Carbon-nanotube amperometric sensor for selective determination of 4-chloroaniline in commercial chlorhexidine solutions

Author(s)

Montes, Rodrigo H. O. ^[1] ; Lima, Ana P. ^[1] ; dos Santos, Vagner B. ^[2] ; Vidal, Denis T. R. ^[2] ; do Lago, Claudimir L. ^[2] ; Richter, Eduardo M. ^[1] ; Munoz, Rodrigo A. A. ^[1]

Affiliation

^[1] Univ Fed Uberlandia, Inst Quim, Av Joao Naves Avila 2121, BR-38408100 Uberlandia, MG - Brazil

^[2] Univ Sao Paulo, Inst Quim, Av Prof Lineu Prestes 748, BR-05508500 Sao Paulo, SP - Brazil

• Document type: Journal article
• Source: SENSORS AND ACTUATORS B-CHEMICAL; v. 231, p. 38-44, AUG 2016.
• Web of Science Citations: 5

Abstract

This work reports a carbon-nanotube amperometric sensor for the selective determination of 4-chloroaniline (4-CLA), the major degradation product found in commercial chlorhexidine solutions. The harmful 4-CLA is detected on a multi-walled carbon nanotube (MWCNT)-modified electrode, free from the interference of chlorhexidine and other substances present in such samples, with a detection limit of 50 nmol L-1. MWCNTs of two different dimensions were evaluated for 4-CLA detection and a 3-fold increase in sensitivity using both modified electrodes was obtained in comparison with the bare electrode. The association of batch-injection analysis with the amperometric detection provided high precision (1.2%) and sample throughput (130 h(-1)). Analyses of samples by capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) attested the accuracy of the proposed method. Mouth rinse and skin disinfectant samples presented 4-CLA concentrations in the range between 4 and 235 mu mol L-1. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 11/02156-2 - The use of capillary electrophoresis with contactless conductivity detection for obtaining analytical and physicochemical parameters of peroxycarbonate, peroxyacids, and monoethyl pyrocarbonate.
• Grantee: Denis Tadeu Rajh Vidal
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/14993-1 - Characterization and quantification of monoalkyl carbonates in aqueous medium employing microfluidic devices coupled to a mass spectrometer
• Grantee: Vagner Bezerra dos Santos
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 12/06642-1 - Formation and properties of adducts of organic hydroxy-compounds with carbonate in aqueous medium and biological conditions
• Grantee: Claudimir Lucio Do Lago
• Support Opportunities: Regular Research Grants