Fast preparation of free-standing nanohydroxyapatite-vertically aligned carbon nanotube scaffolds

Author(s)

Grinet, Marco A. V. M. ^[1] ; Zanin, Hudson ^[2] ; Campos Granata, Alessandro Eustaquio ^[3] ; Porcionatto, Marimelia ^[3] ; Marciano, Fernanda Roberta ^[1] ; Lobo, Anderson Oliveira ^[1]

Affiliation

^[1] Univ Vale Paraiba, Lab Biomed Nanotechnol, Inst Res & Dev, BR-12224000 Sao Paulo - Brazil

^[2] Inst Nacl Pesquisas Espaciais, Lab Associado Sensores & Mat, BR-12227010 Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Neurobiol Lab, BR-04039032 Sao Paulo - Brazil

• Document type: Journal article
• Source: JOURNAL OF MATERIALS CHEMISTRY B; v. 2, n. 9, p. 1196-1204, MAR 7 2014.
• Web of Science Citations: 18

Abstract

We present a simple, low cost, and fast method to produce free-standing nanohydroxyapatite/carbon-based scaffolds. We electrodeposited nanohydroxyapatite onto vertically aligned carbon nanotube flakes and reticulated vitreous carbon bars. We prepared a highly crystalline and homogeneous thin film without any post-thermal treatment, and our results evidence that we can control the nanohydroxyapatite crystal formation according to the substrate employed. Immersion tests using simulated body fluid showed that these new nanobiomaterials had in vitro bioactivity. The free-standing nanohydroxyapatite/carbon-based scaffolds have been shown to be a suitable surface for mesenchymal stem cell adhesion with active formation of membrane projections and cell monolayer formation. (AU)

• FAPESP's process: 11/20345-7 - Study of nanoparticle-incorporated diamond-like carbon films for biomedical applications
• Grantee: Fernanda Roberta Marciano
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 13/07696-0 - Production of polymeric scaffolds by rotary-jet-spinning technique with incorporated carbon nanotubes
• Grantee: Marco Antonio Vieira Macedo Grinet
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 11/17877-7 - Development of new polymeric scaffolds by electrospinning technique with incorporation of vertically aligned carbon nanotubes and nanohidroxyapatite for bone tissue regeneration
• Grantee: Anderson de Oliveira Lobo
• Support Opportunities: Research Grants - Young Investigators Grants