Characterization of the antiplasmodial activity of natural products isolated from fungal metabolites as lead candidates for Malaria

• Grant number: 22/01063-5
• Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
• Start date: March 01, 2022
• End date: August 31, 2026
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Rafael Victorio Carvalho Guido
• Grantee: Giovana Rossi Mendes
• Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 19/17721-9 - The role of Chemistry in holobiont adaptation, AP.TEM
• Associated scholarship(s): 25/02202-7 - Determining the mode of action of synthetic guanidine derivatives with antiplasmodial activity against Plasmodium falciparum, BE.EP.DD

Abstract

Malaria has a great global impact due to its burden of mortality and morbidity, consequences for the socioeconomic development of communities and the health and productivity of populations living in endemic regions of the disease. The great structural diversity of natural products as well as their potent biological activities make them attractive molecules for the discovery and development of new drugs. Among the microorganisms, fungi of different origins have been widely explored as producers of substances with antimalarial activity. On the basis of the importance of the discovery of new antiplasmodial compounds, this project aims to identify and characterize new bioactive compounds isolated from fungal metabolites as lead candidates for the discovery of new antiMalarials. The compounds will be prospected from fungal strains and their antiplasmodial and cytotoxic activities will be assessed in standardized in vitro and in vivo assays. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MENDES, GIOVANA ROSSI; NORONHA, ANDERSON L.; MOURA, IGOR M. R.; MOREIRA, NATALIA MENEZES; BONATTO, VINICIUS; BARBOSA, CAMILA S.; MALUF, SARAH EL CHAMY; DE SOUZA, GUILHERME EDUARDO; DE AMORIM, MARCELO RODRIGUES; AGUIAR, ANNA CAROLINE CAMPOS; et al. Marine Guanidine Alkaloids Inhibit Malaria Parasites Development in In Vitro, In Vivo and Ex Vivo Assays. ACS INFECTIOUS DISEASES, v. N/A, p. 14-pg., 2025-04-15. (23/09209-1, 13/07600-3, 21/03977-1, 22/01063-5, 22/15947-2, 19/17721-9, 24/04805-8, 20/01229-5, 15/01017-0, 22/01066-4)

SANTUCCI, PEDRO M.; DE OLIVEIRA, CAROLINE R.; MONTEIRO, AFIF F.; MENDES, GIOVANA R.; DE AMORIM, MARCELO R.; ROSA, GABRIEL H. S.; SETTE, LARA D.; MARCHI, RAFAEL C.; DEFLON, VICTOR M.; DOS SANTOS, PEDRO H. T.; et al. Improved production of palitantin by design of experiments and semi-synthesis of palitantin derivatives for bioactivity assessment. Fitoterapia, v. 180, p. 10-pg., 2024-12-05. (20/01229-5, 23/04020-8, 22/01063-5, 19/17721-9, 23/07721-7, 15/01017-0)