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Nitrogen and nucleic acids metabolism in dairy cows fed with lipid source

Grant number: 16/02855-1
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): July 01, 2016
Effective date (End): August 31, 2018
Field of knowledge:Agronomical Sciences - Animal Husbandry - Animal Production
Principal researcher:Francisco Palma Rennó
Grantee:Tiago Antonio Del Valle
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Energy and protein nutrition of ruminants present as major cost of feed for ruminants. Special interest has been given to the study of rumen nitrogen metabolism in dairy cows, given the cost of protein sources in diets. The evaluation technical of ruminal metabolism and especially estimation of microbial protein synthesis has been questioned, mainly by difficulties in estimating the post ruminal flow of amino acids. The literature is scarce information about the ruminal metabolism of nitrogen and especially the post absorptive metabolism of nucleic acids, when lipid sources are added to dairy cows diets. Some studies suggest reducing the degradability of protein diet and microbial synthesis with increased synthesis efficiency, as fat sources are used in the diet. Moreover, with the change in the metabolism as a result of increased energy density of the diet and serum cholesterol concentration, there may be change in muscle protein turnover and cellular ATP synthesis, leading to changes in the metabolism of nucleic acids, changing the composition of compounds excreted in urine and endogenous contribution of the purine derivatives excreted. This study aims to evaluate the ruminal and post-ruminal events associated with the addition of a lipid source in the diet, as well as increasing the concentration of degradable protein in the rumen in these diets.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DEL VALLE, T. A.; ZILIO, E. M. C.; GHIZZI, L. G.; MARQUES, J. A.; DIAS, M. S. S.; SOUZA, J. M.; SILVA, T. B. P.; SCOGNAMIGLIO, N. T.; NUNES, A. T.; GHELLER, L. S.; SILVA, G. G.; RENNO, F. P. Effect of calcium salts of fatty acids and level of rumen degradable protein on nitrogen metabolism and performance of dairy cows fed corn silage-based diets. LIVESTOCK SCIENCE, v. 254, DEC 2021. Web of Science Citations: 0.
DEL VALLE, T. A.; GHIZZI, L. G.; ZILIO, E. M. C.; MARQUES, J. A.; DIAS, M. S. S.; SILVA, T. B. P.; GHELLER, L. S.; SILVA, G. G.; SCONAMIGLIO, N. T.; NUNES, A. T.; RENNO, L. N.; COSTA, V. E.; RENNO, F. P. Evaluation of N-15 and purine bases as microbial markers to estimate ruminal bacterial nitrogen outflow in dairy cows. ANIMAL FEED SCIENCE AND TECHNOLOGY, v. 258, DEC 2019. Web of Science Citations: 0.
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
. Nitrogen, nucleic acids and fatty acids metabolism in dairy cows fed fat diet. 2018. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina Veterinária e Zootecnia (FMVZ/SBD) Pirassununga.

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