Synthesis, spectroscopic characterization, crystallographic studies and antibacterial assays of new copper(II) complexes with sulfathiazole and nimesulide

Author(s)

Bormio Nunes, Julia Helena ^[1] ; Ferraz de Paiva, Raphael Enoque ^[1] ; Cuin, Alexandre ^[2] ; da Costa Ferreira, Ana Maria ^[3] ; Lustri, Wilton Rogerio ^[4] ; Corbi, Pedro Paulo ^[1]

Affiliation

^[1] Univ Campinas UNICAMP, Bioinorgan & Med Chem Res Lab, Campinas, SP - Brazil

^[2] Fed Univ Juiz de Fora UFJF, Bioinorgan Chem Res Lab, Juiz De Fora, MG - Brazil

^[3] Univ Sao Paulo, Bioinorgan Catalysis & Pharmacol Lab, Sao Paulo, SP - Brazil

^[4] Univ Ctr Araraquara UNIARA, Biol & Hlth Sci Dept, Araraquara, SP - Brazil

• Document type: Journal article
• Source: Journal of Molecular Structure; v. 1112, p. 14-20, MAY 15 2016.
• Web of Science Citations: 13

Abstract

New ternary copper(II) complexes of sulfathiazole (SFT, C9H8N3O2S2) or nimesulide (NMS, C13H11N2O5S) and 2,2'-bipyridine (bipy) were synthesized, and characterized by chemical and spectroscopic techniques. Elemental analyses indicated a 2:1:1 sulfonamide/copper/bipy composition for both complexes. Mass spectrometric measurements permitted identifying the molecular ions {[}Cu(SFT)(2)(bipy)+H](+) and {[}Cu(NMS)(2)(bipy)+H](+) at m/z 728 and 835, respectively, confirming the proposed compositions. Crystal structure of the {[}Cu(SFT)(2)(bipy)] complex was solved by powder X-ray diffraction analysis (PXRD), attesting that the Cu(II) ion is hexacoordinated in a distorted octahedral geometry. Each SFr molecule coordinates to the metal ion by the nitrogen atoms of the SO2-N group and of the heterocyclic ring. The coordination sphere is completed by a bipyridine. Electronic paramagnetic resonance (EPR) studies were carried out for the {[}Cu(NMS)(2)(bipy)] complex, indicating a tetragonal environment around the metal ion. It was suggested that NMS coordinates to Cu(II) by the nitrogen and oxygen atoms of the SO2-N group, which was confirmed by infrared spectroscopic studies. Biological studies showed the antibacterial activity of both Cu-SFT and Cu-NMS complexes, with the minimum inhibitory concentration (MIC) values ranging from 0.10 to 0.84 mmol L-1 against Gram-negative bacteria for {[}Cu(SFT)(2)(bipy)], and from 1.50 to 3.00 mmol L-1 against Gram-positive and -negative bacteria for {[}Cu(NMS)(2)(bipy)]. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants