MD obtained from the University of Campinas in 1986, PhD from Uppsala University, Sweden in 1993. Pos-doc fellow at Campinas University and Harvard University. Currently Full Professor of Medicine, University of Campinas. Former member of the Editorial Board of Clinical Endocrinology. Current member of the Editorial Board International Journal of Obesity. Research field, obesity and diabetes. (Source: Lattes Curriculum)
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Obesity affects over 600 million people worldwide and, despite recent therapeutic advance in the field, projections estimate a continuous increase of its prevalence over the next decade. In this context, the identification of new targets could improve therapeutic strategies and contribute to revert the current epidemiological scenario. G protein-coupled receptors (GPCRs) are the targets f…
Obesity is a global epidemic due to a homeostatic imbalance between caloric intake and expenditure. Currently, there are no totally effective and safe drugs for reversing and maintaining this condition. Understanding the central mechanisms involved in energy homeostasis is important for a better comprehension of obesity, as well as for developing better therapeutic strategies. The POMC su…
The need to measure and evaluate different biological processes non-invasively in living models led researchers from different countries to develop more than 1,600 different radiopharmaceuticals to evaluate various metabolic processes, protein synthesis, expression of different receptors, genes and antibodies, enzyme and hormone activity, DNA replication, and for therapy. Until recently, …
(Only some records are available in English at this moment)
The pandemic of the new severe acute respiratory syndrome virus (SARS-CoV-2) has already been confirmed in more than 330 thousand people, being responsible for more than 14 thousand deaths worldwide (World Health Organization - official data of 23 March 2020). The current treatment for severe cases is based on respiratory support, use of a variety of antibiotics with possible extracorpore…
The main objectives of the project are to elucidate the effect of activation of the long-chain fatty acid receptors FFA4 and FFA1 in the hypothalamus on appetite and obesity; determine the ability of fatty acids in various forms, including as free fatty acids, triacylglycerides, and phospholipids, to reach the central CNS after oral intake and investigate the ability of dietary fatty acid…
Mais de 500 proteínas quinases estão presentes no genoma humano, atuando como chaves regulatórias de praticamente todos os processos fisiológicos do organismo humano. As quinases podem ser moduladas através de pequenas moléculas químicas altamente potentes. No entanto, apesar de sua importância e adequação para a descoberta de fármacos, a maioria das pesquisas acadêmicas e farmacêuticas t…
(Only some records are available in English at this moment)
Obesity is one of the most prevalent diseases on the planet, affecting more than 600 million people, and increasing the risk of developing several comorbidities, such as diabetes mellitus, high blood pressure, dyslipidemia, and cardiovascular diseases. Obesity results from a chronic process of positive energy balance, in which caloric intake overlaps energy expenditure. Hypothalamic neuro…
Obesity is currently one of the most prevalent diseases on the planet. Unfortunately, behavioral approaches, which include increasing physical activity combined with reducing caloric intake, have a high rate of refractoriness, and in general, patients are unable to adhere to the recommendations for long periods. In the last decade, the introduction of glucagon-like peptide-1 receptor agon…
Obesity is defined as the abnormal or excessive accumulation of fat that is epidemiologically associated with a number of other medical conditions that offer health risks as well as economic losses to the individual and to society. It is one of the most prevalent diseases on the planet. It results from an imbalance between energy expenditure and food intake, being, from the intuitive poin…
(Only some records are available in English at this moment)
Neurons in the mediobasal hypothalamus are responsible for coordinating responses to systemic stimuli that indicate the body's energy reserves. In addition to responding to hormones such as leptin and insulin, these neurons are also responsive to nutrients. A nutrient widely consumed in Western-style diets is fructose, used in various preparations such as soft drinks, juices and some soli…
Hidradenitis suppurativa (HS) is a severe inflammatory skin disease characterized by recurrent chronic lesions, nodules, fistulas and abscesses, which often manifests on the scalp, neck, armpits, perineum and inframammary areas. Photobiomodulation (FBM) employs the ionizing energy from light and is used to reduce pain, inflammation, swelling and regenerate tissuedamaged, such as wounds, b…
(Only some records are available in English at this moment)
Obesity affects over 600 million people worldwide and, despite recent therapeutic advance in the field, projections estimate a continuous increase of its prevalence over the next decade. In this context, the identification of new targets could improve therapeutic strategies and contribute to revert the current epidemiological scenario. G protein-coupled receptors (GPCRs) are the targets f…
Background: Lipodystrophy, similar to obesity, is a disease with white adipose tissue dysfunction, but with worse metabolic profile. The inherited lipodystrophies can be classified as generalized or partial, with the extent of adipose tissue loss being associated with the severity of the metabolic complications. Brown adipose tissue has different embryonic origin from WAT and the presence…
The hypothalamus is a key region in the central nervous system that controls different functions such as energy balance, thermogenesis, and reproduction, which are essential to species' adaptation and survival. Adult neurogenesis in the hypothalamus has been known to renew subpopulations of neurons that play central roles in controlling energy homeostasis. Additionally, preliminary studie…
Obesity is one of the main health problems in Brazil and worldwide and the recent advances in the comprehension of its physiopathology has indicated the existence of a functional impairment of the hypothalamic-associated control over food intake. The hypothalamus integrates peripheral signals to complex neurocircuits and exerts a preponderant control over food intake and metabolism throug…
(Only some records are available in English at this moment)
| 4 / 4 | Ongoing research grants |
| 11 / 7 | Completed research grants |
| 26 / 26 | Ongoing scholarships in Brazil |
| 104 / 65 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 13 / 12 | Completed scholarships abroad |
| 159 / 115 | All research grants and scholarships |
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CV Lattes
ORCID