Development of electrochemical sensors based on magnetic nanoparticles coated with molecular imprinting polymers for sensitive and selective determination of folic acid and its metabolites in different samples

• Grant number: 18/09432-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2018
• End date: December 31, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Maria Del Pilar Taboada Sotomayor
• Grantee: Sara Manente Garcia
• Host Institution: Instituto de Química (IQ). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated research grant: 14/50945-4 - INCT 2014: National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactivies, AP.TEM

Abstract

The present project aims the development of an analytical method based on biomimetic systems for the determination of folic acid and its metabolites. The construction of the biomimetic system will be carried out with the molecularly printed polymers (MIPs). The MIPs will be synthesized on metallic nanoparticles by precipitation method, and characterized by scanning electron microscopy, infrared spectroscopy, and BET (Bunauer-Emmett-Teller) method. The magneto-MIPs will be evaluated in rebinding tests (analyte: polymer), and after their efficiency has been proven, these materials will be used as modifiers in electrochemical sensors (magneto-MIP / sensor). It is expected that the developed magneto-MIPs will become an ideal material for sensitive and selective analysis of folic acid and its metabolites in food, biological, and environmental samples. The results obtained with the electrochemical method will be compared with the reference method (HPLC-UV).

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

GARCIA, SARA MANENTE; WONG, ADEMAR; KHAN, SABIR; SOTOMAYOR, MARIA D. P. T.. A simple, sensitive and efficient electrochemical platform based on carbon paste electrode modified with Fe3O4@MIP and graphene oxide for folic acid determination in different matrices. Talanta, v. 229, JUL 1 2021. (18/09432-4, 19/00677-7)