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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structural Characterization of New Peptide Variants Produced by Cyanobacteria from the Brazilian Atlantic Coastal Forest Using Liquid Chromatography Coupled to Quadrupole Time-of-Flight Tandem Mass Spectrometry

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Author(s):
Sanz, Miriam [1] ; Dini Andreote, Ana Paula [2] ; Fiore, Marli Fatima [2] ; Doerr, Felipe Augusto [1] ; Pinto, Ernani [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Pharmaceut Sci, BL-17055089 Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Ctr Nucl Energy Agr, BR-13400970 Piracicaba, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: MARINE DRUGS; v. 13, n. 6, p. 3892-3919, JUN 2015.
Web of Science Citations: 9
Abstract

Cyanobacteria from underexplored and extreme habitats are attracting increasing attention in the search for new bioactive substances. However, cyanobacterial communities from tropical and subtropical regions are still largely unknown, especially with respect to metabolite production. Among the structurally diverse secondary metabolites produced by these organisms, peptides are by far the most frequently described structures. In this work, liquid chromatography/electrospray ionization coupled to high resolution quadrupole time-of-flight tandem mass spectrometry with positive ion detection was applied to study the peptide profile of a group of cyanobacteria isolated from the Southeastern Brazilian coastal forest. A total of 38 peptides belonging to three different families (anabaenopeptins, aeruginosins, and cyanopeptolins) were detected in the extracts. Of the 38 peptides, 37 were detected here for the first time. New structural features were proposed based on mass accuracy data and isotopic patterns derived from full scan and MS/MS spectra. Interestingly, of the 40 surveyed strains only nine were confirmed to be peptide producers; all of these strains belonged to the order Nostocales (three Nostoc sp., two Desmonostoc sp. and four Brasilonema sp.). (AU)

FAPESP's process: 12/25272-0 - ISOLATION AND ESTRUCTURAL CHARACTERTHERIZATION OF NOVEL COMPOUNDS WITH POTENCIAL THERAPEUTIC APPLICATION FROM BRAZILIAN FRESHWATER CYANOBACTERIA
Grantee:Miriam Sanz Roldán
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 09/15402-1 - Cyanobacteria of the Atlantic Forest phyllosphere: isolation, taxonomy and bioprospecting
Grantee:Ana Paula Dini Andreote
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/09192-0 - Saline lakes in the Pantanal of Nhecolândia: Hydro-bio-geochemistry of a singular wetland
Grantee:Laurent Barbiero
Support Opportunities: Regular Research Grants
FAPESP's process: 11/51950-3 - Prospecting volatile compounds produced by Brazilian cyanobacteria with allelopathic effects
Grantee:Ernani Pinto Junior
Support Opportunities: Research Grants - Research Partnership for Technological Innovation - PITE