José Andrés Yunes
CV Lattes
GoogleMyCitations
Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) (Institutional affiliation for the last research proposal) Birthplace: Argentina
Dr Yunes received his PhD in genetics by the State University of Campinas, in 1997, Seven month later he was recruited by the Boldrini Children's Hospital to start a Molecular Biology Laboratory. From 2001 to 2003 he completed his postdoctoral training at the Dana-Farber Cancer Institute, Harvard Medical School. Currently, Dr Yunes is head of the molecular biology laboratory, at Boldrini, and holds secondary appointments in Genetics at the State University of Campinas. His research work is mainly focused on elucidating the genetic and molecular mechanisms of leukemia progression and resistance to therapy. (Source: Lattes Curriculum)
- RTI.2015 - colchicine derivatives as antineoplasic agents: patent filling (2015-2016), AP.RT.INST
Abstract
Cellular microtubules are anticancer targets extensively validated in the clinic. Anti-tubulin agents that interact with the colchicine binding site are attracting a lot of interest for development of new drugs against cancer. We have designed, synthesized and tested a series of colchicine analogues and assessed their potential as anti-cancer agents. Compounds obtained showed in vitro a...
- Aberrant IL7R signaling in leukemogenesis: from the basics to potential therapeutics, AP.R
Abstract
Acute lymphoblastic leukemia (ALL) is an aggressive cancer and the most frequent childhood malignancy, arising from clonal expansion of lymphoid progenitors arrested at different stages of development. Currently, more than 80% of children with ALL, either B or T, are alive and disease-free at 5 years. Remarkable success has been recently achieved with use of imatinib for the treatment o...
- RTI.2013 - colchicine derivatives as antineoplasic agents: patent filling, AP.RT.INST
Abstract
Cellular microtubules are anticancer targets extensively validated in the clinic. Anti-tubulin agents that interact with the colchicine binding site are attracting a lot of interest for development of new drugs against cancer. We have designed, synthesized and tested a series of colchicine analogues and assessed their potential as anti-cancer agents. Compounds obtained showed in vitro a...
(Only some records are available in English at this moment)
- IGFBP7 action on TGFb/p53 pathways and corticoids resistance in Acute Lymphoblastic Leukemia, BP.DR
Abstract
Acute Lymphoblastic Leukemia (LLA) is the most common type of Cancer in childhood, accounting for about 30% of all Cancers and 80% of all leukemias occurring up to the age of 15 years. In the previous work, we verified that leukemic cells secrete several proteins, among them IGFBP7, which together with their ligands (insulin, IGF1 and IGF2) stimulate bone marrow stromal cells to produce...
- Development of an animal model of precursor B-cell acute lymphoblastic leukemia with the oncogenic IL7R mutation, BP.DR
Abstract
Acute lymphocytic leukemia (ALL) is the most common type of cancer in childhood. Eighty five percent of ALL originate from B-cell precursors (B-ALL) and 15% from thymocytes (T-ALL). Different chromosomal alterations and oncogenic mutations are known to interrupt the normal process of cell differentiation and/or induce proliferation. We have recently described oncogenic mutations in the ...
- Quantification of minimal residual disease in acute lymphoblastic leukemia by high throughput sequencing, BP.MS
Abstract
Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children. The current childhood ALL treatment protocols achieve disease-free survival rates higher than 70%. Part of this success is due to the allocation of patients in different risk groups, according to pre-treatment prognostic factors. Initial treatment response, assessed by the quantification of residual leukemic cells...
- Normalization of acute lymphoblastic leukemia gene expression data using the cellular volume, BP.MS
Abstract
The development and upgrading of global gene expression analysis technologies has been widely used in biology to understand several molecular and cellular phenomena through a gene set identification and its molecular pathways that are differentially expressed in a given test situation. In addition, gene expression profile analysis has been widely used in molecular markers search for dia...
- IGFBP7 and dexamethasone resistance in acute lymphoblastic leukemia, BP.MS
Abstract
Acute Lymphoblastic Leukemia (ALL) is the leading cancer in children. Several studies show that the interactions between leukemic blasts and bone marrow stromal cells (OM) contribute to the resistance of ALL to chemo. In the previous work, we verified that leukemic cells secrete several proteins, among them IGFBP7, which together with their ligands (insulin, IGF-1 and IGF-2) stimulate M...
(Only some records are available in English at this moment)
- Preclinical study of a colchicine binding site tubulin inhibitor with potent anti-leukemia activity and low toxicity, BE.EP.DR
Abstract
Acute lymphoblastic leukemia (ALL) has an excellent cure rate, but 20% of patients still relapsed. Relapsed leukemia cells show a higher expression of membrane-associated ATP-binding cassette (ABC) transporters when compared to leukemic cells at diagnosis. Overexpression of ABC transporters decreases intracellular drug levels, consequently limiting drug cytotoxicity since they pump drug...
- In vivo leukemogenic potential of the mutant CD2-CRE/IL7R, BE.EP.MS
Abstract
Acute lymphoid leukemia (ALL) is a cancer derived from immature lymphoid precursors T (ALL-T) or B (ALL-B). Nine% of the T-ALL has a mutation at the interleukin 7 receptor (IL7R), which confer constitutive activation of the JAK-STAT and PIK3/AKT pathways and potentiates cell survival and proliferation. To study the leukemogenic potential of this mutation in vivo, the B6-IL7RCPT animal m...
- Mechanism of activation of the cystein-mutant and wild type IL7R receptors, BE.EP.DR
Abstract
IL-7Ra is a transmembrane receptor that lacks kinase activity. Signal transduction by the IL-7R± is dependent on the associated protein tyrosine kinase JAK1 (Janus kinase 1), anchored to the intracellular domain of the receptor. IL-7R± forms a heterodimer with the gamma chain transmembrane receptor, which brings JAK3. Signaling occurs only in presence of IL-7, when JAK1 and JAK3 trans-p...
(Only some records are available in English at this moment)
| 11 / 7 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 31 / 20 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 49 / 34 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 14 |
| Citations | 482 |
| Cit./Article | 34.4 |
| Data from Web of Science | |
FERNANDES, MONICA T.; GHEZZO, MARINELLA N.; SILVEIRA, ANDRE B.; KALATHUR, RAVI K.; POVOA, VANDA; RIBEIRO, ANA R.; BRANDALISE, SILVIA R.; DEJARDIN, EMMANUEL; ALVES, NUNO L.; GHYSDAEL, JACQUES; et al. Lymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology, v. 171, n. 5, p. 736-751, DEC 2015. Web of Science Citations: 9. (08/10034-1, 12/12802-1)
SILVEIRA, ANDRE BORTOLINI; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LIBANIO RODRIGUES, GISELE OLINTO; LEAL, PAULO CESAR; CARDOSO, BRUNO ANTONIO; BARATA, JOAO TABORDA; YUNES, ROSENDO AUGUSTO; TONIN ZANCHIN, NILSON IVO; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. ONCOTARGET, v. 6, n. 15, p. 13105-13118, MAY 30 2015. Web of Science Citations: 10. (08/10034-1)
DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LEAL, PAULO C.; BHASIN, MANOJ K.; ZENATTI, PRISCILA PINI; NUNES, RICARDO J.; YUNES, ROSENDO A.; NOWILL, ALEXANDRE E.; LIBERMANN, TOWIA A.; ZERBINI, LUIZ FERNANDO; et al. SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1. PLoS One, v. 10, n. 8, AUG 24 2015. Web of Science Citations: 5. (05/02390-4, 08/02106-2)
DA SILVA, RODRIGO FERNANDES; CARDOZO, DANIELA MAIRA; LIBANIO RODRIGUES, GISELE OLINTO; DE SOUZA-ARAUJO, CAROLINE NATANIA; MIGITA, NATACHA AZUSSA; LUCCI DE ANGELO ANDRADE, LILIANA APARECIDA; DERCHAIN, SOPHIE; YUNES, JOSE ANDRES; GUIMARAES, FERNANDO. CAISMOV24, a new human low-grade serous ovarian carcinoma cell line. BMC CANCER, v. 17, NOV 13 2017. Web of Science Citations: 0. (11/14520-0, 16/07822-4, 14/07401-3, 12/12802-1)
MILANI, MATEUS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; DE VASCONCELLOS, JAIRA FERREIRA; BRANDALISE, SILVIA REGINA; NOWILL, ALEXANDRE EDUARDO; YUNES, JOSE ANDRES. Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice. PLoS One, v. 10, n. 6, JUN 11 2015. Web of Science Citations: 3. (08/10034-1, 12/12802-1)
MENDES, RUI D.; SARMENTO, LEONOR M.; CANTE-BARRETT, KIRSTEN; ZUURBIER, LINDA; BUIJS-GLADDINES, JESSICA G. C. A. M.; POVOA, VANDA; SMITS, WILLEM K.; ABECASIS, MIGUEL; YUNES, J. ANDRES; SONNEVELD, EDWIN; et al. PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events. Blood, v. 124, n. 4, p. 567-578, JUL 24 2014. Web of Science Citations: 38. (08/10034-1)
MANSUR, MARCELA BRAGA; HASSAN, ROCIO; BARBOSA, THAYANA C.; SPLENDORE, ALESSANDRA; JOTTA, PATRICIA Y.; YUNES, JOSE ANDRES; WIEMELS, JOSEPH L.; POMBO-DE-OLIVEIRA, MARIA S.. Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia. BMC CANCER, v. 12, JAN 6 2012. Web of Science Citations: 23. (08/10034-1)
SILVA, ANA; LARANJEIRA, ANGELO B. A.; MARTINS, LEILA R.; CARDOSO, BRUNO A.; DEMENGEOT, JOCELYNE; ANDRES YUNES, J.; SEDDON, BENEDICT; BARATA, JOAO T.. IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias. Cancer Research, v. 71, n. 14, p. 4780-4789, JUL 15 2011. Web of Science Citations: 57. (08/10034-1)
ZENATTI, PRISCILA P.; RIBEIRO, DANIEL; LI, WENQING; ZUURBIER, LINDA; SILVA, MILENE C.; PAGANIN, MADDALENA; TRITAPOE, JULIA; HIXON, JULIE A.; SILVEIRA, ANDRE B.; CARDOSO, BRUNO A.; et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature Genetics, v. 43, n. 10, p. 932-U31, OCT 2011. Web of Science Citations: 186. (08/10034-1)
LARANJEIRA, A. B. A.; DE VASCONCELLOS, J. F.; SODEK, L.; SPAGO, M. C.; FORNAZIM, M. C.; TONE, L. G.; BRANDALISE, S. R.; NOWILL, A. E.; YUNES, J. A.. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. LEUKEMIA, v. 26, n. 5, p. 1001-1011, MAY 2012. Web of Science Citations: 14. (08/10034-1, 08/02106-2)
JOTTA‚ PY; GANAZZA‚ MA; SILVA‚ A.; VIANA‚ MB; DA SILVA‚ MJ; ZAMBALDI‚ LJG; BARATA‚ JT; BRANDALISE‚ SR; YUNES‚ JA. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. LEUKEMIA, v. 24, n. 1, p. 239-242, 2009. (08/10034-1)
DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; TONIN ZANCHIN, NILSON IVO; OTUBO, ROSEMARY; VAZ, THAIS HALINE; CARDOSO, ANGELO ALMEIDA; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. Increased CCL2 and IL-8 in the Bone Marrow Microenvironment in Acute Lymphoblastic Leukemia. PEDIATRIC BLOOD & CANCER, v. 56, n. 4, p. 568-577, APR 2011. Web of Science Citations: 24. (08/02106-2, 05/02390-4)
TAMURA, R. E.; DE VASCONCELLOS, J. F.; SARKAR, D.; LIBERMANN, T. A.; FISHER, P. B.; ZERBINI, L. F.. GADD45 Proteins: Central Players in Tumorigenesis. CURRENT MOLECULAR MEDICINE, v. 12, n. 5, p. 634-651, JUN 2012. Web of Science Citations: 108.
CAMPOS, LIVIA WEIJENBORG; ZENATTI, PRISCILA PINI; PISSINATO, LEONARDO GRANATO; RODRIGUES, GISELE O. LIBANIO; ARTICO, LEONARDO LUIS; GUIMARAES, THAIS RAFAEL; ARCHANGELO, LETICIA FROHLICH; MARTINEZ, LEANDRO; BROOKS, ANDREW J.; YUNES, JOSE ANDRES. Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity. Blood, v. 133, n. 11, p. 1259-1263, MAR 14 2019. Web of Science Citations: 0. (10/16947-9, 12/12802-1, 14/20015-5, 13/08293-7)
DOS SANTOS, ERIC F. S.; CURY, NATHALIA M.; DO NASCIMENTO, TAINARA A.; RAMINELLI, CRISTIANO; CASAGRANDE, GLEISON A.; PEREIRA, CLAUDIO M. P.; SIMIONATTO, EUCLESIO; YUNES, JOSE A.; PIZZUTI, LUCAS. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217+, FEB 2017. Web of Science Citations: 5. (12/12802-1)
ERIC F. S. DOS SANTOS; NATHÁLIA M. CURY; TAINARA A. DO NASCIMENTO; CRISTIANO RAMINELLI; GLEISON A. CASAGRANDE; CLAUDIO M. P. PEREIRA; EUCLÉSIO SIMIONATTO; JOSÉ A. YUNES; LUCAS PIZZUTI. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217-224, Fev. 2017. (12/12802-1)
SEQUÊNCIAS DE DNA, KIT E USO PARA DETECÇÃO DA MUTAÇÃO TP53 R337H BR1020120311828 - Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB); Universidade Estadual de Campinas (UNICAMP). José Andres Yunes; Isabel Pereira Caminha; Ana Luiza Ongaro Seidinger Conte; Carmen Sílvia Gabetta - December 2012, 07
ACIL-HIDRAZONAS COMO PROTÓTIPO DE NOVOS FÁRMACOS PARA LEUCEMIA LINFÓIDE AGUDA (LLA) PI1107312-8 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2011, 25
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CA2869807 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CN201280063518 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF EP20120851308 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF JP2014542646 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF PCT/BR2012/000480 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
PROCESSO DE CONVERSÃO EM PLANTAS DE PRÓ-PEPTÍDEOS EM PEPTÍDEOS BIOATIVOS, ATRAVÉS DE ATIVIDADE PROTEOLÍTICA CONTROLADA, UTILIZANDO VETOR E CASSETE PARA EXPRESSÃO DE UMA ENZIMA CAPAZ DE REALIZAR ESTA CONVERSÃO, PLANTAS TRANSGÊNICAS E HÍBRIDOS DERIVADOS, CONTENDO CASSETES DE EXPRESSÃO E USO E COMPOSIÇÃO FARMACÊUTICA DAS PROTEÍNAS RECOMBINANTES ASSIM PRODUZIDAS PI0405361-3 - Universidade Estadual de Campinas (UNICAMP). Mário Del Giúdice Paniago; Adilson Leite - November 2004, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF RU2014125519 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF US14/360,279 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26