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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effectiveness of a Toothpaste with Low Fluoride Content Combined with Trimetaphosphate on Dental Biofilm and Enamel Demineralization in situ

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Author(s):
Takeshita, Eliana M. [1] ; Danelon, Marcelle [1] ; Castro, Luciene P. [1] ; Sassaki, Kikue T. [1] ; Delbem, Alberto C. B. [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Paulista, UNESP, Aracatuba Dent Sch, BR-16015050 Aracatuba, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Caries Research; v. 49, n. 4, p. 394-400, 2015.
Web of Science Citations: 12
Abstract

Objective: The aim of the present study was to evaluate in situ whether a toothpaste with low fluoride associated with sodium trimetaphosphate (TMP) would provide similar effect to that of a 1,100 ppm F toothpaste. Design: This crossover double-blind study consisted of 4 phases (14 days each), during which 10 volunteers wore oral appliances containing 4 enamel bovine blocks. The cariogenic challenge was performed by the application of a 20% sucrose solution (6x/day). The toothpaste treatments (2x/day) were: placebo, 500 ppm F, 500 ppm F plus 1% TMP, and 1,100 ppm F. At the end, enamel mineral loss and biofilm composition were analyzed. Results: The toothpaste with 500 ppm F plus 1% TMP showed the lowest mineral loss (p < 0.05). Regarding the fluoride and calcium concentrations in the enamel and in the biofilm, there were no significant differences between 500 ppm F plus 1% TMP, and 1,100 ppm F toothpastes (p > 0.569), but they were significantly different when compared to toothpaste with 500 ppm F (p < 0.050). Conclusion: The addition of 1% TMP to a low-fluoride toothpaste reduces enamel demineralization in situ similar to a 1,100 ppm F toothpaste. (C) 2015 S. Karger AG, Basel (AU)

FAPESP's process: 07/03660-0 - In situ demineralization of enamel in response to a dentifrice with low fluoride content supplemented with phosphate
Grantee:Alberto Carlos Botazzo Delbem
Support Opportunities: Regular Research Grants
FAPESP's process: 07/03254-2 - In situ evaluation of anticariogenic action of dentifrice with low fluoride content and supplemented with phosphate
Grantee:Eliana Mitsue Takeshita
Support Opportunities: Scholarships in Brazil - Doctorate