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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of glyphosate on hepatic tissue evaluating melanomacrophages and erythrocytes responses in neotropical anuran Leptodactylus latinasus

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Author(s):
Manuel Perez-Iglesias, Juan [1, 2] ; Franco-Belussi, Lilian [3] ; Moreno, Liliana [1] ; Tripole, Susana [1] ; de Oliveira, Classius [3] ; Sebastian Natale, Guillermo [1, 2]
Total Authors: 6
Affiliation:
[1] Univ Nacl San Luis, PROICO 9401, Area Zool, Fac Quim Bioquim & Farm, Chacabuco 917, RA-5700 San Luis - Argentina
[2] Univ Nacl La Plata, Fac Ciencias Exactas, Ctr Invest Medio Ambiente, CONICET, Dept Quim, RA-1900 La Plata, Buenos Aires - Argentina
[3] Sao Paulo State Univ, Dept Biol, IBILCE, UNESP, Rua Cristovao Colombo 2265, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Environmental Science and Pollution Research; v. 23, n. 10, p. 9852-9861, MAY 2016.
Web of Science Citations: 15
Abstract

Glyphosate (GLY) is the most used herbicide worldwide and its effects on anurans are well known. Pollutants can cause physiological and morphological effects. Therefore, this study evaluated the effects of GLY on hepatic melanomacrophages as a response to environmental stressors. Three treatments were exposed to different concentrations of pure GLY (100, 1000, and 10,000 mu g g(-1), respectively), and there was also a control group. After the experimental time, liver and blood were analyzed. Melanomacrophages (MMCs) were located between the hepatocyte cordons, close to sinusoids. GLY increased the melanin area in MMCs of Leptodactylus latinasus exposed since lowest concentration until highest concentration. GLY also changed the occurrence of hepatic catabolism pigments into melanomacrophages and erythrocyte nuclear abnormalities; therefore, it can interfere with the hepatic metabolism. In conclusion, GLY promotes alterations in the hepatic tissue and erythrocyte nuclear abnormalities. Furthermore, MMCs may be useful as morphological responses of GLY effects. (AU)

FAPESP's process: 13/02067-5 - Toxic effects of the herbicides Atrazine and Roundup in Eupemphix nattereri (Leiuperidae) and Rhinella schneideri (Bufonidae): morphological changes under different concentrations and abiotic conditions (pH, temperature and photoperiod)
Grantee:Classius de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 14/00946-4 - Internal Pigmentation in Ectotherms: Innate immunity and UV defense
Grantee:Lilian Franco Belussi
Support Opportunities: Scholarships in Brazil - Post-Doctoral