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Carbohydrate Quality Index: overview of the last decade, relation with micronutrient status and insulin resistance

Grant number: 16/18742-1
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2017
Effective date (End): December 31, 2019
Field of knowledge:Health Sciences - Nutrition - Nutritional Analysis of Population
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Regina Mara Fisberg
Grantee:Mariane de Mello Fontanelli
Host Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated scholarship(s):18/08268-6 - Carbohydrate quality index and cardiometabolic risk factors in adolescents, adults and older adults living in São Paulo and in the United States of America, BE.EP.DR


Diets with high glycemic index, rich in liquid and refined carbohydrates, but low in fiber and whole grains are related to the development of insulin resistance and the inadequacy of micronutrients recommendations. Moreover, vitamins B6, C and E and the minerals zinc and magnesium play a role in the etiology of insulin resistance by acting on key metabolic pathways for normal insulin response. The aim of this study is to investigate the relationship between the carbohydrate quality index and micronutrient status and insulin resistance in adolescents, adults and elderly adults living in São Paulo. Data will be used from the Health Survey of São Paulo conducted in 2003, 2008 and 2015. It is a cross-sectional population-based study with a representative sample of adolescents, adults elderly adults in the municipality permanent homes. Demographic, socioeconomic, anthropometric and lifestyle data were collected on home visits and by telephone survey. Food consumption was investigated by two 24 hours dietary recalls. The quality of the carbohydrate will be evaluated using an index that takes into account four aspects of the nutrient: total fiber; glycemic index; ratio whole grains / (whole grains + refined grains or products); ratio solid carbohydrate / (solid carbohydrate + liquid carbohydrate). Single nucleotide polymorphisms related to insulin resistance will be evaluated and considered as adjustments in the analysis. The relationship between carbohydrate quality index, the biochemical status of vitamins B6, C and E and minerals zinc and magnesium and insulin resistance will be investigated by structural analysis equation. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
FONTANELLI, MARIANE DE M.; SALES, CRISTIANE H.; DE CASTRO, MICHELLE A.; FISBERG, REGINA M.. Healthful grain foods consumption by Sao Paulo residents: a 12-year analysis and future trends. PUBLIC HEALTH NUTRITION, v. 24, n. 10, p. 2987-2997, . (16/18742-1, 09/15831-0, 12/22113-9)
FONTANELLI, MARIANE DE MELLO; MICHA, RENATA; SALES, CRISTIANE HERMES; LIU, JUNXIU; MOZAFFARIAN, DARIUSH; FISBERG, REGINA MARA. Application of the <= 10:1 carbohydrate to fiber ratio to identify healthy grain foods and its association with cardiometabolic risk factors. EUROPEAN JOURNAL OF NUTRITION, v. 59, n. 7, p. 3269-3279, . (18/08268-6, 16/18742-1, 12/22113-9)
FONTANELLI, MARIANE DE MELLO; ARROYO, ANGELA MARTINEZ; SALES, CRISTIANE HERMES; SEAL, CHRIS J.; FISBERG, REGINA MARA. Opportunities for diet quality improvement: the potential role of staple grain foods. PUBLIC HEALTH NUTRITION, v. 24, n. 18, p. 6145-6156, . (16/18742-1, 12/22113-9, 17/05125-7)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
FONTANELLI, Mariane de Mello. The ≤10:1 carbohydrate to fiber ratio to identify healthful grain foods: panorama of consumption, association with cardiometabolic risk factors and impact on nutrient intake. 2020. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Saúde Pública (FSP/CIR) São Paulo.

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