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Bioactive metabolites from Nectandra oppositifolia Ness. & Mart. (Lauraceae) - molecular characterization, in vitro and in vivo antiparasitic potential evaluation and determination of mechanism of action

Grant number: 16/20633-6
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): January 01, 2017
Effective date (End): June 30, 2020
Field of knowledge:Physical Sciences and Mathematics - Chemistry
Principal Investigator:João Henrique Ghilardi Lago
Grantee:Geanne Alexsandra Alves Conserva
Home Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Associated scholarship(s):18/18975-1 - Dereplication profile of Nectandra oppositifolia Nees & Mart (Lauraceae) - identification and molecular caracterization of antiparasitic metabolites, BE.EP.DR


Plants are used for medicinal purposes since ancient times. Natural compounds extracted from plants have been highlighted as important sources of new therapeutic agents, used in the treatment of several ills, especially neglected diseases, such as leishmaniosis, Chagas disease among others. In this aspect, several studies are directed to evaluation of biological activities of natural compounds from plants, as well as investigation of mechanism of action of potential bioactive compounds. In this context, this project aims the isolation, purification and structural identification and/or elucidation of compounds with antiparasitic activity (antileishmanial and trypanocidal) from extracts of leaves and branches of Nectandra oppositifolia Ness & Mart (Lauraceae), specie still unknown in chemical point of view. Therefore, a phytochemical dereplication study will be conducted, followed by a bioactivity-guided fractionation, aiming the isolation and structural characterization of compounds present in the active extracts, which will be re-evaluated against those activities observed for crude extracts.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA-SILVA, THAIS A.; ALVES CONSERVA, GEANNE A.; GALISTEO, JR., ANDRES J.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G. Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae). Journal of Venomous Animals and Toxins including Tropical Diseases, v. 25, AUG 19 2019. Web of Science Citations: 0.
ALVES CONSERVA, GEANNE A.; DA COSTA-SILVA, THAIS A.; AMARAL, MAIARA; ANTAR, GUILHERME M.; NEVES, BRUNO J.; ANDRADE, CAROLINA H.; TEMPONE, ANDRE G.; LAGO, JOAO HENRIQUE G. Butenolides from Nectandra oppositifolia (Lauraceae) displayed anti-Trypanosoma cruzi activity via deregulation of mitochondria. Phytomedicine, v. 54, p. 302-307, FEB 15 2019. Web of Science Citations: 1.

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