Electrical stimulation effect on coronally advanced flap for the treatment of gingival recession: randomized controlled clinical trial

• Grant number: 16/07528-9
• Support Opportunities: Scholarships in Brazil - Doctorate
• Effective date (Start): January 01, 2017
• Effective date (End): January 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Mauro Pedrine Santamaria
• Grantee: Felipe Lucas da Silva Neves
• Host Institution: Instituto de Ciência e Tecnologia (ICT). Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. São José dos Campos , SP, Brazil

Abstract

Gingival recession is a very common problem in the dental clinic, which may affect up to 100% of the population and often associated with dentinal sensitivity and aesthetic problems. As a result, many surgical techniques were developed to deal with this problem. Even the best surgical techniques present a great variability in their results, and not all patients feel completely satisfied with the final esthetic outcome. One of the reasons that may explain this variation is the differences in the wound healing process of each patient. Many strategies have been used in an attempt to accelerate healing, one is the application of an exogenous electrical stimulation to activate tissue repair, whose understanding of the effects on clinical outcomes and on the molecular level of immunological biomarkers in gingival healing may represent a new treatment protocol in the periodontal plastic surgery arsenal. The objective of this study is to evaluate clinically and through the concentration of inflammatory markers, the results of 6 months of electrical stimulation associated with coronally advanced flap for treatment of gingival recession. For this, a double-blind randomized clinical trial will be carried out following the CONSORT STATEMENT 2010. Sixty patients presenting gingival recession will be divided in 2 groups: CAF group: coronally advanced flap for root coverage and sham electrical stimulation; CAF+E: coronally advanced flap for root coverage plus electrical stimulation. Clinical, esthetics, and comfort of patients parameters will be assessed at baseline and after 3 and 6 months after the procedure. Inflammatory biomarkers and growth factors will be assessed at baseline and 14, 45 e 180 days after the procedure.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VIANA MIGUEL, MANUELA MARIA; MATHIAS-SANTAMARIA, INGRID FERNANDES; ROSSATO, AMANDA; FERREIRA FERRAZ, LAIS FERNANDA; FIGUEIREDO-NETO, ANTONIO MARTINS; DE MARCO, ANDREA CARVALHO; VIANA CASARIN, RENATO CORREA; WALLET, SHANNON MARGARET; TATAKIS, DIMITRIS N.; MATHIAS, MARCIO ANTONIO; et al. Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial. Journal of Periodontology, v. 92, n. 2, AUG 2020. (18/03353-5, 18/07340-5, 16/16102-5, 16/07528-9, 16/24531-3, 14/50983-3)

FERREIRA, CAMILA LOPES; NEVES JARDINI, MARIA APARECIDA; MORETTO NUNES, CAMILLA MAGNONI; BERNARDO, DANIELLA VICENSOTTO; VIANA CASARIN, RENATO CORREA; GEDRAITE, ESTEVAO DOS SANTOS; MATHIAS, MARCIO ANTONIO; LIU, FEI; MENDONCA, GUSTAVO; SILVEIRA MENDONCA, DANIELA BACCELLI; et al. Electrical stimulation enhances early palatal wound healing in mice. ARCHIVES OF ORAL BIOLOGY, v. 122, FEB 2021. (16/07528-9, 16/16102-5)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

NEVES, Felipe Lucas da Silva. Electrical stimulation effect on coronally advanced flap for the treatment of gingival recession: randomized controlled clinical trial. 2019. Doctoral Thesis - Universidade Estadual Paulista (Unesp). Instituto de Ciência e Tecnologia. São José dos Campos São José dos Campos.