Stability and release study of encapsulated bromelain in chitosan nanoparticles

• Grant number: 16/02282-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2016
• End date: October 29, 2018
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Eloah Favero Gérios
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 17/05333-9 - Bromelain encapsulation: characterization and stability, BE.EP.IC

Abstract

Nanoparticles are carrier systems of organic compounds, such as bromelain, promising for facilitating the bioavailability of these compounds in pharmaceuticals. Bromelain is a protein found in pineapple steam and fruit (from Bromeliaceae family), which has proteolytic, healing, anticancer, anti-inflammatory, among others properties, being widely used in drug, food and textile industry. The nanoencapsulation of bromelain in order to improve its stability and release in pharmaceuticals is still poorly understood. This project aims to study the stability and release of bromelain by nanoparticles made of chitosan. As well as compared its stability to free bromelain and empty chitosan nanoparticles stabilities.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ATAIDE, JANAINA ARTEM; GERALDES, DANILO COSTA; GERIOS, ELOAH FAVERO; BISSACO, FERNANDA MAZON; CEFALI, LETICIA CARAMORI; OLIVEIRA-NASCIMENTO, LAURA; MAZZOLA, PRISCILA GAVA. Freeze-dried chitosan nanoparticles to stabilize and deliver bromelain. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v. 61, FEB 2021. (16/02282-1, 16/02287-3, 16/03444-5, 15/15068-5)