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Evaluation of metabolic parameters of experimental animal models in response to dietary interesterified fat: underlaying molecular mechanisms

Grant number: 16/24768-3
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2018
Effective date (End): February 28, 2021
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Marciane Milanski Ferreira
Grantee:Josiane Érica Miyamoto
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID


The actual dietary pattern is characterized by high consumption of processed food which contains high content of lipids, including trans fatty acids. The excess of these type of fatty acids in the diet can rise LDL-c levels and is related to coronary diseases and diabetes. Nowadays, interesterified fats have been used as an alternative to substitute the trans fat once this was proved to be able to modulate the lipid profile and then predisposing to cardiovascular disease. The chemical process of interestrification of oils and fat rearranges fatty acids in triglycerides and promote changes in its structure, this process allows the food industry to produce plastic fats. Lipids are known to be involved in many process of regulation of homeostasis and in several cellular activities and there is well established that the excess of this dietary component can lead to development of obese phenotype and it consequences, but the role of interesterified fat in metabolism is not elucidated. Therefore, the aim of this work is to evaluate the dietary sources of lipids and their role on metabolic parameters and underlying molecular mechanisms that are involved in response of dietary interesterified fat obtained from chemical randomization in animal models. (AU)