Implementation of the inverse problem and instrumental optimization for the evaluation of the disintegration process of magnetic tablets via alternating current biosusceptometry

• Grant number: 21/13661-1
• Support Opportunities: Scholarships in Brazil - Master
• Start date: June 01, 2022
• End date: August 31, 2022
• Field of knowledge: Biological Sciences - Biophysics - Biophysics of Processes and Systems
• Principal Investigator: José Ricardo de Arruda Miranda
• Grantee: Gabriele Martins Pereira
• Host Institution: Instituto de Biociências (IBB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil

Abstract

When administering a drug, factors such as the appropriate pharmaceutical form and the most efficient route of administration must be considered. Solid dosage forms, such as tablets, are usually the most chosen due to their ease of preparation, storage, transport and because they are well accepted by patients for oral treatments. However, the absorption of a drug administered through a tablet depends on its disintegration process, which is a time-dependent process and occurs under the action of a disintegrant, which promotes the breaking of the tablet into particles capable of being dissolved and absorbed. The most used technique to monitor the solid dosage forms disintegration process is scintigraphy. However alternative methods based on electromagnetism are notable. The Alternating Current Biosusceptometry (ACB) technique evolved with the advantages of being a non-invasive method and without the use of ionizing radiation, as in the case of scintigraphy. Recently, it was shown that by solving the inverse problem linked to ACB it was possible to obtain quantitative images with a better spatial resolution. Furthermore, computational simulations of new instrumental methods using ACB with new excitation fields showed that it is possible to reconstruct non-planar images with better sensitivity and spatial resolution than the previously proposed methodologies. Thus, the objective of this project is to apply the ACB technique to evaluate the process of disintegration of magnetic tablets in vitro, through static and dynamic quantitative images by solving the inverse problem and optimizing new instrumental approaches. (AU)