CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Faculdade de Ciências Aplicadas (FCA) (Institutional affiliation from the last research proposal) Birthplace: Brazil
1993 1997 B.S. in Nutrition, Federal University of Mato Grosso, UFMT, Brazil; 1997 1998 Specialization in Public Health, University of Ribeirão Preto, UNAERP, Brazil; 2003 2005 M.S. in Health Sciences, Federal University of Mato Grosso, UFMT, Brazil; 2007 2008 Ph.D. in Biochemistry, University of Barcelona, Spain; 2005 2009 Ph.D. in Medical Clinic University of Campinas, UNICAMP, Brazil; 2009 2011 Postdoctoral Training in Medical Clinic University of Campinas, UNICAMP, Brazil; 2016 - 2017 Visiting Professor Cell Biology Program SickKids Research Institute/Toronto-CA; 2017 2017 Visiting Professor - Université PARIS- DIDEROT 7/FrançaMAIN INTEREST IN RESEARCH - Role of lipid excess (saturated fat acids and interesterified lipids) in the development of obesity and type 2 diabetes. Metabolic and molecular aspects. Significant scientific contributions: - Characterization of the role of high-fat diets in body energy homeostasis and the mechanisms involved in hypothalamic resistance to leptin and insulin. - Identification of TLR4 activation and subsequent induction of endoplasmic reticulum stress as mechanisms involved in hypothalamic resistance to leptin and insulin. Central inhibition of inflammation in DIO animals, by blocking the activation of TLR4 or ER stress was able to reverse the glucose homeostasis in part by inhibition of hepatic glucose production. - Role of hypothalamic autophagy in the regulation of glucose homeostasis induced by obesity - Characterization of the role of interesterified fat in metabolism. Interesterified soybean oil promotes weight, impaired glucose tolerance and increase liver cellular stress markers in Swiss mice. (Source: Lattes Curriculum)
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Diets rich in fats have been the frequent target of studies and demonstrated a negative influence on energy metabolism, on the development of obesity and associated chronic diseases. In recent years, partially hydrogenated fat containing trans isomers has been linked to deleterious effects on health, such as dyslipidemia, cardiovascular disease and obesity. However, with the prohibition o…
Obesity represents a serious public health problem and, because it's a chronic multifactorial disease, predisposes the body to a series of diseases, and it is related to increased mortality rate. Also considered a condition where there is activation of low-grade systemic inflammation, obesity is directly related to increased levels of proinflammatory markers, changes in intestinal permeab…
Obesity is a disease characterized by the excess of adipose tissue, which compromises health and have become a health global issue in the last decades. Changes in the dietary pattern, associated with the intake of foods with elevated energy density, containing significant amounts of saturated, trans and interesterified fat, associated with a decrease in physical activity levels are major …
Recently, interesterified fat has been used as an alternative to trans fats. Interesterification is a process performed through chemical or enzymatic methods, which rearranges the fatty acids on the glycerol molecule without changing their saturation level. Previous data have shown that consuming interesterified fat affects glycemic homeostasis, promotes activation of inflammatory pathway…
Interesterified fat has been an alternative for the food industry to the use of trans fat. The interesterification process promotes the reorganization of fatty acids in the glycerol molecule, without changing their degree of saturation. Recent studies have shown that its long-term consumption is related to the development of metabolic disorders in rodents, such as the promotion of weight …
Lipids are essential for the human body, participating in important functions such as energy storage, cell signaling, formation of steroid hormones, cell structures and other functions essential to life. However, fats have been excessively used in the contemporary diet, especially in processed and ultra-processed industrialized products, whose consumption is associated with metabolic diso…
Recently, interesterified fat has been used as an alternative to the use of trans fats. The interesterified fat is obtained by processing vegetable oils using chemical or enzymatic methods, which results in rearranging in the fatty acids of the glycerol molecule, without changing the degree of saturation thereof. Recent studies have shown adverse metabolic effects in response to chronic f…
(Only some records are available in English at this moment)
The food industry used to benefit from the process known as partial hydrogenation of vegetable oils and fats to produce trans fatty acids, thus giving processed and ultra-processed food desirable characteristics such as: oxidative stability, lower cost and higher sensorial value. Conversely, the use of trans-fat was widely related to cardiovascular disease and mortality worldwide, leading…
The consumption of fatty acids seems to be an important factor for the development and progression of obesity. Recently, studies have shown that a crucial process for maintaining the functionality of hypothalamic neurons and subsequent control of body energy balance known as autophagy appears to be involved in the pathogenesis of obesity. Autophagy is a catabolic process, which aims to ma…
During the last decades, studies of different dietary fatty acids have been carried out to understand the effect of fat intake on risk markers for obesity and associated disease. The overconsumption of dietary fats leads to diet-induced activation of inflammatory pathways which is implicated in driving aspects of metabolic dysfunction, including the development of obesity and insulin resi…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 3 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 11 / 10 | Completed scholarships in Brazil |
| 6 / 6 | Completed scholarships abroad |
| 23 / 21 | All research grants and scholarships |
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