Genetic and phylodynamics diversity of emerging and re-emerging arboviruses (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil, 2014-2016

• Grant number: 16/08204-2
• Support Opportunities: Scholarships in Brazil - Doctorate
• Start date: August 01, 2016
• End date: March 31, 2019
• Field of knowledge: Biological Sciences - Microbiology - Biology and Physiology of Microorganisms
• Principal Investigator: Paolo Marinho de Andrade Zanotto
• Grantee: Marielton dos Passos Cunha
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Viruses transmitted by arthropods (arboviruses) are responsible for emerging and reemerging infectious diseases in different areas of the world, especially in tropical and subtropical regions. Among these viruses, we could highlight those belonging to the Flaviviridae and Togaviridae families, which may cause clinical manifestations ranging from asymptomatic infection, acute febrile to disease viral haemorrhagic fever and encephalitis. In Brazil, the virus that stand out are the Dengue virus (DENV), Chikungunya virus (CHIKV) and Zika virus (ZIKV), the last two first identified in 2014 and 2015 respectively, causing severe Public Health problems, especially in the Northeast region of Brazil. However, the processes that shape patterns of transmission in urban scales are unknown for these viruses, particularly the impact of factors such as the movement of the human population and urbanization. Elucidating the spread of emerging and reemerging arboviruses in Brazil in time and space is central to understanding of its epidemiology. In this context, this study aims to understand the dynamics of urban spread of emerging and re-emerging arbovirus (DENV, ZIKV and CHIKV) in the Northeast and Southeast regions of Brazil (states of Sergipe and São Paulo), and identify the demographics and socioeconomic factors associated with the dynamics of viral movement that can provide new opportunities for control and intervention strategies.

Scientific publications

(23)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 5, n. 49, DEC 2017. (14/17766-9, 16/08204-2, 13/22136-1)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Five Human Respiratory Syncytial Virus Isolates Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 7, FEB 2018. (14/17766-9, 16/08204-2, 13/22136-1)

SOARES-SCHANOSKI, ALESSANDRA; BAPTISTA CRUZ, NATALIA; DE CASTRO-JORGE, LUIZA ANTUNES; HOMEM DE CARVALHO, RENAN VILLANOVA; DOS SANTOS, CLIOMAR ALVES; DA ROS, NANCY; OLIVEIRA, URSULA; COSTA, DANUZA DUARTE; SIMOES DOS SANTOS, CECILIA LUIZA; CUNHA, MARIELTON DOS PASSOS; et al. Systems analysis of subjects acutely infected with the Chikungunya virus. PLOS PATHOGENS, v. 15, n. 6, JUN 2019. (12/19278-6, 13/07467-1, 15/25055-8, 13/08216-2, 16/08204-2, 17/50137-3)

CUNHA, MARIELTON DOS PASSOS; ORTIZ-BAEZ, AYDA SUSANA; DE MELO FREIRE, CAIO CESAR; DE ANDRADE ZANOTTO, PAOLO MARINHO. Codon adaptation biases among sylvatic and urban genotypes of Dengue virus type 2. INFECTION GENETICS AND EVOLUTION, v. 64, p. 207-211, OCT 2018. (13/25434-3, 16/08204-2)

DA CRUZ SILVA, JOAO PAULO; DOS PASSOS CUNHA, MARIELTON; POUR, SHAHAB ZAKI; HERING, VITOR RENAUX; DE LIMA NETO, DANIEL FERREIRA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Chikungunya Virus E2 Structural Protein B-Cell Epitopes Analysis. Viruses-Basel, v. 14, n. 8, p. 16-pg., 2022-08-01. (17/23281-6, 16/08204-2)

CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; DE SOUZA PEREIRA, BARBARA BRITO; HO, YEH-LI; PERONDI, BEATRIZ; SZTAJNBOK, JAQUES; FERREIRA ALVES, VENANCIO AVANCINI; FERRAZ DA SILVA, LUIZ FERNANDO; DOLHNIKOFF, MARISA; et al. Phylogeographic patterns of the yellow fever virus around the metropolitan region of Sao Paulo, Brazil, 2016-2019. PLoS Neglected Tropical Diseases, v. 16, n. 9, p. 16-pg., 2022-09-01. (17/23281-6, 16/08204-2)

VENCESLAU-CARVALHO, ALEXIA ADRIANNE; FAVARO, MARIANNA TEIXEIRA DE PINHO; PEREIRA, LENNON RAMOS; RODRIGUES-JESUS, MONICA JOSIANE; PEREIRA, SAMUEL SANTOS; ANDREATA-SANTOS, ROBERT; ALVES, RUBENS PRINCE DOS SANTOS; CASTRO-AMARANTE, MARIA FERNANDA; RODRIGUES, KARINE BITENCOURT; DA SILVA, JAMILE RAMOS; et al. Nano-multilamellar lipid vesicles loaded with a recombinant form of the chikungunya virus E2 protein improve the induction of virus-neutralizing antibodies. Nanomedicine-Nanotechnology Biology and Medicine, v. 37, OCT 2021. (17/23281-6, 16/19145-7, 16/08204-2, 17/24769-2, 16/20045-7, 16/23560-0)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Five Human Respiratory Syncytial Virus Isolates Collected in Brazil. GENOME ANNOUNCEMENTS, v. 6, n. 7, p. 2-pg., 2018-02-01. (14/17766-9, 16/08204-2, 13/22136-1)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequence of a Human Metapneumovirus Isolate Collected in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 6, FEB 2018. (14/17766-9, 16/08204-2, 13/22136-1)

OLIVEIRA, DANIELLE B. L.; DURIGON, GIULIANA S.; MENDES, ERICA A.; LADNER, JASON T.; ANDREATA-SANTOS, ROBERT; ARAUJO, DANIELLE B.; BOTOSSO, VIVIANE F.; PAOLA, NICHOLAS D.; NETO, DANIEL F. L.; CUNHA, MARIELTON P.; et al. Persistence and Intra-Host Genetic Evolution of Zika Virus Infection in Symptomatic Adults: A Special View in the Male Reproductive System. Viruses-Basel, v. 10, n. 11, NOV 2018. (13/07467-1, 14/17766-9, 14/27228-4, 14/16333-1, 16/08727-5, 15/25643-7, 14/03911-7, 16/08204-2, 16/20045-7, 13/26942-2, 16/03605-9)

DUARTE-NETO, AMARO NUNES; DE ALMEIDA MONTEIRO, RENATA APARECIDA; JOHNSSON, JANAINA; CUNHA, MARIELTON DOS PASSOS; POUR, SHAHAB ZAKI; SARAIVA, AMANDA CARTAGENES; HO, YEH-LI; FERRAZ DA SILVA, LUIZ FERNANDO; MAUAD, THAIS; DE ANDRADE ZANOTTO, PAOLO MARINHO; et al. Ultrasound-guided minimally invasive autopsy as a tool for rapid post-mortem diagnosis in the 2018 Sao Paulo yellow fever epidemic: Correlation with conventional autopsy. PLoS Neglected Tropical Diseases, v. 13, n. 7, JUL 2019. (16/08204-2)

CUNHA, MARIELTON DOS PASSOS; DOS SANTOS, CLIOMAR ALVES; DE LIMA NETO, DANIEL FERREIRA; SCHANOSKI, ALESSANDRA SOARES; POUR, SHAHAB ZAKI; PASSOS, SAULO DUARTE; FEITOSA DE SOUZAE, MERCIA SIMONE; COSTA, DANUZA DUARTE; DE ANDRADE ZANOTTO, PAOLO MARINHO. Outbreak of chikungunya virus in a vulnerable population of Sergipe, Brazil-A molecular and serological survey. Journal of Clinical Virology, v. 97, p. 44-49, DEC 2017. (16/08204-2, 14/17766-9, 16/03605-9)

CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; ORTIZ-BAEZ, AYDA SUSANA; CERNY, JIRI; DE SOUZA PEREIRA, BARBARA BRITO; BRACONI, CARLA TORRES; HO, YEH-LI; PERONDI, BEATRIZ; SZTAJNBOK, JAQUES; et al. Origin of the Sao Paulo Yellow Fever epidemic of 2017-2018 revealed through molecular epidemiological analysis of fatal cases. SCIENTIFIC REPORTS, v. 9, DEC 31 2019. (17/23281-6, 13/25434-3, 13/21728-2, 16/08204-2)

CUNHA, MARIELTON DOS PASSOS; DUARTE-NETO, AMARO NUNES; POUR, SHAHAB ZAKI; HAJJAR, LUDHMILA ABRAHAO; FRASSETTO, FERNANDO PEREIRA; DOLHNIKOFF, MARISA; DO NASCIMENTO SALDIVA, PAULO HILARIO; DE ANDRADE ZANOTTO, PAOLO MARINHO. Systemic dengue infection associated with a new dengue virus type 2 introduction in Brazil - a case report. BMC INFECTIOUS DISEASES, v. 21, n. 1, APR 1 2021. (20/04602-9, 13/21728-2, 17/23281-6, 16/08204-2)

CUNHA, MARIELTON DOS PASSOS; IOSHINO, RAFAELLA SAYURI; COSTA-DA-SILVA, ANDRE LUIS; PETERSEN, VIVIAN; CAPURRO, MARGARETH LARA; ZANOTTO, PAOLO MARINHO DE ANDRADE. A Metagenomic Approach Identified a Novel Phasi Charoen- Like Virus Coinfecting a Chikungunya Virus-Infected Aedes aegypti Mosquito in Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 9, n. 31, JUL 2020. (17/23281-6, 16/08204-2)

BARBOSA, CARLA M.; DI PAOLA, NICHOLAS; CUNHA, MARIELTON P.; RODRIGUES-JESUS, MONICA J.; ARAUJO, DANIELLE B.; SILVEIRA, VANESSA B.; LEAL, FABYANO B.; MESQUITA, FLAVIO S.; BOTOSSO, VIVIANE F.; ZANOTTO, PAOLO M. A.; et al. Yellow Fever Virus RNA in Urine and Semen of Convalescent Patient, Brazil. Emerging Infectious Diseases, v. 24, n. 1, p. 176-178, JAN 2018. (14/17766-9, 14/21141-4, 16/08727-5, 13/22136-1, 16/08204-2)

ORTIZ-BAEZ, AYDA SUSANA; CUNHA, MARIELTON DOS PASSOS; VEDOVELLO, DANILA; COLOMBO, TATIANA ELIAS; NOGUEIRA, MAURICIO LACERDA; VILLABONA-ARENAS, CHRISTIAN JULIAN; DE ANDRADE ZANOTTO, PAOLO MARINHO. Origin, tempo, and mode of the spread of DENV-4 Genotype IIB across the state of São Paulo, Brazil during the 2012-2013 outbreak. Memórias do Instituto Oswaldo Cruz, v. 114, 2019. (13/25434-3, 16/08204-2, 11/17071-2)

COSTA-DA-SILVA, ANDRE LUIS; IOSHINO, RAFAELLA SAYURI; PETERSEN, VIVIAN; LIMA, ANTONIO FERNANDO; CUNHA, MARIELTON DOS PASSOS; WILEY, MICHAEL R.; LADNER, JASON T.; PRIETO, KARLA; PALACIOS, GUSTAVO; COSTA, DANUZA DUARTE; et al. First report of naturally infected Aedes aegypti with chikungunya virus genotype ECSA in the Americas. PLoS Neglected Tropical Diseases, v. 11, n. 6, JUN 2017. (13/19921-9, 16/08204-2, 14/17766-9, 14/27172-9)

DOMBROWSKI, JAMILLE GREGORIO; DE SOUZA, RODRIGO MEDEIROS; LIMA, FLAVIA AFONSO; BANDEIRA, CARLA LETICIA; MURILLO, OSCAR; COSTA, DOUGLAS DE SOUSA; MACHADO PEIXOTO, ERIKA PAULA; CUNHA, MARIELTON DOS PASSOS; DE ANDRADE ZANOTTO, PAOLO MARINHO; BEVILACQUA, ESTELA; et al. Association of Malaria Infection During Pregnancy With Head Circumference of Newborns in the Brazilian Amazon. JAMA NETWORK OPEN, v. 2, n. 5, MAY 2019. (14/17766-9, 18/20468-0, 12/04755-3, 13/21728-2, 14/20451-0, 14/09964-5, 15/06106-0, 13/00981-1, 16/08204-2, 13/16417-8, 09/53889-0)

DIENG, IDRISSA; DOS PASSOS CUNHA, MARIELTON; DIAGNE, MOUSSA MOISE; SEMBENE, PAPE MBACKE; DE ANDRADE ZANOTTO, PAOLO MARINHO; FAYE, OUSMANE; FAYE, OUMAR; SALL, AMADOU ALPHA. Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019. Viruses-Basel, v. 13, n. 1, JAN 2021. (16/08204-2, 17/23281-6)

DUARTE-NETO, AMARO N.; CUNHA, MARIELTON DOS P.; MARCILIO, IZABEL; SONG, ALICE T. W.; DE MARTINO, RODRIGO B.; HO, YEH-LI; POUR, SHAHAB Z.; DOLHNIKOFF, MARISA; SALDIVA, PAULO H. N.; DUARTE, MARIA I. S.; et al. Yellow fever and orthotopic liver transplantation: new insights from the autopsy room for an old but re-emerging disease. Histopathology, v. 75, n. 5, p. 638-648, NOV 2019. (16/08204-2)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL DE OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequences of Two Human Parainfluenza Virus Type 3 Isolates Collected in Brazil. GENOME ANNOUNCEMENTS, v. 5, n. 49, p. 2-pg., 2017-12-01. (14/17766-9, 16/08204-2, 13/22136-1)

DI PAOLA, NICHOLAS; CUNHA, MARIELTON DOS PASSOS; DURIGON, GIULIANA STRAVINSKAS; BEREZIN, EITAN NAAMAN; DURIGON, EDISON; LEAL OLIVEIRA, DANIELLE BRUNA; DE ANDRADE ZANOTTO, PAOLO MARINHO. Complete Genome Sequence of a Human Metapneumovirus Isolate Collected in Brazil. GENOME ANNOUNCEMENTS, v. 6, n. 6, p. 2-pg., 2018-02-01. (14/17766-9, 16/08204-2, 13/22136-1)