CHARACTERIZATION OF SYNTHETIC DRUGS AS ADULTERANTS IN DIETARY SUPPLEMENTS: USE OF VOLTAMMETRY OF IMMOBILIZED MICROPARTICLES IN SOLID STATE AS ANALYTICAL METHODOLOGY

• Grant number: 18/13496-8
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: January 01, 2019
• End date: July 18, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: José Alberto Fracassi da Silva
• Grantee: Géssica Domingos da Silveira
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis, AP.TEM

Abstract

The voltammetry of immobilized microparticles (VIMP) is a technique that allows the study of electrochemical processes and the characterization of solid substances immobilized by abrasion on the surface of an inert electrode wherein paraffin impregnated graphite electrode (PIGE) is the most used. In recent years, this technique has received special attention in the characterization of organic compounds, representing an important step in the applicability of electrochemistry. It allows obtaining relevant information of the electrochemical process in solid state of many compounds or material provided that it does not dissolve in the electrolyte solution. In parallel to this, the increasing adulteration of food supplements with synthetic drugs raises the need for the development and application of simple and low cost techniques aimed at an efficient quality control by regulatory agencies. In Brazil, the lack of specific legislation allows the indiscriminate commercialization of dietary supplements adulterated with synthetic drugs in order to increase the performance and the appeal by which these products are sold, resulting in a great risk to the health of the consumer. Thus, VIMP could be used as a promising analytical tool on the qualitative and semi-quantitative screening of possible adulterating drugs in these matrices. Moreover, electrodes modified with metallic nanoparticles have not been used yet in VIMP applications, and these electrodes can provide a better selectivity when compared to the commonly used graphite electrodes. In addition, the oxidation/reduction products and the morphological changes of the solid particles resulting from the solid-state electrochemical processes can be characterized by auxiliary techniques such as scanning electrochemical microscopy and or scanning electron microscopy, providing relevant information on the electrochemical mechanisms of the studied drugs, which, despite their importance, are little discussed in the literature.

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical analysis of organic compounds in solid-state: applications of voltammetry of immobilized microparticles in bioanalysis and cultural heritage science. Journal of Solid State Electrochemistry, JUN 2020. (14/50867-3, 18/06478-3, 18/13496-8)

DA SILVEIRA, GESSICA DOMINGOS; DI TURO, FRANCESCA; DIAS, DAIANE; DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical analysis of organic compounds in solid-state: applications of voltammetry of immobilized microparticles in bioanalysis and cultural heritage science. Journal of Solid State Electrochemistry, v. 24, n. 11-12, p. 20-pg., 2020-06-18. (18/06478-3, 18/13496-8, 14/50867-3)

MUNARETTO DURIGON, ANA MARIA; DA SILVEIRA, GESSICA DOMINGOS; SOKAL, FLAVIO ROBERTO; CAPA VERDE PIRES, RONI ANDERSON; DIAS, DAIANE. Food dyes screening using electrochemistry approach in solid state: the case of sunset yellow dye electrochemical behavior. Journal of Solid State Electrochemistry, JUN 2020. (18/13496-8)

DA SILVEIRA, GESSICA DOMINGOS; BRESSAN, LUCAS PANES; SCHMIDT, MARCELLA EMILIA PETRA; DAL MOLIN, THAIS RAMOS; TEIXEIRA, CARLOS ALBERTO; POPPI, RONEI JESUS; DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles. Journal of Solid State Electrochemistry, v. 24, n. 8, SI, APR 2020. (14/50867-3, 18/06478-3, 18/13496-8)

QUERO, REVERSON FERNANDES; DA SILVEIRA, GESSICA DOMINGOS; FRACASSI DA SILVA, JOSE ALBERTO; DE JESUS, DOSIL PEREIRA. nderstanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic device. LAB ON A CHIP, v. 21, n. 19, JUL 2021. (18/06478-3, 14/50867-3, 13/22127-2, 18/13496-8)

DA SILVEIRA, GESSICA DOMINGOS; QUERO, REVERSON FERNANDES; BRESSAN, LUCAS PAINES; BONACIN, JULIANO ALVES; DE JESUS, DOSIL PEREIRA; DA SILVA, ALBERTO FRACASSI. Ready-to-use 3D-printed electrochemical cell for in situ voltammetry of immobilized microparticles and Raman spectroscopy. Analytica Chimica Acta, v. 1141, p. 57-62, JAN 2 2021. (14/50867-3, 18/06478-3, 18/13496-8, 13/22127-2)

BRESSAN, LUCAS P.; LIMA, TAISSA M.; DA SILVEIRA, GESSICA D.; DA SILVA, JOSE A. F.. Low-cost and simple FDM-based 3D-printed microfluidic device for the synthesis of metallic core-shell nanoparticles. SN APPLIED SCIENCES, v. 2, n. 5, MAY 2020. (14/50906-9, 18/06478-3, 18/13496-8)

MACIEL, JULIANA VILLELA; DA SILVEIRA, GESSICA DOMINGOS; DURIGON, ANA MARIA MUNARETTO; FATIBELLO-FILHO, ORLANDO; DIAS, DAIANE. Use of carbon black based electrode as sensor for solid-state electrochemical studies and voltammetric determination of solid residues of lead. Talanta, v. 236, JAN 1 2022. (11/13312-5, 18/13496-8)

AGUSTINI, DEONIR; CAETANO, FABIO ROBERTO; QUERO, REVERSON FERNANDES; FRACASSI DA SILVA, JOSE ALBERTO; BERGAMINI, MARCIO FERNANDO; MARCOLINO-JUNIOR, LUIZ HUMBERTO; DE JESUS, DOSIL PEREIRA. Microfluidic devices based on textile threads for analytical applications: state of the art and prospects. ANALYTICAL METHODS, v. 13, n. 41, SEP 2021. (13/22127-2, 14/50867-3, 18/13496-8, 18/06478-3)

QUERO, REVERSON FERNANDES; DE JESUS, DOSIL PEREIRA; DA SILVA, JOSE ALBERTO FRACASSI. Simple modification to allow high-efficiency and high-resolution multi-material 3D-printing fabrication of microfluidic devices. LAB ON A CHIP, v. 23, n. 16, p. 10-pg., 2023-07-07. (18/06478-3, 18/13496-8, 13/22127-2, 14/50867-3)

DA SILVEIRA, GESSICA DOMINGOS; BRESSAN, LUCAS PANES; SCHMIDT, MARCELLA EMILIA PETRA; DAL MOLIN, THAIS RAMOS; TEIXEIRA, CARLOS ALBERTO; POPPI, RONEI JESUS; DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles. Journal of Solid State Electrochemistry, v. 24, n. 8, p. 12-pg., 2020-04-06. (18/06478-3, 18/13496-8, 14/50867-3)

MUNARETTO DURIGON, ANA MARIA; DA SILVEIRA, GESSICA DOMINGOS; SOKAL, FLAVIO ROBERTO; CAPA VERDE PIRES, RONI ANDERSON; DIAS, DAIANE. Food dyes screening using electrochemistry approach in solid state: the case of sunset yellow dye electrochemical behavior. Journal of Solid State Electrochemistry, v. 24, n. 11-12, p. 15-pg., 2020-06-03. (18/13496-8)