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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

beta-Carotene-loaded nanostructured lipid carriers produced by solvent displacement method

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Author(s):
Bernardes Oliveira, Davi Rocha ; Michelon, Mariano ; Furtado, Guilherme de Figueiredo ; Sinigaglia-Coimbra, Rita ; Cunha, Rosiane Lopes
Total Authors: 5
Document type: Journal article
Source: Food Research International; v. 90, p. 139-146, DEC 2016.
Web of Science Citations: 4
Abstract

Tristearin solid lipid nanoparticles and tristearin/high oleic sunflower oil nanostructured lipid carriers were produced by solvent displacement method. All conditions allowed forming polydisperse particles within nanometric range and the presence of high oleic sunflower oil did not affect the particles mean size. Nevertheless, incorporation of beta-carotene reduced the particles polydispersity. Thermograms of solid lipid nanoparticles and nano structured lipid carriers showed that sunflower oil generated a crystal order disturbance, since nanoparticles with less-organized lipid matrix were produced. Nanostructured lipid carriers exhibited an improvement of beta-carotene loading capacity when compared with solid lipid nanoparticles, which enhanced with the increasing of high oleic sunflower oil content. Although total beta-carotene degradation was similar for all systems, color analysis showed that the degradation of encapsulated beta-carotene was lower for high sunflower oil content. Nano structured lipid carriers exhibited advantages over the solid lipid nanoparticles, such as enhanced drug loading capacity and prevention of drug expulsion, which makes this a versatile delivery system for food applications. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 06/03263-9 - Process, packaging, edible coatings application and final quality evaluation of some high moisture tropical fruits
Grantee:Miriam Dupas Hubinger
Support Opportunities: Regular Research Grants
FAPESP's process: 09/54137-1 - Acquisition of a particle size/distribution analyzer, a zeta potential measurement system, a spray dryer, and an ultra-high-pressure liquid chromatograph/mass spectrometer
Grantee:Miriam Dupas Hubinger
Support Opportunities: Multi-user Equipment Program