Evaluation of Sodium Diclofenac Release Using Natural Rubber Latex as Carrier

Author(s)

Aielo, Patricia B. ^[1] ; Borges, Felipe A. ^[1] ; Romeira, Karoline M. ^[1] ; Romeiro Miranda, Matheus Carlos ^[2] ; de Arruda, Larisa B. ^[3] ; Filho, Paulo Noronha L. ^[3] ; Drago, Bruno de C. ^[3] ; Herculano, Rondinelli D. ^[1]

Affiliation

^[1] Univ Estadual Paulista UNESP, Fac Ciencias & Letras Assis, Dept Ciencias Biol, Assis, SP - Brazil

^[2] Univ Estadual Paulista UNESP, Inst Quim, BR-14800060 Araraquara, SP - Brazil

^[3] Univ Estadual Paulista UNESP, Fac Ciencias, Dept Fis, Bauru, SP - Brazil

• Document type: Journal article
• Source: MATERIALS RESEARCH-IBERO-AMERICAN JOURNAL OF MATERIALS; v. 17, n. 1, p. 146-152, AUG 2014.
• Web of Science Citations: 23

Abstract

Sodium Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) taken to reduce inflammation and, as an analgesic, reduce pain. Although this drug is widely used in the general population, properties such as the short half-time and some side effects restrict its clinical use. The most common side effects are: gastric irritation, gastritis, peptic ulcer and bleeding. Studies involving biomaterials as carrier for drug release have been proving their efficiency in overcoming those problems and better controling the release rate and targeting of the drug. Natural rubber latex (NRL) has been proven excellent for its biocompatibility and ability to stimulate angiogenesis, cellular adhesion and the formation of extracellular matrix, promoting the replacement and regeneration of tissue. In this work, a NRL membrane is used to deliver sodium diclofenac. Sodium diclofenac (NaDic) was found to be adsorbed on the NRL membrane, with little or no incorporation into the membrane bulk, according to energy dispersive Scanning Electron Microscopy with X-Ray microanalysis (SEM-EDS) spectroscopy. In addition, FT-IR shows that there is no molecular-level interaction between drug and NRL. Already, the X-Ray Diffraction (XRD) of NaDic-NRL shows a broader one spectrum than the sharper halo (amorphous characteristic XRD spectrum) of pure NRL. More importantly, the release time of diclofenac in a NRL membrane in vitro was increased from the typical 2-3 h for oral tablets to ca. 74 h. The kinetics of the drug release could be fitted with a double exponential function, with two characteristic times of 0.899 and 32.102 h. In this study, we demonstrated that the interesting properties provided by NRL membranes combined with a controlled release of drug is relevant for biomedical applications. (AU)

• FAPESP's process: 11/17411-8 - Evaluation of drugs delivery systems using natural rubber latex membranes as carrier
• Grantee: Rondinelli Donizetti Herculano
• Support Opportunities: Regular Research Grants