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Study of the capping of biogenic nanoparticles and their correlation with toxicity and activity in the control of phytopathogens

Grant number: 20/05816-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2020
Effective date (End): June 30, 2022
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal researcher:Leonardo Fernandes Fraceto
Grantee:Mariana Guilger Casagrande
Home Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil
Associated research grant:17/21004-5 - Agriculture, micro/nanotechnology and environment: from evaluation of the mechanisms of action to studies of transport and toxicity, AP.TEM

Abstract

Currently, metallic nanoparticles represent an emerging and widely studied technology due to their potential benefits. The biogenic synthesis of nanoparticles has some advantages over other types of synthesis because it is an environmentally friendly method in which extracts of organisms such as plants, bacteria and fungi are used as reducers and stabilizers, instead of chemicals with potential toxicity. In addition, this method gives rise to nanoparticles with better colloidal properties, size control and biocompatibility, which have a coating that can enhance biological activity. Among the biological reducers that act in the synthesis of nanoparticles, fungi have advantages, as they secrete a large number of enzymes, have a fast-mycelial growth and are easy to manipulate. In this sense, the proposal of this project involves the study of the covering of biogenic nanoparticles that use the fungi Trichoderma harzianum and Beauveria bassiana as reducing agents, these organisms, the focus of the thematic project in question. As it is known, the capping present in these nanoparticles has unique characteristics and give these particularities that influence their activity and toxicity. In this way, knowing its composition and how it is formed, its activity and what influence it exerts on nanoparticles is of great importance for us to be able to advance in the theme. Therefore, the challenges are facing a better understanding of the composition of this capping and for that it is necessary to use research techniques that contribute to the understanding of the correlation between the composition of the cover in different synthesis routes, as well as its importance for the nanoparticle stability, biological activity and toxicity. (AU)

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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MONTEIRO, RENATA APARECIDA; CAMARA, MARCELA CANDIDO; DE OLIVEIRA, JHONES LUIZ; RAMOS CAMPOS, ESTEFANIA VANGELIE; CARVALHO, LUCAS BRAGANCA; DE FREITAS PROENCA, PATRICIA LUIZA; GUILGER-CASAGRANDE, MARIANA; LIMA, RENATA; DO NASCIMENTO, JOACIR; GONCALVES, KELLY CRISTINA; POLANCZYK, RICARDO ANTONIO; FRACETO, LEONARDO FERNANDES. Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture. JOURNAL OF HAZARDOUS MATERIALS, v. 417, SEP 5 2021. Web of Science Citations: 0.
GUILGER-CASAGRANDE, MARIANA; DE BARROS, CECILIA T.; ANTUNES, VITORIA A. N.; DE ARAUJO, DANIELE R.; LIMA, RENATA. Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, v. 11, MAR 15 2021. Web of Science Citations: 0.
GUILGER-CASAGRANDE, MARIANA; GERMANO-COSTA, TAIS; BILESKY-JOSE, NATALIA; PASQUOTO-STIGLIANI, TATIANE; CARVALHO, LUCAS; FRACETO, LEONARDO F.; DE LIMA, RENATA. Influence of the capping of biogenic silver nanoparticles on their toxicity and mechanism of action towards Sclerotinia scierotiorum. JOURNAL OF NANOBIOTECHNOLOGY, v. 19, n. 1 FEB 24 2021. Web of Science Citations: 0.
CAMPOS, ESTEFANIA V. R.; PEREIRA, ANDERSON E. S.; DE OLIVEIRA, JHONES LUIZ; CARVALHO, LUCAS BRAGANCA; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. JOURNAL OF NANOBIOTECHNOLOGY, v. 18, n. 1 SEP 5 2020. Web of Science Citations: 39.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.