Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

Author(s)

William Marciel de Souza ; Alex Martins Machado ; Luiz Tadeu Moraes Figueiredo

• Document type: Journal article
• Source: Memórias do Instituto Oswaldo Cruz; v. 111, n. 6, p. 399-402, Jun. 2016.
• Web of Science Citations: 1

Abstract

This study shows an experimental spillover infection of Sigmodontinae rodents with Rio Mamore hantavirus (RIOMV). Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals. (AU)

• FAPESP's process: 11/05067-0 - Study of the mechanisms of infection and transmission of hantaviruses in rodent reservoir Araraquara (Necromys lasiurus)
• Grantee: William Marciel de Souza
• Support type: Scholarships in Brazil - Master
• FAPESP's process: 12/24150-9 - Research of virus in wild rodents, mosquitoes and ticks
• Grantee: William Marciel de Souza
• Support type: Scholarships in Brazil - Doctorate
• FAPESP's process: 09/17518-7 - Characterization of Araraquara hantavirus infection in natural reservoirs (Necromys lasiurus) and in rodent model of human disease (Mesocricetus auratus)
• Grantee: Alex Martins Machado
• Support type: Scholarships in Brazil - Post-Doctorate
• FAPESP's process: 08/50617-6 - Studies on emerging viruses including arbovirus, robovirus, respiratory viruses and congenital transmission, at the Centro de Pesquisa em Virologia da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo
• Grantee: Luiz Tadeu Moraes Figueiredo
• Support type: Research Projects - Thematic Grants