Application of factorial design 2(4) for optimization of the encapsulation efficiency Eugenia aurata phenolic compounds

• Grant number: 16/20159-2
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: January 01, 2017
• End date: December 31, 2017
• Field of knowledge: Engineering - Chemical Engineering - Chemical Technology
• Principal Investigator: Catarina dos Santos
• Grantee: Murilo Henrique Maciel de Camargo
• Host Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil

Abstract

Medicinal plants have been used during the history of mankind to treat diseases, mainly in developing countries. In this context, the study of potencial of these plants became attractive for pharmaceutical and cosmetic industries. Cerrado, one of the main areas of biodiversity, offers a wide range of plants for these types of applications. Among the various species of this biome, there is the genus Eugenia, it is considered one of the biggest of the family Myrtaceae, with the presence of flavonoids, tannins, terpenoids and essential oils, which have several reported bioactivities, such as gastroprotective, antinociceptive, anti-inflammatory, analgesic, antifungal, antipyretic, anti-diabetic and anti-oxidants. However, these phenolic compounds have been reported in the literature as unstable and susceptible to degradation by oxygen, light, pH and temperature. A solution to this limitation is the microencapsulation, it can improve the stability of phenolic compounds, protecting them, and improve their time of release. In order to rationalize this procedure, it is essential to use factorial design, because it will provide a lot of information about the process, take less time, effort, resources and minimize the number of experiences. Then the objective of this study is to obtain better efficiency of microencapsulation of phenolic compounds of hydroethanolic extracts of Eugenia aurata via factorial design 24 using as variables two gums (maltodextrin Neomalt: 5020 B and Satialginite S1100 alginate), phenols contents in two seasons of the year (rainy and dry), two hydroethanolic extracts (70% and 100%) and two proportions encapsulated material: gum (1: 1 to 1: 4). (AU)