| Grant number: | 22/04198-9 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | July 01, 2022 |
| End date: | June 30, 2023 |
| Field of knowledge: | Health Sciences - Medicine - Pathological Anatomy and Clinical Pathology |
| Principal Investigator: | Sergio Pereira |
| Grantee: | Laura Ribeiro da Silva |
| Host Institution: | Faculdade de Ciências (FC). Universidade Estadual Paulista (UNESP). Campus de Bauru. Bauru , SP, Brazil |
Abstract Organophosphate pesticides are much utilized in agriculture for insect control, however, they are toxic for many organisms. In human beings, for example, can function as endocrine disruptors, as mutagenic agents and carcinogens. Among these compounds is the dichlorvos (DDVP), a pesticide very utilized in pest control on account of it's efficiency and low cost, nonetheless, is potentially capable of promoting a alteration of lipid metabolism that is associated also to the development of cancer, it can be explained by the fact that tumoral cells can utilize fatty acids to compose it's membranes in the making. Bearing in mind the relation between dichlorvos, prostatic carcinogenesis, lipogenesis and it's molecular markers, the present project's objective is to evaluate the influence of pesticide DDVP on lipid metabolism's proteins (SREBP and SCAP) on rats prostates, associated or not to the chemical induction by the carcinogen N-methyl-N-nitrosourea (MNU). For this, it will be use 32 male rats of the lineage Fischer 344, with the age of 90 days, which will be separated into four experimental groups: Control, DDVP, MNU, MNU+DDVP. After the euthanasia, the prostate ventral lobe of each animal will be sent to immunohistochemic analises of the SREBP and SCAP proteins. | |
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