| Grant number: | 19/23343-7 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | December 01, 2019 |
| End date: | January 31, 2023 |
| Field of knowledge: | Interdisciplinary Subjects |
| Principal Investigator: | Roberto Marcondes Cesar Junior |
| Grantee: | Daniel Santa Cruz Damineli |
| Host Institution: | Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil |
| Associated research grant: | 15/22308-2 - Intermediate representations in Computational Science for knowledge discovery, AP.TEM |
Abstract Description of the project: The Laboratory of Pediatric Genomics, Pediatrics Department, Faculdade de Medicina da Universidade de São Paulo (FMUSP), offers a postdoctoral position for scientists interested in temporal analysis of gene expression. The project focus on the analysis of time-series gene expression data in order to get a better understanding of biological systems dynamics focusing the health-disease transition processes. The postdoctoral fellow will specifically work in two projects: i) development of mathematical and computational models for investigating hippocampal gene expression alterations in rats submitted to hyperthermic insult (an animal model for epilepsy induced by febrile insult); ii) temporal study of gene expression alterations in human enterocytes during in vitro interaction with enteropathogenic bacteria. The PD researcher will be responsible to propose and implement models for intermediate network representations from raw data. The research will take into account various data sources, inconsistencies and uncertainties in them. The proposed approach will combine different techniques for analysis and modelling (combinatorics, optimisation, and statistical methods) and different sources of experimental data (genomics, transcriptomics, proteomics, metabolomics) to deal with the inaccuracies. Of particular interest is how to incorporate machine learning methods to this approach. (AU) | |
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