| Grant number: | 20/05816-2 |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| Start date: | July 01, 2020 |
| End date: | June 30, 2023 |
| Field of knowledge: | Biological Sciences - Biochemistry - Chemistry of Macromolecules |
| Principal Investigator: | Leonardo Fernandes Fraceto |
| Grantee: | Mariana Guilger Casagrande |
| Host Institution: | Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil |
| Associated research grant: | 17/21004-5 - Agriculture, micro/nanotechnology and environment: from evaluation of the mechanisms of action to studies of transport and toxicity, AP.TEM |
Abstract Currently, metallic nanoparticles represent an emerging and widely studied technology due to their potential benefits. The biogenic synthesis of nanoparticles has some advantages over other types of synthesis because it is an environmentally friendly method in which extracts of organisms such as plants, bacteria and fungi are used as reducers and stabilizers, instead of chemicals with potential toxicity. In addition, this method gives rise to nanoparticles with better colloidal properties, size control and biocompatibility, which have a coating that can enhance biological activity. Among the biological reducers that act in the synthesis of nanoparticles, fungi have advantages, as they secrete a large number of enzymes, have a fast-mycelial growth and are easy to manipulate. In this sense, the proposal of this project involves the study of the covering of biogenic nanoparticles that use the fungi Trichoderma harzianum and Beauveria bassiana as reducing agents, these organisms, the focus of the thematic project in question. As it is known, the capping present in these nanoparticles has unique characteristics and give these particularities that influence their activity and toxicity. In this way, knowing its composition and how it is formed, its activity and what influence it exerts on nanoparticles is of great importance for us to be able to advance in the theme. Therefore, the challenges are facing a better understanding of the composition of this capping and for that it is necessary to use research techniques that contribute to the understanding of the correlation between the composition of the cover in different synthesis routes, as well as its importance for the nanoparticle stability, biological activity and toxicity. (AU) | |
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