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Universidade Estadual Paulista (UNESP). Campus de São José do Rio Preto. Instituto de Biociências, Letras e Ciências Exatas (IBILCE) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Raghuvir Krishnaswamy Arni in research grants and scholarships supported by FAPESP.
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In recent years, the expansion of chemical libraries beyond 10E8 compounds has opened new avenues for discovering hits against diverse targets. However, the sheer size of these libraries poses a challenge for traditional virtual screening (VS), particularly for academic researchers, given the substantial computational resources required for this undertaking. In response to the previous ch…
The interior of organisms constitute complex, crowded and dynamic environments with little semblance to the experiments conducted on isolated proteins. Data on the possible interactions that specific proteins can participate in within these crowded physiological environments is fundamental to understanding the multiple roles that are frequently played by proteins. High-resolution structur…
The craft beer market in Brazil has been growing exponentially and is against the economic crisis that the country has been facing. In the last decade, production grew 64%, jumping from 8.2 billion to 13.4 billion liters / year and the number of breweries grew by an impressive 292%. In the last 3 years, the number of factories has doubled, reaching more than one thousand registered with t…
This collaborative research project aims to express, characterize and determine the crystal structures of a number of enzymes. Crystallography provides accurate, static images of the three-dimensional structures of biological macromolecules at the atomic level that is unsurpassed by any other technique in its degree of detail and precision.Structural models help elucidate enzyme mechanism…
The Multi-User Equipment Program (EMU) FAPESP has infrastructural nature and is intended for the purchase of scientific instruments characterized by having continuous utility for a group of researchers with extensive experience and proven competence. The program contemplates and encourages the structuring and/or centralized equipment Multi-User laboratories (in certain research areas such…
(Only some records are available in English at this moment)
The objective of the project is to explore the multiple functions of proteins produced by pathogenic microorganisms through an interdisciplinary approach that includes techniques for expression and purification of recombinant proteins, cultivation of cell cultures, phage display, protein crystallography, cryoelectron microscopy (Cryo-EM) , computational biology and metabolomics.
In recent years, the expansion of chemical libraries beyond 10E8 compounds has opened new avenues for discovering hits against diverse targets. However, the sheer size of these libraries poses a challenge for traditional virtual screening (VS), particularly for academic researchers, given the substantial computational resources required for this undertaking. In response to the previous ch…
(Only some records are available in English at this moment)
A protein is a large biological molecule composed of amino acids, folded into complex three-dimensional structures. Proteins play crucial roles in various biological functions, acting as enzymes, structural components, and signaling molecules. Proteins can have multiple roles that are still poorly understood, related to their surface, which often presents regions of secondary bindings (al…
A protein is a large biological molecule composed of amino acids, folded into complex three-dimensional structures. Proteins play crucial roles in various biological functions, acting as enzymes, structural components, and signaling molecules. Proteins can have multiple roles that are still poorly understood, related to their surface, which often presents regions of secondary bindings (al…
Mammaliicoccus sciuri is a pathogenic and commensal bacterium with clinical and veterinary importance. M. sciuri was described as the etiological agent of exudative epidermitis in swine and the main virulence factor involved was exfoliative toxin C (ExhC). M. sciuri ExhC also causes epidermal exfoliation in newborn mice, necrosis in renal fibroblasts in newborn hamsters, and inhibition of…
(Only some records are available in English at this moment)
Staphylococcus sciuri is a commensal and pathogenic bacterium of significant clinical and veterinary relevance. Recently, a strain of S. sciuri has been described as the etiologic agent of exudative epidermitis (EE) in pigs and the main virulence factor involved in this clinical manifestation was the exfoliative protein C (ExhC). This enzyme belongs to the group of exfoliative toxins (ETs…
Several Staphylococcus spp. express exfoliative toxins (ETs), which act as key virulence factors facilitating host invasion and infection. S. aureus is a notorious pathogen that can produce different ETs (ETA to ETE) causing serious diseases in humans and animals of economic value, such as the staphylococcal scalded skin syndrome (SSSS) and mastitis. Other species, e.g., S. sciuri and S. …
Infections by alpha viruses represent a very serious health problem especially in developingcountries where the precarious public health system is already over stressed. A leading example is infection by the Chikungunya virus which results in considerable social and economic trauma and requires urgent attention. The lack of efficacious treatments is compounded by potential coinfection by …
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 17 / 9 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 33 / 21 | Completed scholarships in Brazil |
| 7 / 6 | Completed scholarships abroad |
| 63 / 42 | All research grants and scholarships |
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