In situ evaluation of the anti-erosive effect of the association between sodium fluoride and propylene glycol alginate

• Grant number: 17/09408-3
• Support Opportunities: Scholarships in Brazil - Master
• Start date: March 01, 2018
• End date: March 31, 2019
• Field of knowledge: Health Sciences - Dentistry - Dental Clinics
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Taís Scaramucci Forlin
• Grantee: Letícia Oba Sakae
• Host Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The aim of this study is to evaluate the anti-erosive effect of solutions contaning sodium fluoride (F: 225 ppm F), sodium fluoride + stannous chloride (F+Sn: 225 ppm F + 800 ppm Sn), sodium fluoride + propylene glycol alginate (F+PGA: 225 ppm F + 0,1% PGA), and deionized water (negative control), using a 4-phase, split mouth, single bind, cross over in situ trial. Twelve subjects will participate in the study after signing a written informed consent. In each study phase, the subjects will use removable mandible devices containing 4 enamel specimens, which will submitted to an erosion-remineralization-abrasion or erosion-remineralization cycling model (split mouth) of 5 days. The erosion-remineralization-abrasion cycling will consist of 5 min extra-oral immersion in 1% citric acid (pH=2.6), followed by 120 min remineralization in situ. This procedure will be repeated 4x/day. Treatment with the test solutions will be performed 2x/day, after the first and the last erosive challenges. Before treatment, toothbrushing will be performed with an electric toothbrush and a dentifrice slurry (1450 ppm F) for 5 s, in a total of 2 min exposure to the slurry. or the erosion-remineralization cycling, there will only 2 min exposure to the slurry, without brushing. At the end, enamel surface loss (in µm) will be evaluated with optical profilometry. Surface loss data will be analyzed with ANOVA suitable for crossover studies and Tukey, or Krukal-wallis and Tukey, depending on the normality and homoscedasticity distribution of the data. The significance level will be set at 5%. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACHADO, ALANA; SAKAE, LETICIA; NIEMEYER, SAMIRA HELENA; CARVALHO, THIAGO SAADS; AMAECHI, BENNETT; SCARAMUCCI, TAIS. Anti-erosive effect of rinsing before or after toothbrushing with a Fluoride/Stannous Ions solution: an in situ investigation Application order of Fluoride/Tin products for erosive tooth wear. Journal of Dentistry, v. 101, p. 6-pg., 2020-10-01. (17/09408-3, 17/24714-3)

SAKAE, LETICIA OBA; NIEMEYER, SAMIRA HELENA; CARDOSO BEZERRA, SAVIO JOSE; BORGES, ALESSANDRA BUHLER; TURSSI, CECILIA PEDROSO; SCARAMUCCI, TAIS. The Addition of Propylene Glycol Alginate to a Fluoride Solution to Control Enamel Wear: An in situ Study. Caries Research, v. 54, n. 5-6, NOV 2020. (17/09408-3)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

SAKAE, Letícia Oba. In situ evaluation of the anti-erosive effect of the association of sodium fluoride with propylene glycol alginate. 2019. Master's Dissertation - Universidade de São Paulo (USP). Faculdade de Odontologia (FO/SDO) São Paulo.