| Grant number: | 16/20633-6 |
| Support type: | Scholarships in Brazil - Doctorate |
| Effective date (Start): | January 01, 2017 |
| Effective date (End): | December 31, 2020 |
| Field of knowledge: | Physical Sciences and Mathematics - Chemistry - Organic Chemistry |
| Principal Investigator: | João Henrique Ghilardi Lago |
| Grantee: | Geanne Alexsandra Alves Conserva |
| Home Institution: | Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil |
| Associated scholarship(s): | 18/18975-1 - DEREPLICATION PROFILE OF Nectandra oppositifolia Nees & Mart (LAURACEAE) - IDENTIFICATION AND MOLECULAR CARACTERIZATION OF ANTIPARASITIC METABOLITES, BE.EP.DR |
Abstract Plants are used for medicinal purposes since ancient times. Natural compounds extracted from plants have been highlighted as important sources of new therapeutic agents, used in the treatment of several ills, especially neglected diseases, such as leishmaniosis, Chagas disease among others. In this aspect, several studies are directed to evaluation of biological activities of natural compounds from plants, as well as investigation of mechanism of action of potential bioactive compounds. In this context, this project aims the isolation, purification and structural identification and/or elucidation of compounds with antiparasitic activity (antileishmanial and trypanocidal) from extracts of leaves and branches of Nectandra oppositifolia Ness & Mart (Lauraceae), specie still unknown in chemical point of view. Therefore, a phytochemical dereplication study will be conducted, followed by a bioactivity-guided fractionation, aiming the isolation and structural characterization of compounds present in the active extracts, which will be re-evaluated against those activities observed for crude extracts. | |