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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evolution in miniaturized column liquid chromatography instrumentation and applications: An overview

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Nazario, Carlos E. D. [1] ; Silva, Meire R. [2] ; Franco, Maraissa S. [2] ; Lancas, Fernando M. [2]
Total Authors: 4
[1] Univ Fed Goias, Dept Chem, Jatai, Go - Brazil
[2] Univ Sao Paulo, Inst Chem Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: Journal of Chromatography A; v. 1421, p. 18-37, NOV 20 2015.
Web of Science Citations: 39

The purpose of this article is to underline the miniaturized LC instrumental system and describe the evolution of commercially available systems by discussing their advantages and drawbacks. Nowadays, there are already many miniaturized LC systems available with a great variety of pump design, interface and detectors as well as efficient columns technologies and reduced connections devices. The solvent delivery systems are able to drive the mobile phase without flow splitters and promote gradient elution using either dual piston reciprocating or syringe-type pumps. The mass spectrometry as detection system is the most widely used detection system; among many alternative ionization sources direct-EI LC-MS is a promising alternative to APCI. In addition, capillary columns are now available showing many possibilities Of stationary phases, inner diameters and hardware materials. This review provides a discussion about miniaturized LC demonstrating fundamentals and instrumentals' aspects of the commercially available miniaturized LC instrumental system mainly nano and micro LC formats. This review also covers the recent developments and trends in instrumentation, capillary and nano columns, and several applications of this very important and promising field. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 05/59360-0 - Miniaturization of analytical instrumentation for separation techniques: sample preparation and printing of result
Grantee:Fernando Mauro Lanças
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/07347-9 - Development of novel materials and devices for miniaturized sample preparation techniques in the area of food safety
Grantee:Fernando Mauro Lanças
Support type: Regular Research Grants
FAPESP's process: 12/22055-9 - Development of silica modified with ionic liquids and their use in sample preparation techniques
Grantee:Meire Ribeiro da Silva
Support type: Scholarships in Brazil - Doctorate