Metabolomic study of Brazilian plants used in the treatment of chronic diseases

• Grant number: 19/18673-8
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date: January 20, 2020
• End date: October 19, 2020
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Wagner Vilegas
• Grantee: Ana Caroline Zanatta Silva
• Supervisor: Ruangelie Edrada-Ebel
• Host Institution: Instituto de Biociências (IB-CLP). Universidade Estadual Paulista (UNESP). Campus Experimental do Litoral Paulista. São Vicente , SP, Brazil
• Institution abroad: University of Strathclyde, Scotland
• Associated to the scholarship: 16/21044-4 - Standardization of phytomedicines for the treatment of chronic diseases, BP.DR

Abstract

Peptic ulcer is a common disease found to be prevalent worldwide, and which affects a large number of people. Continued use of drugs in anti-ulcer therapy often produces several side effects. The present project has been designed as part of the efforts to develop an efficient treatment capable of ensuring essentially more effective pharmacological effects to patients who are faced with the need to continue using drugs for therapeutic purposes. The project aims to employ the metabolomic approach as a necessary tool for quality control and authentication of Byrsonima intermedia, Serjania marginata and Terminalia catappa extracts/phytopreparations, which will be used for the treatment of chronic diseases. With regard to the execution of the project, the quality control of the species investigated will be evaluated using advanced analytical techniques [UHPLC-DAD-(ESI)-HRMS and RMN], multivariate statistical analyses, and the integration of orthogonal biological approaches; these techniques will be used to assess a set of chemical compositions and environmental variables, and to better understand the effects of metabolites with anti-inflammatory activity in B. Intermedia, S. marginata and T. catappa plant extracts. The metabolomic approach is employed aiming at ensuring a more selective, fast and efficient analysis of the chemical compositions of B. intermedia, S. marginata and T. catappa species. (AU)

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

ZANATTA, ANA C.; VILEGAS, WAGNER; EDRADA-EBEL, RUANGELIE. UHPLC-(ESI)-HRMS and NMR-Based Metabolomics Approach to Access the Seasonality of Byrsonima intermedia and Serjania marginata From Brazilian Cerrado Flora Diversity. FRONTIERS IN CHEMISTRY, v. 9, JUL 6 2021. (16/21044-4, 19/18673-8)

ZANATTA, ANA C.; BORGES, MAIARA S.; MANNOCHIO-RUSSO, HELENA; HEREDIA-VIEIRA, SILVIA CRISTINA; DOS SANTOS, LOURDES CAMPANER; RINALDO, DANIEL; VILEGAS, WAGNER. Green chromatography as a novel alternative for the quality control of Serjania marginata Casar. Leaves. Microchemical Journal, v. 181, p. 12-pg., 2022-06-15. (14/50926-0, 16/21044-4, 16/08179-8, 19/18673-8)

FERNANDEZ-BOBEY, ANTONIO; DIAS, NATHALIA BAPTISTA; VIEIRA, NATALIA CAROLINA; ZANATTA, ANA C.; DE SOUZA, BIBIANA MONSON; DE PAULA-SOUZA, JULIANA; DA SILVA BOLZANI, VANDERLAN; PALMA, MARIO SERGIO. Violaceae: chemical constituents, traditional use and pharmacology. PHYTOCHEMISTRY REVIEWS, v. N/A, p. 81-pg., 2023-07-19. (19/18673-8, 13/07600-3, 16/21044-4, 19/26550-3, 16/16212-5, 14/50926-0)

ZANATTA, ANA C.; VIEIRA, NATALIA CAROLINA; DANTAS-MEDEIROS, RENATO; VILEGAS, WAGNER; EDRADA-EBEL, RUANGELIE. Understanding the Seasonal Effect of Metabolite Production in Terminalia catappa L. Leaves through a Concatenated MS- and NMR-Based Metabolomics Approach. METABOLITES, v. 13, n. 3, p. 20-pg., 2023-03-01. (19/18673-8, 16/21044-4)