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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of ACTN3 R577X polymorphism on ventilatory thresholds related to endurance performance

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Pasqua, Leonardo A. [1] ; Bueno, Salomao [1] ; Artioli, Guilherme G. [2] ; Lancha, Antonio H. [2] ; Matsuda, Monique [3] ; Marquezini, Monica V. [4] ; Lima-Silva, Adriano E. [5] ; Saldiva, Paulo H. N. [4] ; Bertuzzi, Romulo [1, 4]
Total Authors: 9
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Endurance Performance Res Grp, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Dept Pathol, Lab Expt Air Pollut, Fac Med, Sao Paulo, SP - Brazil
[5] Univ Fed Pernambuco, Dept Phys Educ & Sports Sci CAV, Sport Sci Res Grp, Vitoria De Santo Antao, PE - Brazil
Total Affiliations: 5
Document type: Journal article
Source: JOURNAL OF SPORTS SCIENCES; v. 34, n. 2, p. 163-170, JAN 17 2016.
Web of Science Citations: 6

The purpose of this study was to verify the association between ACTN3 polymorphism and physiological parameters related to endurance performance. A total of 150 healthy male volunteers performed a maximal incremental running test to determine the speeds corresponding to ventilatory threshold (VT) and respiratory compensation point (RCP). Participants were genotyped and divided into terciles based on the analysed variables. Genotype frequencies were compared through (2) test between lower and higher terciles, with the lowest or highest values of each analysed variable. ACTN3 XX genotype was over-represented in higher tercile for VT and RCP. Odds ratio also showed significantly higher chances of XX individuals to be in higher tercile compared to RR (7.3) and RR + RX (3.5) for VT and compared to RR genotype (8.1) and RR + RX (3.4) for RCP. Thus, XX individuals could attain the VT and RCP at higher speeds, suggesting that they are able to sustain higher running speeds in lower exercise intensity domains. It could result in higher lipid acids oxidation, saving muscle glycogen and delaying the fatigue during prolonged exercises, which could be the advantage mechanism of this genotype to endurance performance. (AU)

FAPESP's process: 12/07319-0 - Effect of an alimentary supplement used in order to improve bone mineral density
Grantee:Antonio Herbert Lancha Junior
Support type: Scholarships abroad - Research
FAPESP's process: 10/13913-6 - Running economy and muscle strength: a relationship with ACTN3 gene R577X polymorphism
Grantee:Leonardo Alves Pasqua
Support type: Scholarships in Brazil - Master
FAPESP's process: 11/17059-2 - Effects of beta-alanine supplementation combined or not with sodium bicarbonate on intermittent anaerobic performance
Grantee:Guilherme Giannini Artioli
Support type: Scholarships in Brazil - Post-Doctorate