Evaluation of NOX-1 expression as an indicator of DDVP influence on oxidative stress in prostate of rats submitted to chemical induction by MNU

• Grant number: 19/20679-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: February 01, 2021
• End date: December 31, 2022
• Field of knowledge: Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology
• Principal Investigator: Sérgio Pereira
• Grantee: Eleonora Malavolta Pizzo
• Host Institution: Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil

Abstract

Prostate cancer affects much of the world's male human population. Different factors may lead to the occurrence of this neoplasm through prostatic lesions that change prostate characteristics and functions, such as physical and urinary trauma, infectious agents, eating habits, genetic mutations and hormonal variations. Organophosphate pesticides are widely used in agriculture because of their efficiency in production, but they pose a great risk to the environment and the health of many organisms. Dichlorvos (DDVP) is an organophosphate pesticide that has mutagenic potential and can act as an endocrine disrupter capable of changing endocrine homeostasis via androgen receptors (RA) or via estrogen receptors (ERs), causing several endocrine and reproductive changes, such as oxidative stress and prostate cancer. Therefore, the study of reactive oxygen species (ROS) is essential to understand the mechanisms of oxidative stress in the development of prostatic lesions. Thus, the present work aims to analyze the expression of reactive oxygen species (ROS) in the prostate of rats submitted to chemical induction by MNU associated with dichlorvos pesticide (DDVP).