Continuous infusion of propofol in calves: bispectral index and hemodynamic effects

Author(s)

Deschk, Mauricio ^[1] ; Wagatsuma, Juliana T. ^[1] ; Araujo, Marcelo A. ^[1] ; Santos, Guilherme G. F. ^[1] ; Junior, Sergio S. R. ^[1] ; Abimussi, Caio J. X. ^[1] ; Siqueira, Carlos E. ^[1] ; Motta, Jessica C. L. ^[1] ; Perri, Silvia H. V. ^[2] ; Santos, Paulo S. P. ^[1]

Affiliation

^[1] Sao Paulo State Univ, UNESP, Fac Vet Med, Dept Clin Surg & Anim Reprod, BR-16050680 Aracatuba, SP - Brazil

^[2] Sao Paulo State Univ, UNESP, Fac Vet Med, Dept Support Anim Prod & Hlth DAPSA, BR-16050680 Aracatuba, SP - Brazil

• Document type: Journal article
• Source: VETERINARY ANAESTHESIA AND ANALGESIA; v. 43, n. 3, p. 309-315, MAY 2016.
• Web of Science Citations: 3

Abstract

ObjectiveTo assess the bispectral index (BIS) and the hemodynamic effects of propofol administered by continuous infusion at different rates in calves. Study designExperimental crossover study. AnimalsEight intact male Dutch calves, aged 6-12months and weighing 84-124kg. MethodsThe calves were anesthetized with propofol (5mgkg(-1)) intravenously (IV), and after endotracheal intubation, positioned in right lateral recumbency and allowed to breathe ambient air. Anesthesia was maintained by continuous infusion of propofol, administered IV with an infusion pump at 0.6mgkg(-1)minute(-1) (treatment G6) or 0.8 mgkg(-1)minute(-1) IV (treatment G8), for 60minutes. The eight animals were anesthetized twice, 1week apart. The following hemodynamic variables and BIS were assessed before the induction of anesthesia (baseline) and 15, 30, 45, and 60minutes after beginning the infusion of propofol: heart rate, systolic, diastolic and mean arterial pressures, cardiac output, mean pulmonary artery pressure, cardiac index, stroke index, pulmonary vascular resistance index, and systemic vascular resistance index, BIS, electromyography, and signal quality index. ResultsThe continuous infusions of propofol at different rates did not alter BIS variables during the infusion time between dose rates, and no clinically significant hemodynamic changes were observed. Conclusions and clinical relevanceA continuous infusion of propofol at 0.6 or 0.8mgkg(-1)minute(-1) caused minimal hemodynamic changes without clinical relevance in calves. BIS could not be reliably used to discriminate the anesthetic depth during the two propofol infusion rates. (AU)

• FAPESP's process: 10/11948-7 - BISPECTRAL INDEX, HEMODYNAMIC AND RESPIRATORY EFFECTS OF CONTINUOUS RATE INFUSION OF PROPOFOL IN CALVES.
• Grantee: Mauricio Deschk
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 10/19568-9 - Bispectral index, hemodinamic and respiratory effects of continuous infusion in differents rates of propofol in calves breathing spontaneously
• Grantee: Paulo Sergio Patto dos Santos
• Support Opportunities: Regular Research Grants