The prevalence of overweight in adolescents is increasing in parallel with changes in lifestyle. The understanding of nutritional status over time and associated factors, such as diet, is essential to develop effective actions in health. Additionally, there are gaps in the understanding of gene-diet relationships that may be relevant to understand the mechanisms regulating body weight, identifying individuals who are more susceptible to a particular intervention or exposure. The aim of the project is to investigate the diet, overweight and the effects of single nucleotide polymorphisms (SNPs) associated with adiposity in adolescents of São Paulo city. Data are from a cross-sectional population-based survey among a representative sample of adolescents living in Sao Paulo, Brazil (ISA-Capital Survey) in 2003, 2008, and 2015. Socioeconomic, anthropometric and lifestyle data were collected on households or by telephone. Food consumption data were obtained by two 24 hours dietary recalls. SNPs in/near BMI-related genes and associated with diet interactions will be evaluated in adolescents. Trends across the years will be evaluated in panel data, considering the complexity of the sample. Logistic regression models will be used to investigate the association between diet and SNPs with nutritional status. Structural equation models will be used to evaluate the relationship between SNPs with diet predicting overweight.
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