| Full text | |
| Author(s): |
Bauermeister, Anelize
;
Aguiar, Fernando Armani
;
Mauriz Marques, Lucas Maciel
;
Malta, Jr., Jose Dos Santos
;
Barros, Fabio
;
Callejon, Daniel Roberto
;
Moraes de Oliveira, Anderson Rodrigo
;
Lopes, Norberto Peporine
Total Authors: 8
|
| Document type: | Journal article |
| Source: | Planta Medica; v. 82, n. 15, p. 1368-1373, OCT 2016. |
| Web of Science Citations: | 2 |
| Abstract | |
Dihydroergotamine is a semisynthetic natural product derived from ergotamine, an ergot alkaloid. It is used to treat migraines, a neurological disease characterized by recurrent moderate to severe headaches. In this work, the in vitro metabolism of dihydroergotamine was evaluated in a biomimetic phase I reaction, aiming to verify all possible formed metabolites. Dihydroergotamine was submitted to an in vitro metabolism assay using rat liver microsomes, and the metabolites were analyzed by HPLC-MS/MS. The biomimetic reactions were performed with Jacobsen catalyst for scaling up production of oxidized metabolites. Two hydroxylated metabolites were isolated and characterized by MS/MS and H-1 NMR analysis. (AU) | |
| FAPESP's process: | 13/16496-5 - In vitro, in vivo metabolism and pharmacokinetic profile evaluation of the alkaloid govaniadine |
| Grantee: | Lucas Maciel Mauriz Marques |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation |
| Grantee: | Norberto Peporine Lopes |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |