Agriculture, micro/nanotechnology and environment: from evaluation of the mechanisms of action to studies of transport and toxicity

• Grant number: 17/21004-5
• Support type: Research Projects - Thematic Grants
• Duration: September 01, 2018 - August 31, 2023
• Field of knowledge: Biological Sciences - Biochemistry - Chemistry of Macromolecules
• Principal researcher: Leonardo Fernandes Fraceto
• Grantee: Leonardo Fernandes Fraceto
• Home Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil
• Pesquisadores principais: Ricardo Antonio Polanczyk
• Assoc. researchers: Alejandra Bravo ; Carlos Alberto Pérez ; Claudia Bueno dos Reis Martinez ; Claudio Martin Jonsson ; Daiana Silva de Ávila ; Gerson Araujo de Medeiros ; Halley Caixeta de Oliveira ; Juliana Lischka Sampaio Mayer ; Luciana de Matos Alves Pinto ; Marcelo Bispo de Jesus ; Renata de Lima ; Renato Grillo ; Ricardo Antonio Polanczyk ; Vera Lucia Scherholz Salgado de Castro
• Associated scholarship(s): 21/12643-0 - Association of biogenic silica nanoparticles obtained from rice husk as a strategy to increase the bioavailability of Beauveria bassiana for pest control, BP.PD; 20/12769-0 - Gold nanoparticles encapsulated in nanocarriers of pesticide as a potential label for understanding its fate in plants, BP.IC; 20/05816-2 - Study of the capping of biogenic nanoparticles and their correlation with toxicity and activity in the control of phytopathogens, BP.PD; + associated scholarships 19/22360-5 - Encapsulation of Beauveria bassiana (Hypocreales: Cordycipitaceae) in polymeric microparticles by spray-drying technique to control Tetranychus urticae (Acari: Tetranichydae), BP.IC; 18/21142-1 - Encapsulation of Bacillus thuringiensis (Bacillales: Bacillaceae) in polymeric microparticles and association with nanoencapsulated chemical agent: evaluation of biological activity and mechanisms of action, BP.PD; 19/14829-3 - Study of the interaction of pesticides and nanopesticides with soil, BP.IC; 19/12257-2 - Evaluation of environmental security of nanoatrazine and azadiractin, BP.TT; 18/23608-8 - Development of labelled nanopesticides aiming studies of mechanism of action and toxicity, BP.PD - associated scholarships

Abstract

Modern agriculture can no longer be based on the intensive use of agricultural inputs that affect the environment. In this way, researchers, farmers and consumers must evolve towards ecologically and economically satisfactory production, in addition, new technologies must be adopted in order to optimize productivity while maintaining sustainable environment base. In this sense, there is a search for more sustainable practices to meet the premises of integrated pest and disease management in agriculture. Based on this scenario, this thematic proposal aims to elucidate the mechanisms of action and toxicity of systems based on micro and nanotechnology for pest control in agriculture, as well as to study the fate of these systems in the environment, with the intention of producing scientific knowledge necessary for understanding of the phenomena and processes that govern its biological activity. It should be emphasized that the present project has a strong multiplier character in the area of micro/nanotechnology in the scientific environment, due to the large number of research groups and institutions involved with the topic. In addition to the proposed scientific impact, we emphasize that the proposal, due to the participation of researchers, teachers, undergraduate and graduate students, will certainly have a great impact on the dissemination and improvement of the methods used, aiming at the use of more sustainable practices for pest control and diseases in agriculture. (AU)

Scientific publications

(37)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SARAIVA, NARIANI ROCHA; RONCATO, JULIANA FOLETTO FREDO; PASCOLI, MONICA; MACEDO E SOUSA, JOAO MARCOS FONSECA; WINDBERG, JR., LUIZ FELIPE; ROSSATTO, FERNANDA CRISTINA POSSAMAI; SOARES, JEFFERSON DE JESUS; DENARDIN, ELTON LUIS GASPAROTTO; PUNTEL, ROBSON LUIZ; ZIMMER, KARINE RIGON; FRACETO, LEONARDO FERNANDES; AVILA, DAIANA SILVA. Clove oil-loaded zein nanoparticles as potential bioinsecticide agent with low toxicity. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 24, DEC 2021. Web of Science Citations: 0.

WU, JUAN; ZHAI, YUJIA; MONIKH, FAZEL ABDOLAHPUR; ARENAS-LAGO, DANIEL; GRILLO, RENATO; VIJVER, MARTINA G.; PEIJNENBURG, WILLIE J. G. M. The Differences between the Effects of a Nanoformulation and a Conventional Form of Atrazine to Lettuce: Physiological Responses, Defense Mechanisms, and Nutrient Displacement. Journal of Agricultural and Food Chemistry, v. 69, n. 42, p. 12527-12540, OCT 27 2021. Web of Science Citations: 1.

BAIGORRIA, ESTEFANIA; FRACETO, LEONARDO F. Biopolymer-Nanocomposite Hybrid Materials as Potential Strategy to Remove Pesticides in Water: Occurrence and Perspectives. ADVANCED SUSTAINABLE SYSTEMS, OCT 2021. Web of Science Citations: 0.

TAKESHITA, VANESSA; DE SOUSA, BRUNO TEIXEIRA; PREISLER, ANA CRISTINA; CARVALHO, LUCAS BRAGANCA; SANTO PEREIRA, ANDERSON DO ESPIRITO; TORNISIELO, VALDEMAR LUIZ; DALAZEN, GILIARDI; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES. Foliar absorption and field herbicidal studies of atrazine-loaded polymeric nanoparticles. JOURNAL OF HAZARDOUS MATERIALS, v. 418, SEP 15 2021. Web of Science Citations: 0.

MONTEIRO, RENATA APARECIDA; CAMARA, MARCELA CANDIDO; DE OLIVEIRA, JHONES LUIZ; RAMOS CAMPOS, ESTEFANIA VANGELIE; CARVALHO, LUCAS BRAGANCA; DE FREITAS PROENCA, PATRICIA LUIZA; GUILGER-CASAGRANDE, MARIANA; LIMA, RENATA; DO NASCIMENTO, JOACIR; GONCALVES, KELLY CRISTINA; POLANCZYK, RICARDO ANTONIO; FRACETO, LEONARDO FERNANDES. Zein based-nanoparticles loaded botanical pesticides in pest control: An enzyme stimuli-responsive approach aiming sustainable agriculture. JOURNAL OF HAZARDOUS MATERIALS, v. 417, SEP 5 2021. Web of Science Citations: 2.

LUIS, ANGELICA I. S.; CAMPOS, ESTEFANIA V. R.; OLIVEIRA, JHONES L.; VALLIM, JOSE HENRIQUE; PROENCA, PATRICIA L. F.; CASTANHA, RODRIGO F.; DE CASTRO, VERA L. S. S.; FRACETO, LEONARDO F. Ecotoxicity evaluation of polymeric nanoparticles loaded with ascorbic acid for fish nutrition in aquaculture. JOURNAL OF NANOBIOTECHNOLOGY, v. 19, n. 1 MAY 31 2021. Web of Science Citations: 0.

PONTES, MONTCHARLES S.; ANTUNES, DEBORA R.; OLIVEIRA, IVAN P.; FORINI, MARIANA M. L.; SANTOS, JAQUELINE S.; ARRUDA, GILBERTO J.; CAIRES, ANDERSON R. L.; SANTIAGO, ETENALDO F.; GRILLO, RENATO. Chitosan/tripolyphosphate nanoformulation carrying paraquat: insights on its enhanced herbicidal activity. ENVIRONMENTAL SCIENCE-NANO, v. 8, n. 5, p. 1336-1351, MAY 1 2021. Web of Science Citations: 1.

DE ALBUQUERQUE, FELICIA PEREIRA; DE OLIVEIRA, JHONES LUIZ; DOS SANTOS MACHADO, LEILA; RICHARDI, VINICIUS SOBRINHO; DA SILVA, MARIO ANTONIO NAVARRO; POMPEO, MARCELO LUIZ MARTINS; FRACETO, LEONARDO FERNANDES; CARLOS, VIVIANE MOSCHINI. Use of nontarget organism Chironomus sancticaroli to study the toxic effects of nanoatrazine. ECOTOXICOLOGY, v. 30, n. 4, p. 733-750, MAY 2021. Web of Science Citations: 0.

DE OLIVEIRA, JHONES L.; FRACETO, LEONARDO FERNANDES; BRAVO, ALEJANDRA; POLANCZYK, RICARDO ANTONIO. Encapsulation Strategies for Bacillus thuringiensis: From Now to the Future. Journal of Agricultural and Food Chemistry, v. 69, n. 16, p. 4564-4577, APR 28 2021. Web of Science Citations: 0.

DE ALBUQUERQUE, FELICIA PEREIRA; DE OLIVEIRA, JHONES LUIZ; DOS SANTOS MACHADO, LEILA; RICHARDI, VINICIUS SOBRINHO; DA SILVA, MARIO ANTONIO NAVARRO; POMPEO, MARCELO LUIZ MARTINS; FRACETO, LEONARDO FERNANDES; CARLOS, VIVIANE MOSCHINI. Use of nontarget organism Chironomus sancticaroli to study the toxic effects of nanoatrazine. ECOTOXICOLOGY, v. 30, n. 4 APR 2021. Web of Science Citations: 0.

GRILLO, RENATO; MATTOS, BRUNO D.; ANTUNES, DEBORA R.; FORINI, MARIANA M. L.; MONIKH, FAZEL A.; ROJAS, ORLANDO J. Foliage adhesion and interactions with particulate delivery systems for plant nanobionics and intelligent agriculture. NANO TODAY, v. 37, APR 2021. Web of Science Citations: 4.

PONTES, MONTCHARLES S.; ANTUNES, DEBORA R.; OLIVEIRA, IVAN P.; FORINI, MARIANA M. L.; SANTOS, JAQUELINE S.; ARRUDA, GILBERTO J.; CAIRES, ANDERSON R. L.; SANTIAGO, ETENALDO F.; GRILLO, RENATO. Chitosan/tripolyphosphate nanoformulation carrying paraquat: insights on its enhanced herbicidal activity. ENVIRONMENTAL SCIENCE-NANO, v. 8, n. 5 MAR 2021. Web of Science Citations: 0.

GUILGER-CASAGRANDE, MARIANA; GERMANO-COSTA, TAIS; BILESKY-JOSE, NATALIA; PASQUOTO-STIGLIANI, TATIANE; CARVALHO, LUCAS; FRACETO, LEONARDO F.; DE LIMA, RENATA. Influence of the capping of biogenic silver nanoparticles on their toxicity and mechanism of action towards Sclerotinia scierotiorum. JOURNAL OF NANOBIOTECHNOLOGY, v. 19, n. 1 FEB 24 2021. Web of Science Citations: 0.

GRILLO, RENATO; FRACETO, LEONARDO F.; AMORIM, MONICA J. B.; SCOTT-FORDSMAND, JANECK JAMES; SCHOONJANS, REINHILDE; CHAUDHRY, QASIM. Ecotoxicological and regulatory aspects of environmental sustainability of nanopesticides. JOURNAL OF HAZARDOUS MATERIALS, v. 404, n. A FEB 15 2021. Web of Science Citations: 21.

BILESKY-JOSE, NATALIA; MARUYAMA, CINTIA; GERMANO-COSTA, TAIS; CAMPOS, ESTEFANIA; CARVALHO, LUCAS; GRILLO, RENATO; FRACETO, LEONARDO FERNANDES; DE LIMA, RENATA. Biogenic alpha-Fe2O3 Nanoparticles Enhance the Biological Activity of Trichoderma against the Plant Pathogen Sclerotinia sclerotiorum. ACS SUSTAINABLE CHEMISTRY & ENGINEERING, v. 9, n. 4, p. 1669-1683, FEB 1 2021. Web of Science Citations: 4.

SANTO PEREIRA, ANDERSON DO ESPIRITO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES; SANTAELLA, CATHERINE. Nanotechnology Potential in Seed Priming for Sustainable Agriculture. NANOMATERIALS, v. 11, n. 2 FEB 2021. Web of Science Citations: 0.

ZHAI, YUJIA; ABDOLAHPUR MONIKH, FAZEL; WU, JUAN; GRILLO, RENATO; ARENAS-LAGO, DANIEL; DARBHA, GOPALA KRISHNA; VIJVER, MARTINA G.; PEIJNENBURG, WILLIE J. G. M. Interaction between a nano-formulation of atrazine and rhizosphere bacterial communities: atrazine degradation and bacterial community alterations. ENVIRONMENTAL SCIENCE-NANO, v. 7, n. 11, p. 3372-3384, NOV 1 2020. Web of Science Citations: 0.

FORINI, MARIANA M. L.; ANTUNES, DEBORA R.; CAVALCANTE, LUIZ A. F.; PONTES, MONTCHARLES S.; BISCALCHIM, ERICA R.; SANCHES, ALEX O.; SANTIAGO, ETENALDO F.; FRACETO, LEONARDO F.; GRILLO, RENATO. Fabrication and Characterization of a Novel Herbicide Delivery System with Magnetic Collectability and Its Phytotoxic Effect on Photosystem II of Aquatic Macrophyte. Journal of Agricultural and Food Chemistry, v. 68, n. 40, p. 11105-11113, OCT 7 2020. Web of Science Citations: 0.

CAMPOS, ESTEFANIA V. R.; PEREIRA, ANDERSON E. S.; DE OLIVEIRA, JHONES LUIZ; CARVALHO, LUCAS BRAGANCA; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. JOURNAL OF NANOBIOTECHNOLOGY, v. 18, n. 1 SEP 5 2020. Web of Science Citations: 39.

MUJTABA, MUHAMMAD; KHAWAR, KHALID MAHMOOD; CAMARA, MARCELA CANDIDO; CARVALHO, LUCAS BRAGANCA; FRACETO, LEONARDO FERNANDES; MORSI, RANIA E.; ELSABEE, MAHER Z.; KAYA, MURAT; LABIDI, JALEL; ULLAH, HIDAYAT; WANG, DEPENG. Chitosan-based delivery systems for plants: A brief overview of recent advances and future directions. International Journal of Biological Macromolecules, v. 154, p. 683-697, JUL 1 2020. Web of Science Citations: 1.

LUIS, ANGELICA I. S.; CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; GUILGER-CASAGRANDE, MARIANA; DE LIMA, RENATA; CASTANHA, RODRIGO F.; DE CASTRO, VERA L. S. S.; FRACETO, LEONARDO F. Zein Nanoparticles Impregnated with Eugenol and Garlic Essential Oils for Treating Fish Pathogens. ACS OMEGA, v. 5, n. 25, p. 15557-15566, JUN 30 2020. Web of Science Citations: 0.

DA SILVA, NATARA D. G.; CARNEIRO, CRISTIANE E. A.; CAMPOS, ESTEFANIA V. R.; DE OLIVEIRA, JHONES L.; RISSO, WAGNER E.; FRACETO, LEONARDO F.; ZAIA, DIMAS A. M.; MARTINEZ, CLAUDIA B. R. Interference of goethite in the effects of glyphosate and Roundup (R) on ZFL cell line. TOXICOLOGY IN VITRO, v. 65, JUN 2020. Web of Science Citations: 0.

BARTOLUCCI, CECILIA; ANTONACCI, AMINA; ARDUINI, FABIANA; MOSCONE, DANILA; FRACETO, LEONARDO; CAMPOS, ESTEFANIA; ATTAALLAH, RAOUIA; AMINE, AZIZ; ZANARDI, CHIARA; CUBILLANA-AGUILERA, LAURA M.; PALACIOS SANTANDER, JOSE MARIA; SCOGNAMIGLIO, VIVIANA. Green nanomaterials fostering agrifood sustainability. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 125, APR 2020. Web of Science Citations: 0.

MARUYAMA, CINTIA RODRIGUES; BILESKY-JOSE, NATALIA; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. Encapsulation of Trichoderma harzianum Preserves Enzymatic Activity and Enhances the Potential for Biological Control. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, v. 8, MAR 25 2020. Web of Science Citations: 0.

TESSER, MARIA EDUARDA; DE PAULA, ANGELICA ALVES; RISSO, WAGNER EZEQUIEL; MONTEIRO, RENATA APARECIDA; SANTO PEREIRA, ANDERSON DO ESPIRITO; FRACETO, LEONARDO FERNANDES; DOS REIS MARTINEZ, CLAUDIA BUENO. Sublethal effects of waterborne copper and copper nanoparticles on the freshwater Neotropical teleost Prochilodus lineatus: A comparative approach. Science of The Total Environment, v. 704, FEB 20 2020. Web of Science Citations: 0.

DE ALBUQUERQUE, FELICIA PEREIRA; DE OLIVEIRA, JHONES LUIZ; MOSCHINI-CARLOS, VIVIANE; FRACETO, LEONARDO FERNANDES. An overview of the potential impacts of atrazine in aquatic environments: Perspectives for tailored solutions based on nanotechnology. Science of The Total Environment, v. 700, JAN 15 2020. Web of Science Citations: 0.

DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; CAMARA, MARCELA CANDIDO; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES DE MATOS, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; GONCALVES, KELLY CRISTINA; DO NASCIMENTO, JOACIR; POLANCZYK, RICARDO ANTONIO; DE ARAUJO, DANIELE RIBEIRO; FRACETO, LEONARDO FERNANDES. Hydrogels Containing Botanical Repellents Encapsulated in Zein Nanoparticles for Crop Protection. ACS APPLIED NANO MATERIALS, v. 3, n. 1, p. 207-217, JAN 2020. Web of Science Citations: 0.

PASCOLI, MONICA; DE ALBUQUERQUE, FELICIA PEREIRA; CALZAVARA, ANDERSON KIKUCHI; TINOCO-NUNES, BRUNO; CRUZ OLIVEIRA, WANDERSON HENRIQUE; GONCALVES, KELLY CRISTINA; POLANCZYK, RICARDO ANTONIO; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES DE MATOSS, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; OLIVEIRA, HALLEY CAIXETA; SOUZA-NETO, JAYME A.; DE LIMA, RENATA; FRACETO, LEONARDO FERNANDES. The potential of nanobiopesticide based on zein nanoparticles and neem oil for enhanced control of agricultural pests. JOURNAL OF PEST SCIENCE, v. 93, n. 2 JAN 2020. Web of Science Citations: 4.

PREISLER, ANA C.; PEREIRA, ANDERSON E. S.; CAMPOS, ESTEFANIA V. R.; DALAZEN, GILIARDI; FRACETO, LEONARDO F.; OLIVEIRA, HALLEY C. Atrazine nanoencapsulation improves pre-emergence herbicidal activity against Bidens pilosa without enhancing long-term residual effect on Glycine max. Pest Management Science, v. 76, n. 1, p. 141-149, JAN 2020. Web of Science Citations: 2.

OLIVEIRA, CRISTIANE R.; DOMINGUES, CAIO E. C.; DE MELO, NATHALIE F. S.; ROAT, THAISA C.; MALASPINA, OSMAR; JONES-COSTA, MONICA; SILVA-ZACARIN, ELAINE C. M.; FRACETO, LEONARDO F. Nanopesticide based on botanical insecticide pyrethrum and its potential effects on honeybees. Chemosphere, v. 236, DEC 2019. Web of Science Citations: 0.

GUILGER-CASAGRANDE, MARIANA; GERMANO-COSTA, TAIS; PASQUOTO-STIGLIANI, TATIANE; FRACETO, LEONARDO FERNANDES; DE LIMA, RENATA. Biosynthesis of silver nanoparticles employing Trichoderma harzianum with enzymatic stimulation for the control of Sclerotinia sclerotiorum. SCIENTIFIC REPORTS, v. 9, OCT 4 2019. Web of Science Citations: 0.

OLIVEIRA, C. R.; GARCIA, T. D.; FRANCO-BELUSSI, L.; SALLA, R. F.; SOUZA, B. F. S.; DE MELO, N. F. S.; IRAZUSTA, S. P.; JONES-COSTA, M.; SILVA-ZACARIN, E. C. M.; FRACETO, L. F. Pyrethrum extract encapsulated in nanoparticles: Toxicity studies based on genotoxic and hematological effects in bullfrog tadpoles. Environmental Pollution, v. 253, p. 1009-1020, OCT 2019. Web of Science Citations: 0.

PASCOLI, MONICA; JACQUES, MAURICIO T.; AGARRAYUA, DANIELLE A.; AVILA, DAIANA S.; LIMA, RENATA; FRACETO, LEONARDO F. Neem oil based nanopesticide as an environmentally-friendly formulation for applications in sustainable agriculture: An ecotoxicological perspective. Science of The Total Environment, v. 677, p. 57-67, AUG 10 2019. Web of Science Citations: 3.

DE OLIVEIRA, JHONES L.; CAMPOS, ESTEFANIA V. R.; GERMANO-COSTA, TAIS; LIMA, RENATA; DELLA VECHIA, JAQUELINE FRANCIOSI; SOARES, SIDNEIA TEREZINHA; DE ANDRADE, DANIEL JUNIOR; GONCALVES, KELLY CRISTINA; DO NASCIMENTO, JOACIR; POLANCZYK, RICARDO ANTONIO; FRACETO, LEONARDO FERNANDES. Association of zein nanoparticles with botanical compounds for effective pest control systems. Pest Management Science, v. 75, n. 7, p. 1855-1865, JUL 2019. Web of Science Citations: 5.

GOMES, SUSANA I. L.; SCOTT-FORDSMAND, JANECK J.; CAMPOS, ESTEFANIA V. R.; GRILLO, RENATO; FRACETO, LEONARDO F.; AMORIM, MONICA J. B. On the safety of nanoformulations to non-target soil invertebrates - an atrazine case study. ENVIRONMENTAL SCIENCE-NANO, v. 6, n. 6, p. 1950-1958, JUN 1 2019. Web of Science Citations: 1.

SANTO PEREIRA, ANDERSON DO ESPIRITO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES. Polymeric nanoparticles as an alternative for application of gibberellic acid in sustainable agriculture: a field study. SCIENTIFIC REPORTS, v. 9, MAY 9 2019. Web of Science Citations: 2.

BOMBO, ALINE BERTOLOSI; SANTO PEREIRA, ANDERSON ESPIRITO; LUSA, MAKELI GARIBOTTI; OLIVEIRA, ELIANA DE MEDEIROS; DE OLIVEIRA, JHONES LUIS; RAMOS CAMPOS, ESTEFANIA VANGELIE; DE JESUS, MARCELO BISPO; OLIVEIRA, HALLEY CAIXETA; FRACETO, LEONARDO FERNANDES; SAMPAIO MAYER, JULIANA LISCHKA. A Mechanistic View of Interactions of a Nanoherbicide with Target Organism. Journal of Agricultural and Food Chemistry, v. 67, n. 16, p. 4453-4462, APR 24 2019. Web of Science Citations: 2.