CHARACTERIZATION OF SYNTHETIC DRUGS AS ADULTERANTS IN DIETARY SUPPLEMENTS: USE OF VOLTAMMETRY OF IMMOBILIZED MICROPARTICLES IN SOLID STATE AS ANALYTICAL METHODOLOGY

• Grant number: 18/13496-8
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): January 01, 2019
• Effective date (End): July 18, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal researcher: José Alberto Fracassi da Silva
• Grantee: Géssica Domingos da Silveira
• Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 14/50867-3 - INCT 2014: National Institute of Science and Technology in Bioanalysis, AP.TEM

Abstract

The voltammetry of immobilized microparticles (VIMP) is a technique that allows the study of electrochemical processes and the characterization of solid substances immobilized by abrasion on the surface of an inert electrode wherein paraffin impregnated graphite electrode (PIGE) is the most used. In recent years, this technique has received special attention in the characterization of organic compounds, representing an important step in the applicability of electrochemistry. It allows obtaining relevant information of the electrochemical process in solid state of many compounds or material provided that it does not dissolve in the electrolyte solution. In parallel to this, the increasing adulteration of food supplements with synthetic drugs raises the need for the development and application of simple and low cost techniques aimed at an efficient quality control by regulatory agencies. In Brazil, the lack of specific legislation allows the indiscriminate commercialization of dietary supplements adulterated with synthetic drugs in order to increase the performance and the appeal by which these products are sold, resulting in a great risk to the health of the consumer. Thus, VIMP could be used as a promising analytical tool on the qualitative and semi-quantitative screening of possible adulterating drugs in these matrices. Moreover, electrodes modified with metallic nanoparticles have not been used yet in VIMP applications, and these electrodes can provide a better selectivity when compared to the commonly used graphite electrodes. In addition, the oxidation/reduction products and the morphological changes of the solid particles resulting from the solid-state electrochemical processes can be characterized by auxiliary techniques such as scanning electrochemical microscopy and or scanning electron microscopy, providing relevant information on the electrochemical mechanisms of the studied drugs, which, despite their importance, are little discussed in the literature.

Scientific publications

(6)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

QUERO, REVERSON FERNANDES; DA SILVEIRA, GESSICA DOMINGOS; FRACASSI DA SILVA, JOSE ALBERTO; DE JESUS, DOSIL PEREIRA. Understanding and improving FDM 3D printing to fabricate high-resolution and optically transparent microfluidic devices. LAB ON A CHIP, JUL 2021. Web of Science Citations: 0.

DA SILVEIRA, GESSICA DOMINGOS; QUERO, REVERSON FERNANDES; BRESSAN, LUCAS PAINES; BONACIN, JULIANO ALVES; DE JESUS, DOSIL PEREIRA; DA SILVA, ALBERTO FRACASSI. Ready-to-use 3D-printed electrochemical cell for in situ voltammetry of immobilized microparticles and Raman spectroscopy. Analytica Chimica Acta, v. 1141, p. 57-62, JAN 2 2021. Web of Science Citations: 0.

DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical analysis of organic compounds in solid-state: applications of voltammetry of immobilized microparticles in bioanalysis and cultural heritage science. Journal of Solid State Electrochemistry, JUN 2020. Web of Science Citations: 0.

MUNARETTO DURIGON, ANA MARIA; DA SILVEIRA, GESSICA DOMINGOS; SOKAL, FLAVIO ROBERTO; CAPA VERDE PIRES, RONI ANDERSON; DIAS, DAIANE. Food dyes screening using electrochemistry approach in solid state: the case of sunset yellow dye electrochemical behavior. Journal of Solid State Electrochemistry, JUN 2020. Web of Science Citations: 0.

BRESSAN, LUCAS P.; LIMA, TAISSA M.; DA SILVEIRA, GESSICA D.; DA SILVA, JOSE A. F. Low-cost and simple FDM-based 3D-printed microfluidic device for the synthesis of metallic core-shell nanoparticles. SN APPLIED SCIENCES, v. 2, n. 5 MAY 2020. Web of Science Citations: 0.

DA SILVEIRA, GESSICA DOMINGOS; BRESSAN, LUCAS PANES; SCHMIDT, MARCELLA EMILIA PETRA; DAL MOLIN, THAIS RAMOS; TEIXEIRA, CARLOS ALBERTO; POPPI, RONEI JESUS; DA SILVA, JOSE ALBERTO FRACASSI. Electrochemical behavior of 5-type phosphodiesterase inhibitory drugs in solid state by voltammetry of immobilized microparticles. Journal of Solid State Electrochemistry, v. 24, n. 8, SI APR 2020. Web of Science Citations: 2.