CV Lattes
GoogleMyCitations
ORCID
Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB) (Institutional affiliation for the last research proposal) Birthplace: Argentina
Dr Yunes received his PhD in genetics by the State University of Campinas, in 1997, Seven month later he was recruited by the Boldrini Children's Hospital to start a Molecular Biology Laboratory. From 2001 to 2003 he completed his postdoctoral training at the Dana-Farber Cancer Institute, Harvard Medical School. Currently, Dr Yunes is head of the molecular biology laboratory, at Boldrini, and holds secondary appointments in Genetics at the State University of Campinas. His research work is mainly focused on elucidating the genetic and molecular mechanisms of leukemia progression and resistance to therapy. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The enzyme L-asparaginase II is one of the drugs of choice for the polychemotherapeutic treatment of acute lymphoblastic leukemia (ALL) in children and adults. Despite being a rare disease, ALL is the most common cancer in children and accounts for 25% of all cancers in children up to 15 years of age. Commonly, neoplastic cells use plasma asparagine for the synthesis of proteins. Asparagi…
Currently, the Boldrini Research Center(BRC)team consists of 11 (eleven) doctors and approximately 25 technicians and graduate/undergraduate students (doctorate, master or scientific initiation). Four main projects are underway: (i) analysis of minimal residual disease in acute lymphoblastic leukemia, (ii) study of leukemogenesis using an animal model of floxed IL7R mutant, (iii) producti…
Cellular microtubules are anticancer targets extensively validated in the clinic. Anti-tubulin agents that interact with the colchicine binding site are attracting a lot of interest for development of new drugs against cancer. We have designed, synthesized and tested a series of colchicine analogues and assessed their potential as anti-cancer agents. Compounds obtained showed in vitro ant…
Acute lymphoblastic leukemia (ALL) is an aggressive cancer and the most frequent childhood malignancy, arising from clonal expansion of lymphoid progenitors arrested at different stages of development. Currently, more than 80% of children with ALL, either B or T, are alive and disease-free at 5 years. Remarkable success has been recently achieved with use of imatinib for the treatment of …
(Only some records are available in English at this moment)
Leukemia is a malignant disease characterized by uncontrolled proliferation and interruption of the development of leukocyte precursors in the bone marrow. In this project, the Acute Lymphoid Leukemia (ALL) and Chronic Myeloid Leukemia (CML) carrying the translocation t(9; 22) will be studied [BCR-ABL1], which results in the Philadelphia chromosome that is related to high rates of recurre…
Approximately 9% of pediatric acute T-cell lymphoid leukemias (T-ALL) present a mutation with insertion of a cysteine residue in the justamembrane portion of the IL7Ra receptor, which leads to homodimerization and constitutive JAK / STAT signaling, contributing to leukemogenesis. The mutations are concentrated in a 26bp stretch of exon 6 of the IL7R gene (hotspot) and are characterized by…
Acute Lymphoblastic Leukemia (LLA) is the most common type of Cancer in childhood, accounting for about 30% of all Cancers and 80% of all leukemias occurring up to the age of 15 years. In the previous work, we verified that leukemic cells secrete several proteins, among them IGFBP7, which together with their ligands (insulin, IGF1 and IGF2) stimulate bone marrow stromal cells to produce a…
(Only some records are available in English at this moment)
Leukemias are hematological neoplastic diseases, that are characterized by uncontrolledproliferation of hematopoietic cells and are classified according to the phenotype of theaffected cell. In this study we will emphasize acute promyelocytic leukemia (APL),belonging to the group of acute myeloid leukemias (AML), subgroup M3 or M3 variant. APLis characterized by chromosomal translocation …
(Only some records are available in English at this moment)
The oncogenic IL7R is known to activate three pathways in acute lymphoid leukemia (ALL): JAK/STAT, PI3K/AKT/mTOR and RAS/MEK/ERK. However, the activation of RAS/MEK/ERK has not been characterized. Mutations in RAS/MEK/ERK are recurrent in human ALL (7/15 cases of ALL with mutations in the IL7R have cooccurring mutations in genes of the RAS/MEK/ERK pathway) and in murine ALL originating fr…
Acute lymphoblastic leukemia (ALL) has an excellent cure rate, but 20% of patients still relapsed. Relapsed leukemia cells show a higher expression of membrane-associated ATP-binding cassette (ABC) transporters when compared to leukemic cells at diagnosis. Overexpression of ABC transporters decreases intracellular drug levels, consequently limiting drug cytotoxicity since they pump drug m…
Acute lymphoid leukemia (ALL) is a cancer derived from immature lymphoid precursors T (ALL-T) or B (ALL-B). Nine% of the T-ALL has a mutation at the interleukin 7 receptor (IL7R), which confer constitutive activation of the JAK-STAT and PIK3/AKT pathways and potentiates cell survival and proliferation. To study the leukemogenic potential of this mutation in vivo, the B6-IL7RCPT animal mod…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 14 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 34 / 23 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 59 / 42 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 22 |
| Citations | 488 |
| Cit./Article | 22.2 |
| Data from Web of Science | |
CAMPOS, LIVIA WEIJENBORG; ZENATTI, PRISCILA PINI; PISSINATO, LEONARDO GRANATO; RODRIGUES, GISELE O. LIBANIO; ARTICO, LEONARDO LUIS; GUIMARAES, THAIS RAFAEL; ARCHANGELO, LETICIA FROHLICH; MARTINEZ, LEANDRO; BROOKS, ANDREW J.; YUNES, JOSE ANDRES. Oncogenic basic amino acid insertions at the extracellular juxtamembrane region of IL7RA cause receptor hypersensitivity. Blood, v. 133, n. 11, p. 1259-1263, MAR 14 2019. Web of Science Citations: 2. (12/12802-1, 14/20015-5, 10/16947-9, 13/08293-7)
CURY, NATHALIA MORENO; CAPITAO, REBECA MONIQUE; BORGES DE ALMEIDA, RENAN DO CANTO; ARTICO, LEONARDO LUIS; CORREA, JULIANA RONCHI; SIMAO DOS SANTOS, ERIC FRANCISCO; YUNES, JOSE ANDRES; DUARTE CORREIA, CARLOS ROQUE. Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v. 181, NOV 1 2019. Web of Science Citations: 0. (13/07600-3, 17/02400-7, 14/25770-6, 17/03239-5, 17/14737-6, 14/08247-8)
SILVEIRA, ANDRE BORTOLINI; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LIBANIO RODRIGUES, GISELE OLINTO; LEAL, PAULO CESAR; CARDOSO, BRUNO ANTONIO; BARATA, JOAO TABORDA; YUNES, ROSENDO AUGUSTO; TONIN ZANCHIN, NILSON IVO; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia. ONCOTARGET, v. 6, n. 15, p. 13105-13118, MAY 30 2015. (08/10034-1)
FERNANDES, MONICA T.; GHEZZO, MARINELLA N.; SILVEIRA, ANDRE B.; KALATHUR, RAVI K.; POVOA, VANDA; RIBEIRO, ANA R.; BRANDALISE, SILVIA R.; DEJARDIN, EMMANUEL; ALVES, NUNO L.; GHYSDAEL, JACQUES; et al. Lymphotoxin-beta receptor in microenvironmental cells promotes the development of T-cell acute lymphoblastic leukaemia with cortical/mature immunophenotype. British Journal of Haematology, v. 171, n. 5, p. 736-751, DEC 2015. (12/12802-1, 08/10034-1)
ERIC F. S. DOS SANTOS; NATHÁLIA M. CURY; TAINARA A. DO NASCIMENTO; CRISTIANO RAMINELLI; GLEISON A. CASAGRANDE; CLAUDIO M. P. PEREIRA; EUCLÉSIO SIMIONATTO; JOSÉ A. YUNES; LUCAS PIZZUTI. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217-224, Fev. 2017. (12/12802-1)
LARANJEIRA, A. B. A.; DE VASCONCELLOS, J. F.; SODEK, L.; SPAGO, M. C.; FORNAZIM, M. C.; TONE, L. G.; BRANDALISE, S. R.; NOWILL, A. E.; YUNES, J. A.. IGFBP7 participates in the reciprocal interaction between acute lymphoblastic leukemia and BM stromal cells and in leukemia resistance to asparaginase. LEUKEMIA, v. 26, n. 5, p. 1001-1011, MAY 2012. (08/02106-2, 08/10034-1)
SILVA, ANA; LARANJEIRA, ANGELO B. A.; MARTINS, LEILA R.; CARDOSO, BRUNO A.; DEMENGEOT, JOCELYNE; ANDRES YUNES, J.; SEDDON, BENEDICT; BARATA, JOAO T.. IL-7 Contributes to the Progression of Human T-cell Acute Lymphoblastic Leukemias. Cancer Research, v. 71, n. 14, p. 4780-4789, JUL 15 2011. (08/10034-1)
JOTTA‚ PY; GANAZZA‚ MA; SILVA‚ A.; VIANA‚ MB; DA SILVA‚ MJ; ZAMBALDI‚ LJG; BARATA‚ JT; BRANDALISE‚ SR; YUNES‚ JA. Negative prognostic impact of PTEN mutation in pediatric T-cell acute lymphoblastic leukemia. LEUKEMIA, v. 24, n. 1, p. 239-242, 2009. (08/10034-1)
CURY, NATHALIA MORENO; MUEHLETHALER, TOBIAS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; CANEVAROLO, RAFAEL RENATINO; ZENATTI, PRISCILA PINI; LUCENA-AGELL, DANIEL; BARASOAIN, ISABEL; SONG, CHUNHUA; SUN, DONGXIAO; DOVAT, SINISA; et al. Structural Basis of Colchicine-Site targeting Acylhydrazones active against Multidrug-Resistant Acute Lymphoblastic Leukemia. ISCIENCE, v. 21, p. 95+, NOV 22 2019. Web of Science Citations: 0. (14/08247-8, 17/14737-6)
CAMPOS, LIVIA WEIJENBORG; PISSINATO, LEONARDO GRANATO; YUNES, JOSE ANDRES. Deleterious and Oncogenic Mutations in the IL7RA. CANCERS, v. 11, n. 12, DEC 2019. Web of Science Citations: 0. (12/12802-1, 14/20015-5)
ALMEIDA, AFONSO R. M.; NETO, JOAO L.; CACHUCHO, ANA; EUZEBIO, MAYARA; MENG, XIANGYU; KIM, RATHANA; FERNANDES, MARTA B.; RAPOSO, BEATRIZ; OLIVEIRA, MARIANA L.; RIBEIRO, DANIEL; et al. Interleukin-7 receptor alpha mutational activation can initiate precursor B-cell acute lymphoblastic leukemia. NATURE COMMUNICATIONS, v. 12, n. 1, DEC 14 2021. Web of Science Citations: 0. (12/03660-9, 14/20015-5, 12/12802-1, 17/02400-7, 17/10653-2, 16/07724-2)
GIUSTI, GUILHERME NAVARRO NILO; JOTTA, PATRICIA YOSHIOKA; LOPES, CAROLINE DE OLIVEIRA; GANAZZA, MONICA APARECIDA; AZEVEDO, AMILCAR CARDOSO; BRANDALISE, SILVIA REGINA; MEIDANIS, JOAO; YUNES, JOSE ANDRES. Test trial of spike-in immunoglobulin heavy-chain (IGH) controls for next generation sequencing quantification of minimal residual disease in acute lymphoblastic leukaemia. British Journal of Haematology, v. 189, n. 4, MAR 2020. Web of Science Citations: 0. (18/00031-7, 17/03942-8)
MENEGHETTI, DALILA; CEZAROTTO, VERCIANE SCHNEIDER; DO NASCIMENTO, NATALIA PAIVA; MIGITA, NATACHA AZUSSA; CORREA, JULIANA RONCHI; RICCIO, MARIA FRANCESCA; ZAMBALDI, LILIAN GIROTTO; YUNES, JOSE ANDRES; ARTICO, LEONARDO LUIS. Hydroalcoholic leaves extract of Vaccinium ashei Reade promotes cell cycle arrest and apoptosis on T-cell acute lymphoblastic leukemia. NATURAL PRODUCT RESEARCH, OCT 2021. Web of Science Citations: 0. (19/04943-3)
SEIDINGER, ANA L.; CAMINHA, ISABEL P.; MASTELLARO, MARIA J.; GABETTA, CARMEN S.; NOWILL, ALEXANDRE E.; PINHEIRO, VITORIA R. P.; YUNES, JOSE A.. TP53p.Arg337His geographic distribution correlates with adrenocortical tumor occurrence. MOLECULAR GENETICS & GENOMIC MEDICINE, JUN 2020. Web of Science Citations: 0. (11/05657-2)
ARTICO, LEONARDO LUIS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; CAMPOS, LIVIA WEIJENBORG; CORREA, JULIANA RONCHI; ZENATTI, PRISCILA PINI; CAMPELLO CARVALHEIRA, JOSE BARRETO; BRAMBILLA, SANDRA REGINA; NOWILL, ALEXANDRE EDUARDO; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia. BLOOD ADVANCES, v. 5, n. 18, p. 3633-3646, SEP 28 2021. Web of Science Citations: 0. (14/20015-5, 12/12802-1)
DA SILVA, RODRIGO FERNANDES; CARDOZO, DANIELA MAIRA; LIBANIO RODRIGUES, GISELE OLINTO; DE SOUZA-ARAUJO, CAROLINE NATANIA; MIGITA, NATACHA AZUSSA; LUCCI DE ANGELO ANDRADE, LILIANA APARECIDA; DERCHAIN, SOPHIE; YUNES, JOSE ANDRES; GUIMARAES, FERNANDO. CAISMOV24, a new human low-grade serous ovarian carcinoma cell line. BMC CANCER, v. 17, NOV 13 2017. (11/14520-0, 16/07822-4, 14/07401-3, 12/12802-1)
DOS SANTOS, ERIC F. S.; CURY, NATHALIA M.; DO NASCIMENTO, TAINARA A.; RAMINELLI, CRISTIANO; CASAGRANDE, GLEISON A.; PEREIRA, CLAUDIO M. P.; SIMIONATTO, EUCLESIO; YUNES, JOSE A.; PIZZUTI, LUCAS. Ultrasound-Promoted Synthesis of 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1carboximidamides and Anticancer Activity Evaluation in Leukemia Cell Lines. Journal of the Brazilian Chemical Society, v. 28, n. 2, p. 217+, FEB 2017. (12/12802-1)
MENDES, RUI D.; SARMENTO, LEONOR M.; CANTE-BARRETT, KIRSTEN; ZUURBIER, LINDA; BUIJS-GLADDINES, JESSICA G. C. A. M.; POVOA, VANDA; SMITS, WILLEM K.; ABECASIS, MIGUEL; YUNES, J. ANDRES; SONNEVELD, EDWIN; et al. PTEN microdeletions in T-cell acute lymphoblastic leukemia are caused by illegitimate RAG-mediated recombination events. Blood, v. 124, n. 4, p. 567-578, JUL 24 2014. (08/10034-1)
MILANI, MATEUS; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; DE VASCONCELLOS, JAIRA FERREIRA; BRANDALISE, SILVIA REGINA; NOWILL, ALEXANDRE EDUARDO; YUNES, JOSE ANDRES. Plasma Hsp90 Level as a Marker of Early Acute Lymphoblastic Leukemia Engraftment and Progression in Mice. PLoS One, v. 10, n. 6, JUN 11 2015. (12/12802-1, 08/10034-1)
DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; TONIN ZANCHIN, NILSON IVO; OTUBO, ROSEMARY; VAZ, THAIS HALINE; CARDOSO, ANGELO ALMEIDA; BRANDALISE, SILVIA REGINA; YUNES, JOSE ANDRES. Increased CCL2 and IL-8 in the Bone Marrow Microenvironment in Acute Lymphoblastic Leukemia. PEDIATRIC BLOOD & CANCER, v. 56, n. 4, p. 568-577, APR 2011. (08/02106-2, 05/02390-4)
ZENATTI, PRISCILA P.; RIBEIRO, DANIEL; LI, WENQING; ZUURBIER, LINDA; SILVA, MILENE C.; PAGANIN, MADDALENA; TRITAPOE, JULIA; HIXON, JULIE A.; SILVEIRA, ANDRE B.; CARDOSO, BRUNO A.; et al. Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nature Genetics, v. 43, n. 10, p. 932-U31, OCT 2011. (08/10034-1)
TAMURA, R. E.; DE VASCONCELLOS, J. F.; SARKAR, D.; LIBERMANN, T. A.; FISHER, P. B.; ZERBINI, L. F.. GADD45 Proteins: Central Players in Tumorigenesis. CURRENT MOLECULAR MEDICINE, v. 12, n. 5, p. 634-651, JUN 2012.
MANSUR, MARCELA BRAGA; HASSAN, ROCIO; BARBOSA, THAYANA C.; SPLENDORE, ALESSANDRA; JOTTA, PATRICIA Y.; YUNES, JOSE ANDRES; WIEMELS, JOSEPH L.; POMBO-DE-OLIVEIRA, MARIA S.. Impact of complex NOTCH1 mutations on survival in paediatric T-cell leukaemia. BMC CANCER, v. 12, JAN 6 2012. (08/10034-1)
DE VASCONCELLOS, JAIRA FERREIRA; ALBERTONI LARANJEIRA, ANGELO BRUNELLI; LEAL, PAULO C.; BHASIN, MANOJ K.; ZENATTI, PRISCILA PINI; NUNES, RICARDO J.; YUNES, ROSENDO A.; NOWILL, ALEXANDRE E.; LIBERMANN, TOWIA A.; ZERBINI, LUIZ FERNANDO; et al. SB225002 Induces Cell Death and Cell Cycle Arrest in Acute Lymphoblastic Leukemia Cells through the Activation of GLIPR1. PLoS One, v. 10, n. 8, AUG 24 2015. (08/02106-2, 05/02390-4)
(References retrieved automatically from State of São Paulo Research Institutions)
VASCONCELLOS, Jaíra Ferreira de. Identificação e estudo de genes diferencialmente expressos pelo estroma da medula ossea leucemica. Tese (Doutorado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (06/01158-3)
MILANI, Mateus. Desenvolvimento de modelo animal de leucemia linfóide aguda pediátrica : teste ELISA para monitorar a progressão da leucemia. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas. (11/01725-3)
CAMINHA, Isabel Pereira. Prevalência da mutação germinativa TP53 p.R337H na região metropolitana de Campinas e cidades circunvizinhas. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas. (11/05657-2)
JOTTA, Patricia Yoshioka. Mutações de PTEN nas leucemias linfóides agudas T. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (07/00926-0)
VASCONCELOS, Victor Sande. Normalização de dados de expressão gênica de leucemia linfóide aguda pelo volume celular. Dissertação (Mestrado) - Universidade Estadual de Campinas, Instituto de Biologia. (17/02301-9)
ARTICO, Leonardo Luís. IGFBP7 como um novo alvo terapêutico na leucemia linfoide aguda : IGFBP7 as a new therapeutic target in acute lymphoblastic leukemia. Dissertação (Mestrado) - Universidade Estadual de Campinas, Instituto de Biologia. (17/03239-5)
RODRIGUES, Gisele Olinto Libanio. Identificação de mutações funcionalmente associadas ao mutante IL7R'alfa' na LLA-T : Identification of mutations functionally associated with IL7R'alpha' mutant in T-ALL. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/10284-3)
CAMPOS, Lívia Weijenborg. Estudo dos mecanismos de dimerização e sinalização do IL7RA mutante : Study on the mutant IL7RA mechanisms of dimerization and signaling. Tese (Doutorado) - Universidade Estadual de Campinas, Instituto de Biologia. (12/07992-6)
LARANJEIRA, Angelo Brunelli Albertoni. Participação do IGFBP7 na interação leucemia-estroma e na resistência a quimioterapia. Tese (Doutorado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP). (08/02106-2)
CANEVAROLO, Rafael Renatino. Resistência ao metotrexato está diretamente associada à concentração de glutationa em linhagens de leucemia linfoide aguda. Tese (Doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas. (12/11952-0)
CANEVAROLO, Rafael Renatino. Resistência ao metotrexato está diretamente associada à concentração de glutationa em linhagens de leucemia linfoide aguda. Tese (Doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas. (12/11952-0)
CANEVAROLO, Rafael Renatino. Metabolômica da resistência ao metotrexato na leucemia linfóide aguda. Dissertação (Mestrado) - Faculdade de Ciências Médicas. Universidade Estadual de Campinas (UNICAMP). (09/04167-1)
SEQUÊNCIAS DE DNA, KIT E USO PARA DETECÇÃO DA MUTAÇÃO TP53 R337H BR1020120311828 - Centro Infantil de Investigações Hematológicas Dr Domingos A Boldrini (CIB); Universidade Estadual de Campinas (UNICAMP). José Andres Yunes; Isabel Pereira Caminha; Ana Luiza Ongaro Seidinger Conte; Carmen Sílvia Gabetta - December 2012, 07
ACIL-HIDRAZONAS COMO PROTÓTIPO DE NOVOS FÁRMACOS PARA LEUCEMIA LINFÓIDE AGUDA (LLA) PI1107312-8 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2011, 25
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CA2869807 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Taisa Regina Stumpf; Paulo César Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; Rosendo A. Yunes; Ângelo Bruneli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF CN201280063518 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF EP20120851308 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF JP2014542646 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF PCT/BR2012/000480 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
PROCESSO DE CONVERSÃO EM PLANTAS DE PRÓ-PEPTÍDEOS EM PEPTÍDEOS BIOATIVOS, ATRAVÉS DE ATIVIDADE PROTEOLÍTICA CONTROLADA, UTILIZANDO VETOR E CASSETE PARA EXPRESSÃO DE UMA ENZIMA CAPAZ DE REALIZAR ESTA CONVERSÃO, PLANTAS TRANSGÊNICAS E HÍBRIDOS DERIVADOS, CONTENDO CASSETES DE EXPRESSÃO E USO E COMPOSIÇÃO FARMACÊUTICA DAS PROTEÍNAS RECOMBINANTES ASSIM PRODUZIDAS PI0405361-3 - Universidade Estadual de Campinas (UNICAMP). Mário Del Giúdice Paniago; Adilson Leite - November 2004, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF RU2014125519 - Alessandra Mascarello; André Bortolini Silveira; Carolina Pereira de Souza Melo; José Andres Yunes; Louise Domeneghini Chiaradia; Paulo Cesar Leal; Rafael Renatino Canevarolo; Ricardo José Nunes; Rosendo Augusto Yunes; Taisa Regina Stumpf; Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26
ACYL-HYDRAZONE AND OXADIAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND USES THEREOF US14/360,279 - Universidade Federal de Santa Catarina (UFSC). Ricardo José Nunes; Alessandra Mascarello; Rosendo Augusto Yunes; Taisa Regina Stumpf; Paulo Cesar Leal; José Andres Yunes; Carolina Pereira de Souza Melo; Rafael Renatino Canevarolo; Louise Domeneghini Chiaradia; André Bortolini Silveira; Anqelo Brunelli Albertoni Laranjeira - November 2012, 26