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Evaluation of the effects of treatment with methylphenidate compared with parental training in preschool children with ADHD on the path of cognitive, social, emotional and psychopathological development

Grant number: 21/08540-0
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2021
Effective date (End): March 31, 2023
Field of knowledge:Health Sciences - Medicine - Psychiatry
Principal researcher:Guilherme Vanoni Polanczyk
Grantee:Luis Carlos Farhat
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/22455-8 - Early childhood interventions and trajectories of cognitive, social and emotional development, AP.TEM


The present work plan has two studies: (I) evaluation of the effects of treatment with methylphenidate in comparison with parental training in preschool children with Attention Deficit Hyperactivity Disorder (ADHD) on the trajectories of cognitive, social and emotional development and on general psychopathology throughout childhood; (II) evaluation of the moderating effect of baseline characteristics of preschool children on the path of development and psychopathology throughout childhood. For study I, the psychopathological and socioemotional profile measured over time (baseline, 8 weeks, 1, 2 and 3 years) adopted using the Child Behavior Checklist (CBCL), Strength and Difficulties Questionnaire (SDQ), The Child Behavior Questionnaire (CBQ), SNAP-IV Teacher and Parental Rating Scale vary depending on (DV) continuous repeated measures. Membership in the methylphenidate group or parental training will be an independent variable, with potential confounders (gender, age, severity of symptoms at baseline, among others). Study II, on the other hand, will be based on the moderating effects assessment model proposed by Hayes (2013) via statistical regression test, which will not be analyzed as interactions between long-term outcomes (three years of follow-up) and as characteristics of the baseline. (gender, age, comorbidities, ADHD severity, cognitive profile, parents' mental health) with the methylphenidate group and parental training. (AU)

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