Influence of genetics polymorphisms in effects of two types of high intensity aerobic interval training in patients with metabolic syndrome

• Grant number: 16/17586-6
• Support Opportunities: Scholarships abroad - Research
• Start date: November 19, 2016
• End date: February 18, 2017
• Field of knowledge: Health Sciences - Physical Education
• Principal Investigator: Carlos Roberto Bueno Júnior
• Grantee: Carlos Roberto Bueno Júnior
• Host Investigator: Arnt Erik Tjonna
• Host Institution: Escola de Educação Física e Esporte de Ribeirão Preto (EEFERP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
• Institution abroad: Norwegian University of Science and Technology (NTNU), Norway

Abstract

Recent studies have demonstrated that metabolic syndrome (MS) prevalence is over 35% in Brazil and aerobic training (AT) is an important non pharmacological therapy for MS. Although the majority of professionals prescribe 150 min of moderate intensity AT per week, it has been speculated that high intensity interval AT can result in superior benefits. Furthermore, a clear indication of minimum time required for optimized benefits in a single AT session needs to be investigated. Finally, the responsiveness to AT varies among different patients, which can be explained by genetic variations. Therefore, the purposes of this study are: 1) to evaluate in MS patients health parameters related to the disease and maximal oxygen uptake, analyzing the effects of high intensity interval AT (it will be tested two different volumes) versus moderate intensity AT and 2) to screen for polymorphisms in ACE, AGTR1, AKT1 and visfatin genes and evaluate their relationship to exercise responsiveness to the three types of AT. It is also an aim of this study to perform microRNAs expression profile (adipose and muscle tissue) and exome sequencing in these patients. Males and females MS patients (age e 30) will be randomized and stratified (age and sex) in three groups: interval AT three times a week, 4x4min (90% of maximum heart rate - HRmax); interval AT three times a week, 1x4 min (90% HRmax); and traditional AT (70% HR max for at least 30min and 5 days a week). Sample size will be estimated based on the variability from a pilot study (n=10 per group). The results of this study will provide important issues to genetic characteristics to be considered in the choice of the more efficient AT for each patient.