Bromelain encapsulation: characterization and stability

• Grant number: 17/05333-9
• Support Opportunities: Scholarships abroad - Research Internship - Scientific Initiation
• Start date: August 31, 2017
• End date: November 29, 2017
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Eloah Favero Gérios
• Supervisor: Eliana Maria Barbosa Souto
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Universidade de Coimbra (UC), Portugal
• Associated to the scholarship: 16/02282-1 - Stability and release study of encapsulated bromelain in chitosan nanoparticles, BP.IC

Abstract

Nanoparticles are carrier systems for organic compounds, which are considered promising for facilitating the bioavailability of these compounds in pharmaceutical forms, being used as a strategy to increase safety, efficacy and stability. Bromelain, in turn, is a protein found in pineapple (Bromeliaceae family), which has proteolytic, healing, anti-cancer, and anti-inflammatory activities, among others, being used in the pharmaceutical, food and textile industries. Bromelain encapsulation in order to improve its stability in pharmaceutical products is still unclear, so this project aims to study the stability of encapsulated bromelain under stress conditions, as well as the comparison of these with chitosan nanoparticles. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; MAZZOLA, PRISCILA GAVA; SOUTO, ELIANA B.. Bromelain-loaded nanoparticles: A comprehensive review of the state of the art. ADVANCES IN COLLOID AND INTERFACE SCIENCE, v. 254, p. 48-55, APR 2018. (17/05333-9, 16/03444-5, 17/05275-9)

ATAIDE, JANAINA ARTEM; GERIOS, ELOAH FAVERO; CEFALI, LETICIA CARAMORI; FERNANDES, ANA RITA; TEIXEIRA, MARIA DO CEU; FERREIRA, NUNO R.; TAMBOURGI, ELIAS BASILE; JOZALA, ANGELA FAUSTINO; CHAUD, MARCO VINICIUS; OLIVEIRA-NASCIMENTO, LAURA; et al. Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain-Chitosan Nanoparticles. POLYMERS, v. 11, n. 10, OCT 2019. (17/05333-9, 16/03444-5, 17/05275-9)