Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antifungal Compounds Produced by Colletotrichum gloeosporioides, an Endophytic Fungus from Michelia champaca

Full text
Author(s):
Chapla, Vanessa Mara [1] ; Zeraik, Maria Luiza [1] ; Leptokarydis, Ioanis Hcristos [1] ; Silva, Geraldo Humberto [2] ; Bolzani, Vanderlan Silva [1] ; Young, Maria Claudia M. [3] ; Pfenning, Ludwig Heinrich [4] ; Araujo, Angela Regina [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista, NuBBE Nucleo Bioensaios Biossintese & Ecofisiol P, Dept Quim Organ, Inst Quim, UNESP, BR-14800900 Araraquara, SP - Brazil
[2] Univ Fed Vicosa, Inst Ciencias Exatas, BR-38810000 Vicosa, MG - Brazil
[3] Nucleo Pesquisa Fisiol & Bioquim, Inst Bot, BR-04301902 Sao Paulo - Brazil
[4] Univ Fed Lavras, Dept Fitopatol, BR-37200000 Lavras, MG - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Molecules; v. 19, n. 11, p. 19243-19252, NOV 2014.
Web of Science Citations: 19
Abstract

In this study, eight endophytic fungi were isolated from the leaves, stems and roots of Michelia champaca. The isolates were screened and evaluated for their antifungal, anticancer and acetylcholinesterase (AChE) inhibitory activities. All of the extracts exhibited potent activity against two evaluated phytopathogenic fungi. Chemical investigation of EtOAc extracts of the endophytic fungus Colletotrichum gloeosporioides resulted in the isolation of one new compound, 2-phenylethyl 1H-indol-3-yl-acetate (1), and seven known compounds: uracil (2), cyclo-(S{*}-Pro-S{*}-Tyr) (3), cyclo-(S{*}-Pro-S{*}-Val) (4), 2(2-aminophenyl)acetic acid (5), 2(4-hydroxyphenyl) acetic acid (6), 4-hydroxy-benzamide (7) and 2(2-hydroxyphenyl) acetic acid (8). All of the compound structures were elucidated using 1D and 2D NMR and MS analyses. The antifungal and AChE inhibitory activities of compounds 1-8 were evaluated in vitro. Compound 1 exhibited promising activity against Cladosporium cladosporioides and C. sphaerospermum that was comparable to that of the positive control nystatin. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants
FAPESP's process: 13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery
Grantee:Glaucius Oliva
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/03017-6 - Natural products from plants of Cerrado and Atlantic Forest, potential models and useful for identifying prototypes with oxidizing action on neutrophils and myeloperoxidase (MPO) enzyme
Grantee:Maria Luiza Zeraik
Support Opportunities: Scholarships in Brazil - Post-Doctoral