| Grant number: | 07/00494-2 |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| Start date: | April 01, 2007 |
| End date: | March 31, 2009 |
| Field of knowledge: | Health Sciences - Dentistry - Oral and Maxillofacial Surgery |
| Principal Investigator: | Rodrigo Cardoso de Oliveira |
| Grantee: | Marcela Mitsuko Yanai |
| Host Institution: | Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil |
Abstract The comprehension of the molecular mechanisms involved in bone repair could help in the treatment of bone defects. Fluoride is an element daily present for most people, used in drinking water (Brazil), dentifrices and also in the therapy of osteoporosis (Europe). In such case it is important the understanding of the effect of fluoride in physiologic repair in bone tissue. This study will use four groups of five 80-day-old Wistar rats (n=100) each wich will receive drinking water containing the following single doses of fluoride: 0 (control), 5, 15 and 50 ppm F, during 60 days. The incisors of the animals will be extracted. After these treatments, the animals will be euthanized at time zero and after 7, 14, 21 and 30 days post-surgical. Dental alveoli will be collected for microscopic (stained by hematoxylin eosin and immunohistochemical) and proteins analyses (bone morphogenetic proteins, BMPs; matrix metalloproteinases, MMPs; tartrate-resistant acid phosphatase, TRAP; receptor activator of NFkappaB, RANK; receptor activator of NFkappaB ligand, RANKL; osteoprotegerin, OPG). Parametric analysis will be realized by analysis of variance (Tukeys test if p<0.05). | |
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