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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of a Dicalcium and Tetracalcium Phosphate-Based Desensitizer on In Vitro Dentin Permeability

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Author(s):
Zhou, Jianfeng [1] ; Chiba, Ayaka [2] ; Scheffel, Debora L. S. [3] ; Hebling, Josimeri [3] ; Agee, Kelli [4] ; Niu, Li-na [5, 6, 7] ; Tay, Franklin R. [4] ; Pashley, David H. [4]
Total Authors: 8
Affiliation:
[1] Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing - Peoples R China
[2] Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Cariol & Operat Dent, Tokyo - Japan
[3] Univ Estadual Paulista, UNESP, Araraquara Dent Sch, Dept Orthodont & Pediat Dent, Sao Paulo - Brazil
[4] Augusta Univ, Dent Coll Georgia, Augusta, GA - USA
[5] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, State Key Lab Mil Stomatol, Xian - Peoples R China
[6] Fourth Mil Med Univ, Sch Stomatol, Natl Clin Res Ctr Oral Dis, Xian - Peoples R China
[7] Fourth Mil Med Univ, Sch Stomatol, Dept Prosthodont, Shaanxi Key Lab Oral Dis, Xian - Peoples R China
Total Affiliations: 7
Document type: Journal article
Source: PLoS One; v. 11, n. 6 JUN 30 2016.
Web of Science Citations: 1
Abstract

The present study evaluated the effectiveness of a dicalcium and tetracalcium phosphate-based desensitizer in reducing dentin permeability in vitro. Dentin fluid flow was measured before and after treatment of dentin with patent dentinal tubules using 1 or 3 applications of the dicalcium and tetracalcium phosphate containing agent Teethmate (TM) (TM) and comparing the results with two sodium fluoride varnishes Vella (TM) (VLA) and Vanish (TM) (VAN), after storage in artificial saliva for 24 h, 48 h and 7 days. Significant differences were observed among the 4 methods employed for reducing dentin permeability (p < 0.001) and the 3 post-treatment times (p < 0.001). VLA and VAN never achieved 50% permeability reductions consistently in any of the 3 time periods. Only the calcium phosphate-based desensitizer applied for 3 times consistently reduced dentin permeability by 50% after 24 h. When applied once, the permeability reduction of TM increased progressively over the 3 time periods. After 7 days, only one and three applications of the calcium phosphate-based desensitizer consistently reduced dentin permeability by more than 50%. Permeability reductions corresponded well with scanning electron microscopy examination of dentinal tubule orifice occlusion in dentin specimens treated with the agents. Overall, the dicalcium and tetracalcium phosphate-based desensitizer is effective in reducing dentin permeability via a tubule occlusion mechanism. The ability of the agent to reduce dentin permeability renders it to be potentially useful as a clinical dentin desensitizing agent, which has to be confirmed in future clinical studies. By contrast, the two sodium fluoride varnishes are not effective in dentin permeability reduction and should be considered as topical fluoride delivering agents rather than tubular orifice-blocking agents. (AU)

FAPESP's process: 14/18160-7 - Hydrophobic monomers infiltration into demineralized dentin using HEMA wet-bonding. A proof of concept
Grantee:Josimeri Hebling Costa
Support Opportunities: Scholarships abroad - Research
FAPESP's process: 14/17232-4 - Hydrophobic monomers infiltration into demineralized dentin using HEMA wet-bonding: a proof of concept
Grantee:Débora Lopes Salles Scheffel
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor