopeptides biomarkers. With this project, we want to improve the understanding of glycosylation in cancer and present a novel strategy for discovery and verification of candidate glycopeptide biomarkers more specific in prostate cancer. | |
| News published in Agência FAPESP Newsletter about the scholarship: | |
| More itemsLess items | |
| TITULO | |
| Articles published in other media outlets ( ): | |
| More itemsLess items | |
| VEICULO: TITULO (DATA) | |
| VEICULO: TITULO (DATA) | |