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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Relationship between Maternal Plasma Leptin and Adiponectin Concentrations and Newborn Adiposity

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Author(s):
Castro, Natalia P. ; Euclydes, Veronica V. ; Simoes, Fernanda A. ; Vaz-de-Lima, Lourdes R. A. ; De Brito, Cyro A. ; Luzia, Liania A. ; Devakumar, Delan ; Rondo, Patricia H. C.
Total Authors: 8
Document type: Journal article
Source: NUTRIENTS; v. 9, n. 3 MAR 2017.
Web of Science Citations: 11
Abstract

Increased maternal blood concentrations of leptin and decreased adiponectin levels, which are common disturbances in obesity, may be involved in offspring adiposity by programming fetal adipose tissue development. The aim of this study was to assess the relationship between maternal leptin and adiponectin concentrations and newborn adiposity. This was a cross-sectional study involving 210 healthy mother-newborn pairs from a public maternity hospital in Sao Paulo, Brazil. Maternal blood samples were collected after delivery and leptin and adiponectin concentrations were measured by enzyme-linked immunosorbent assay. Newborn body composition was estimated by air displacement plethysmography. The association between maternal leptin and adiponectin concentrations and newborn adiposity (fat mass percentage, FM%) was evaluated by multiple linear regression, controlling for maternal age, socioeconomic status, parity, pre-pregnancy body mass index (BMI), weight gain, gestational age, and newborn age at the time of measurement. No relationship was found between maternal leptin and FM% of male or female newborn infants. Maternal adiponectin (p = 0.001) and pre-pregnancy BMI (p < 0.001; adj. R-2 = 0.19) were positively associated with FM% of newborn males, indicating that maternal adiponectin is involved in fetal fat deposition in a sex-specific manner. Large-scale epidemiological, longitudinal studies are necessary to confirm our results. (AU)

FAPESP's process: 11/05443-2 - The relationship between maternal and neonatal body composition
Grantee:Natália Pinheiro de Castro
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 11/10382-2 - Relationship between maternal body composition, serum leptin and adiponectin and body composition of their neonates
Grantee:Patricia Helen de Carvalho Rondó
Support Opportunities: Regular Research Grants