Predicting neurodevelopment by stressors exposures through statistical models: an integrative approach

• Grant number: 21/00485-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: April 01, 2021
• End date: March 31, 2025
• Field of knowledge: Interdisciplinary Subjects
• Principal Investigator: David Corrêa Martins Junior
• Grantee: Caio Isaias da Silva Braga
• Host Institution: Centro de Matemática, Computação e Cognição (CMCC). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
• Associated research grant: 18/18560-6 - Data integration to identify biological markers of neurodevelopmental disorders, AP.TEM
• Associated scholarship(s): 23/01343-0 - Investigating dynamics on stress effect over sncRNA expression on human sperm through bioinformatic modeling, BE.EP.DD

Abstract

Prenatal adverse environments alters normal brain development and have consequences for brain structure and function throughout life, increasing the risk of developing mental disorders. Placenta is the organ responsible for mother and fetus mediation. Placental imprinted genes, for example, play an important role in neurodevelopmental disorders vulnerability. This project aims to analyze data from module I, project 2, seeking to measure the association between the prenatal stress exposure construct and anthropometric measures of the newborn. Moreover, we aim to study whether the placental mediation in this association is different between genders. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

EUCLYDES, VERONICA; BRAGA, CAIO I. S.; GOUVEIA, GISELE; MARTINEZ, RAQUEL C. R.; CAMILO, CAROLINE; SIMOES, SERGIO N.; MARTINS-JR, DAVID C.; FRACOLLI, LISLAINE; ARGEU, ADRIANA; FERRARO, ALEXANDRE; et al. Maternal immune response during pregnancy and neurodevelopmental outcomes: A longitudinal approach. BRAIN, BEHAVIOR, & IMMUNITY - HEALTH, v. 40, p. 11-pg., 2024-08-05. (18/18560-6, 20/16376-3, 23/01343-0, 16/22455-8, 18/21934-5, 20/15590-1, 21/00485-0)