The voltammetry of immobilized microparticles (VIMP) is a technique that allows the study of electrochemical processes and the characterization of solid substances immobilized by abrasion on the surface of an inert electrode wherein paraffin impregnated graphite electrode (PIGE) is the most used. In recent years, this technique has received special attention in the characterization of organic compounds, representing an important step in the applicability of electrochemistry. It allows obtaining relevant information of the electrochemical process in solid state of many compounds or material provided that it does not dissolve in the electrolyte solution. In parallel to this, the increasing adulteration of food supplements with synthetic drugs raises the need for the development and application of simple and low cost techniques aimed at an efficient quality control by regulatory agencies. In Brazil, the lack of specific legislation allows the indiscriminate commercialization of dietary supplements adulterated with synthetic drugs in order to increase the performance and the appeal by which these products are sold, resulting in a great risk to the health of the consumer. Thus, VIMP could be used as a promising analytical tool on the qualitative and semi-quantitative screening of possible adulterating drugs in these matrices. Moreover, electrodes modified with metallic nanoparticles have not been used yet in VIMP applications, and these electrodes can provide a better selectivity when compared to the commonly used graphite electrodes. In addition, the oxidation/reduction products and the morphological changes of the solid particles resulting from the solid-state electrochemical processes can be characterized by auxiliary techniques such as scanning electrochemical microscopy and or scanning electron microscopy, providing relevant information on the electrochemical mechanisms of the studied drugs, which, despite their importance, are little discussed in the literature.
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