Evaluation of the effects of treatment with methylphenidate compared with parental training in preschool children with ADHD on the path of cognitive, social, emotional and psychopathological development

• Grant number: 21/08540-0
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Effective date (Start): August 01, 2021
• Effective date (End): August 31, 2022
• Field of knowledge: Health Sciences - Medicine - Psychiatry
• Principal Investigator: Guilherme Vanoni Polanczyk
• Grantee: Luis Carlos Farhat
• Host Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated research grant: 16/22455-8 - Early childhood interventions and trajectories of cognitive, social and emotional development, AP.TEM

Abstract

The present work plan has two studies: (I) evaluation of the effects of treatment with methylphenidate in comparison with parental training in preschool children with Attention Deficit Hyperactivity Disorder (ADHD) on the trajectories of cognitive, social and emotional development and on general psychopathology throughout childhood; (II) evaluation of the moderating effect of baseline characteristics of preschool children on the path of development and psychopathology throughout childhood. For study I, the psychopathological and socioemotional profile measured over time (baseline, 8 weeks, 1, 2 and 3 years) adopted using the Child Behavior Checklist (CBCL), Strength and Difficulties Questionnaire (SDQ), The Child Behavior Questionnaire (CBQ), SNAP-IV Teacher and Parental Rating Scale vary depending on (DV) continuous repeated measures. Membership in the methylphenidate group or parental training will be an independent variable, with potential confounders (gender, age, severity of symptoms at baseline, among others). Study II, on the other hand, will be based on the moderating effects assessment model proposed by Hayes (2013) via statistical regression test, which will not be analyzed as interactions between long-term outcomes (three years of follow-up) and as characteristics of the baseline. (gender, age, comorbidities, ADHD severity, cognitive profile, parents' mental health) with the methylphenidate group and parental training. (AU)

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FARHAT, LUIS C.; REID, MADISON; BLOCH, MICHAEL H.; OLFSON, EMILY. Prevalence and gender distribution of excoriation (skin-picking) disorder: A systematic review and meta-analysis. JOURNAL OF PSYCHIATRIC RESEARCH, v. 161, p. 7-pg., 2023-04-04. (21/08540-0)

RIBEIRO, TATIANE CRISTINA; FARHAT, LUIS C.; CASELLA, ERASMO B.; GRAEFF-MARTINS, ANA SOLEDADE; BARON-COHEN, SIMON; ALLISON, CARRIE; POLANCZYK, GUILHERME, V. Brazilian Portuguese Childhood Autism Spectrum Test an investigation of the factor structure of autistic traits in school-aged children. Revista Brasileira de Psiquiatria, v. 44, n. 6, p. 5-pg., 2022-11-01. (21/08540-0, 16/22455-8)

TATIANE CRISTINA RIBEIRO; LUIS C. FARHAT; ERASMO B. CASELLA; ANA SOLEDADE GRAEFF-MARTINS; SIMON BARON-COHEN; CARRIE ALLISON; GUILHERME V. POLANCZYK. Brazilian Portuguese Childhood Autism Spectrum Test: an investigation of the factor structure of autistic traits in school-aged children. Revista Brasileira de Psiquiatria, 2022-10-24. (21/08540-0, 16/22455-8)

LIN, ASHLEY; FARHAT, LUIS C.; FLORES, JOSE M.; LEVINE, JESSICA L. S.; FERNANDEZ, THOMAS, V; BLOCH, MICHAEL H.; OLFSON, EMILY. Characteristics of trichotillomania and excoriation disorder across the lifespan. PSYCHIATRY RESEARCH, v. 322, p. 8-pg., 2023-02-24. (21/08540-0)

FARHAT, LUIS C.; ZHAI, ZU WEI; HOFF, RANI A.; KRISHNAN-SARIN, SUCHITRA; POTENZA, MARC N.. An Exploratory Study of Shopping to Relieve Tension or Anxiety in Adolescents: Health Correlates and Gambling-Related Perceptions and Behaviors. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, v. 19, n. 10, p. 20-pg., 2022-05-01. (21/08540-0)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FARHAT, Luis Carlos. Attention-deficit/hyperactivity disorder across development: epidemiology, etiology, and treatment. 2023. Doctoral Thesis - Universidade de São Paulo (USP). Faculdade de Medicina (FM/SBD) São Paulo.